Chronic lymphocytic leukemia differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Differenting Chronic lymphocytic leukemia from other Diseases


Differential Diagnosis Surface Immunoglobulin CD5 CD22/FMC7 CD23 CD79b CD103

Chronic lymphocytic leukaemia

Weakly positive

Positive

Negative

Positive

Negative

Positive/Negative

Prolymphocytic leukaemia

Strongly positive

Negative

Positive

Negative

Positive

Negative

Hairy cell leukaemia

Strongly positive

Negative

Positive

Negative

Positive/Negative

Positive

Mantle cell lymphoma

Positive

Positive

Strongly positive

Negative

Strongly positive

Negative

Follicular lymphoma

Strongly positive

Negative

Positive

Negative

Strongly positive

Negative


  • Chronic lymphocytic leukemia must also be differentiated from other causes of fever, hepatosplenomegaly, and lymph node swelling such as:[2]

References

  1. 1.0 1.1 Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011
  2. Chronic Lymphocytic Leukimea. Wikipedia (2015) https://en.wikipedia.org/wiki/B-cell_chronic_lymphocytic_leukemia Accessed on October ,12 2015


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