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Revision as of 01:25, 15 October 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

According to the Rai Staging System, there are five stages of chronic lymphocytic leukemia based on the degree of lymphocytosis, hemoglobin level, platelets level, the presence of splenomegaly, and the presence of lymphadenopathy.[1] While according to the Binet Staging System, there are three stages of chronic lymphocytic leukemia based on the degree of lymphocytosis, the presence of anemia or thrombocytopenia, and the involvement of three or more lymph node regions.[2]

Staging System

Rai Staging System

According to the Rai Staging System, there are five stages of chronic lymphocytic leukemia based on the degree of lymphocytosis, hemoglobin level, platelets level, the presence of splenomegaly, and the presence of lymphadenopathy.[1]

Stage Hemoglobin Level Platelets Level Lymphocytosis Splenomegaly Lymphadenopathy Median Survival

Stage 0

>11 g/dL

>100,000/L

Present

Absent

Absent

>150 months

Stage 1

>11 g/dL

>100,000/L

Present

Absent

Present

101 months

Stage 2

>11 g/dL

>100,000/L

Present

Present

Present or absent

71 months

Stage 3

<11 g/dL

>100,000/L

Present

Present or absent

Present or absent

19 months

Stage 4

<11 g/dL or >11g/dL

<100,000/L

Present

Present or absent

Present or absent

19 months

Binet Staging System

According to the Binet Staging System, there are three stages of chronic lymphocytic leukemia based on the degree of lymphocytosis, the presence of anemia or thrombocytopenia, and the involvement of three or more lymph node regions.[2]

Stage Lymphocytosis Anemia or Thrombocytopenia Lymphadenopathy Median Survival

Stage A

Present

Absent

Absent

Almost normal age and sex adjusted survival rate

Stage B

Present

Absent

Present

7 years

Stage C

Present

Present

Present or Absent

2 years

References

  1. 1.0 1.1 Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS (1975). "Clinical staging of chronic lymphocytic leukemia". Blood. 46 (2): 219–34. PMID 1139039.
  2. 2.0 2.1 Binet JL, Auquier A, Dighiero G, Chastang C, Piguet H, Goasguen J; et al. (1981). "A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis". Cancer. 48 (1): 198–206. PMID 7237385.

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