Choriocarcinoma: Difference between revisions

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{{Infobox_Disease |
#REDIRECT[[Gestational trophoblastic neoplasia]]
  Name          = {{PAGENAME}} |
  Image          = |
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  DiseasesDB    = 2602 |
  ICD10          = {{ICD10|C|58||c|51}} |
  ICD9          = {{ICD9|181}} |
  ICDO          = 9100-9101 |
  OMIM          = |
  MedlinePlus    = |
  eMedicineSubj  = |
  eMedicineTopic = |
  MeshID        = D002822 |
}}
{{SI}}
{{CMG}}
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==Overview==
'''Choriocarcinoma''' is a malignant and aggressive [[cancer]] of the [[placenta]]. It is characterized by '''early hematogenous spread''' to the lungs. It belongs to the far end of the spectrum of [[gestational trophoblastic diseases]] (GTD).
 
==Classification of GTDs==
Broadly, gestational trophoblastic diseases can be classified in the following:
 
1. [[Hydatidiform Mole]]
:a. Complete Mole
:b. Partial Mole
2. Invasive Mole<br>
3. Choriocarcinoma
 
4. Placental site trophoblastic tumor
 
== Etiology/Epidemiology ==
It is preceded by:
* [[hydatidiform mole]] (50% of cases)
* Spontaneous abortion (20%of cases)
* [[ectopic pregnancy]] (2% of cases)
* normal term pregnancy (20-30% of cases)
 
==Symptoms/Signs/Labs==
* increased quantitative [[human chorionic gonadotropin|&beta;-hCG]] levels
* [[vaginal bleeding]]
* [[shortness of breath]]
* [[hemoptysis]] (coughing up blood)
* [[chest pain]]
* [[chest X-ray]] shows multiple infiltrates of various shapes in both lungs
* presents in males as a [[testicular_cancer|testicular neoplasm]]
 
==Pathology==
On [[light microscopy]], there is malignant [[trophoblast]]ic proliferation without hydropic villi.
 
==Treatment==
Choriocarcinoma is one of the tumors that is most sensitive to [[chemotherapy]]. The cure rate, even for metastatic choriocarcinoma, is around 90-95%. Virtually everyone without metastases can be cured however metastatic disease to the kidneys and/or brain is usually fatal. Chemotherapy regimen include EMACO ([[etoposide]], [[methotrexate]], [[actinomycin D]], [[cyclosphosphamide]] and [[oncovin]]). 
 
[[Hysterectomy]] (surgical removal of the uterus) can also be offered to patients > 40 years of age or those desiring sterilization. It may be required for those with severe infection and uncontrolled bleeding.
 
==External Links==
*[http://www.mymolarpregnancy.com MyMolarPregnancy.com] Support group, information, links and personal stories for women with molar pregnancies at mymolarpregnancy.com
*{{Chorus|00976}}
 
{{Soft tissue tumors and sarcomas}}
{{SIB}}
[[Category:Gynecology]]
[[Category:Types of cancer]]
[[Category:Oncology]]
 
 
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Latest revision as of 12:35, 21 October 2015