Cholestasis: Difference between revisions

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==[[Cholestasis overview|Overview]]==
==[[Cholestasis overview|Overview]]==



Revision as of 17:53, 27 January 2012

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Cholestasis
ICD-10 K71.0, K83.1
ICD-9 576.2
DiseasesDB 9121
eMedicine ped/383 
MeSH D002779

Cholestasis Microchapters

Home

Patient Information

Overview

Pathophysiology

Causes

Differentiating Cholestasis from other Diseases

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Cholestasis On the Web

Most recent articles

cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Cholestasis

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Cholestasis

CDC on Cholestasis

Cholestasis in the news

Blogs on Cholestasis

Directions to Hospitals Treating Cholestasis

Risk calculators and risk factors for Cholestasis

Overview

Etiology

Histopathology

Under a microscope, the individual hepatocytes will have a brownish-green stippled appearance within the cytoplasm, representing bile that cannot get out of the cell. Canalicular bile plugs between individual hepatocytes or within bile ducts may also be seen, representing bile that has been excreted from the hepatocytes but cannot go any further due to the obstruction. When these plugs occur within the bile duct, sufficient pressure (caused by bile accumulation) can cause them to rupture, spilling bile into the surrounding tissue, causing hepatic necrosis. These areas are known as bile lakes, and are typically seen only with extra-hepatic obstruction.

Symptoms

Bile is secreted by the liver to aid in the digestion of fats. Drugs such as gold salts,nitrofurantoin, anabolic steroids, chlorpromazine, prochlorperazine, sulindac, cimetidine, erythromycin, can cause cholestasis and may result in damage to the liver.

Differential Diagnosis of Cholestasis

See also

External links

Template:SIB Template:Gastroenterology sv:Gallstas


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