Chlamydia trachomatis: Difference between revisions

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:::* Alternative regimen (2):[[ Erythromycin]] base 500  mg PO qid for 7 days {{or}}  [[Erythromycin]]base 250 mg PO  qid for 14 days
:::* Alternative regimen (2):[[ Erythromycin]] base 500  mg PO qid for 7 days {{or}}  [[Erythromycin]]base 250 mg PO  qid for 14 days
:::* Alternative regimen (3):[[ Erythromycin]]  ethylsuccinate 800  mg PO qid for 7 days {{or}}  [[Erythromycin]] ethylsuccinate 400 mg PO four qid for 14days
:::* Alternative regimen (3):[[ Erythromycin]]  ethylsuccinate 800  mg PO qid for 7 days {{or}}  [[Erythromycin]] ethylsuccinate 400 mg PO four qid for 14days
:::* Note: Doxycycline, ofloxacin, and levofloxacin are contraindicated in pregnant women.
:::* Note:[[ Doxycycline]], [[Ofloxacin]], and [[Levofloxacin]] are contraindicated in pregnant women.




::* '''Chlamydial infection among neonates'''
::* '''Chlamydial infection among neonates'''
::*'''Ophthalmia Neonatorum'''
::*'''Ophthalmia Neonatorum'''caused by ''C. trachomatis''
:::* Preferred regimen :[[ Erythromycin]]  base or ethylsuccinate ,PO 50 mg/kg/ day divided into 4 doses daily for 14 days
:::* Preferred regimen :[[ Erythromycin]]  base or ethylsuccinate ,PO 50 mg/kg/ day divided into 4 doses daily for 14 days
:::* Alternative regimen : [[Azithromycin ]]suspension, PO 20 mg/kg /day qd for 3 days
:::* Alternative regimen : [[Azithromycin ]]suspension, PO 20 mg/kg /day qd for 3 days
:::* Note: The mothers of infants who have chlamydial infection and the sex partners of these women should be evaluated and treated.
:::* Note: The mothers of infants who have chlamydial infection and the sex partners of these women should be evaluated and treated.
::*'''Infant Pneumonia'''
::*'''Infant Pneumonia'''
:::* Preferred regimen :[[ Erythromycin]]  base or ethylsuccinate PO 50 mg/kg/ day divided into 4 doses daily for 14 days
:::* Preferred regimen :[[ Erythromycin]]  base or ethylsuccinate PO 50 mg/kg/ day divided into 4 doses daily for 14 days

Revision as of 12:09, 25 June 2015


Chlamydia trachomatis
C. trachomatis inclusion bodies (brown) in a McCoy cell culture.
C. trachomatis inclusion bodies (brown) in a McCoy cell culture.
Scientific classification
Kingdom: Bacteria
Phylum: Chlamydiae
Order: Chlamydiales
Family: Chlamydiaceae
Genus: Chlamydia
Species: C. trachomatis
Binomial name
Chlamydia trachomatis
Busacca, 1935

Chlamydia trachomatis is one of three bacterial species in the genus Chlamydia, family Chlamydiaceae, class Chlamydiae, phylum Chlamydiae, domain Bacteria. C. trachomatis has only been found living inside the cells of humans, causing the following conditions:

In men

In women

In both sexes

C. trachomatis has also been detected in some patients with temporomandibular joint (TMJ) disease. It may be treated with any of several antibiotics: azithromycin, erythromycin or doxycycline/tetracycline.

C. trachomatis was the first chlamydial agent discovered in humans. It comprises two human biovars: trachoma and lymphogranuloma venereum (LGV). Many, but not all, C. trachomatis strains have an extrachromosomal plasmid. Chlamydia species are readily identified and distinguished from other chlamydial species using DNA-based tests. Most strains of C. trachomatis are recognized by monoclonal antibodies [mAbs] to epitopes in the VS4 region of MOMP. However, these mAbs may also crossreact with the other two Chlamydia species, Chlamydia suis and Chlamydia muridarum.


Treatment

  • Chlaymydial infections [1]
  • Chlamydial Infections in Adolescents and Adults
  • Preferred regimen : Doxycycline 100 mg PO bid for 7 days OR Azithromycin 1 g PO in a single dose
  • Alternative regimen (1): Erythromycin base 500 mg PO qid for 7 days OR Erythromycin ethylsuccinate 800 mg PO qid for 7 days
  • Alternative regimen (2): Levofloxacin 500 mg PO qd for 7 days OR Ofloxacin 300 mg PO bid for 7 days.
  • Note: Patients should be instructed to refer their sex partners for evaluation, testing, and treatment if they had sexual contact with the patient during the 60 days preceding onset of the patient's symptoms or chlamydia diagnosis.
  • Chlamydial Infections in patients with HIV Infection
  • Pregancy


  • Chlamydial infection among neonates
  • Ophthalmia Neonatorumcaused by C. trachomatis
  • Preferred regimen :Erythromycin base or ethylsuccinate ,PO 50 mg/kg/ day divided into 4 doses daily for 14 days
  • Alternative regimen : Azithromycin suspension, PO 20 mg/kg /day qd for 3 days
  • Note: The mothers of infants who have chlamydial infection and the sex partners of these women should be evaluated and treated.
  • Infant Pneumonia
  • Preferred regimen :Erythromycin base or ethylsuccinate PO 50 mg/kg/ day divided into 4 doses daily for 14 days
  • Alternative regimen : Azithromycin suspension, PO 20 mg/kg /day qd for 3 days
  • Chlamydial infection among infants and childern
  • Infants and childern who weigh < 45 kg
  • Preferred regimen :Erythromycin base or ethylsuccinate PO 50 mg/kg/ day divided into 4 doses daily for 14 days
  • Infants and childern who weigh >45 kg but who are aged <8 years
  • Infants and childern aged >8 years


Lymphogranuloma venereum (LGV) Lymphogranuloma venereum (LGV) is caused by C. trachomatis serovars L1, L2, or L3

  • Preferred regimen : Doxycycline 100 mg PO bid for 21 days
  • Alternative regimen: Erythromycin base 500 mg PO qid for 21 days
  • NOTE (1): azithromycin 1 g orally once weekly for 3 weeks is probably effective based on its chlamydial antimicrobial activity. Fluoroquinolone-based treatments might also be effective, but extended treatment intervals are likely required.
  • NOTE (2): Pregnant and lactating women should be treated with erythromycin. Azithromycin might prove useful for treatment of LGV in pregnancy, but no published data are available regarding its safety and efficacy. Doxycycline is contraindicated in pregnant women.
  • NOTE (3): Persons with both LGV and HIV infection should receive the same regimens as those who are HIV negative. Prolonged therapy might be required, and delay in resolution of symptoms might occur.

presemtive Sex Partners

Gallery

External links

ar:تراخوما da:Klamydia de:Chlamydia trachomatis nl:Chlamydia trachomatis no:Chlamydia trachomatis uk:Chlamydia trachomatis

Template:WikiDoc Sources

  1. "Chlamydial Infections".
  2. 2.0 2.1 2.2 2.3 2.4 2.5 "Public Health Image Library (PHIL)".