Cervical cancer classification: Difference between revisions
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==Overview== | ==Overview== | ||
Cervical cancer may be classified into many subtypes based on FIGO classification. | Cervical cancer may be classified into many subtypes based on [[FIGO]] classification. | ||
==Classification == | ==Classification == | ||
Newly revised FIGO staging for cervical cancer, included pathological and imaging findings as well as clinical manifestations.<ref name="MatsuoMachida2019">{{cite journal|last1=Matsuo|first1=Koji|last2=Machida|first2=Hiroko|last3=Mandelbaum|first3=Rachel S.|last4=Konishi|first4=Ikuo|last5=Mikami|first5=Mikio|title=Validation of the 2018 FIGO cervical cancer staging system|journal=Gynecologic Oncology|volume=152|issue=1|year=2019|pages=87–93|issn=00908258|doi=10.1016/j.ygyno.2018.10.026}}</ref><ref name="BhatlaAoki2018">{{cite journal|last1=Bhatla|first1=Neerja|last2=Aoki|first2=Daisuke|last3=Sharma|first3=Daya Nand|last4=Sankaranarayanan|first4=Rengaswamy|title=Cancer of the cervix uteri|journal=International Journal of Gynecology & Obstetrics|volume=143|year=2018|pages=22–36|issn=00207292|doi=10.1002/ijgo.12611}}</ref><ref name="ChamiéBlasbalg2011">{{cite journal|last1=Chamié|first1=Luciana Pardini|last2=Blasbalg|first2=Roberto|last3=Pereira|first3=Ricardo Mendes Alves|last4=Warmbrand|first4=Gisele|last5=Serafini|first5=Paulo Cesar|title=Findings of Pelvic Endometriosis at Transvaginal US, MR Imaging, and Laparoscopy|journal=RadioGraphics|volume=31|issue=4|year=2011|pages=E77–E100|issn=0271-5333|doi=10.1148/rg.314105193}}</ref> | Newly revised [[FIGO]] staging for cervical cancer, included [[pathological]] and imaging findings as well as [[clinical]] manifestations.<ref name="MatsuoMachida2019">{{cite journal|last1=Matsuo|first1=Koji|last2=Machida|first2=Hiroko|last3=Mandelbaum|first3=Rachel S.|last4=Konishi|first4=Ikuo|last5=Mikami|first5=Mikio|title=Validation of the 2018 FIGO cervical cancer staging system|journal=Gynecologic Oncology|volume=152|issue=1|year=2019|pages=87–93|issn=00908258|doi=10.1016/j.ygyno.2018.10.026}}</ref><ref name="BhatlaAoki2018">{{cite journal|last1=Bhatla|first1=Neerja|last2=Aoki|first2=Daisuke|last3=Sharma|first3=Daya Nand|last4=Sankaranarayanan|first4=Rengaswamy|title=Cancer of the cervix uteri|journal=International Journal of Gynecology & Obstetrics|volume=143|year=2018|pages=22–36|issn=00207292|doi=10.1002/ijgo.12611}}</ref><ref name="ChamiéBlasbalg2011">{{cite journal|last1=Chamié|first1=Luciana Pardini|last2=Blasbalg|first2=Roberto|last3=Pereira|first3=Ricardo Mendes Alves|last4=Warmbrand|first4=Gisele|last5=Serafini|first5=Paulo Cesar|title=Findings of Pelvic Endometriosis at Transvaginal US, MR Imaging, and Laparoscopy|journal=RadioGraphics|volume=31|issue=4|year=2011|pages=E77–E100|issn=0271-5333|doi=10.1148/rg.314105193}}</ref> | ||
FIGO staging of cancer of the cervix uteri (2018) | FIGO staging of cancer of the [[cervix]] [[Uterine|uteri]] (2018) | ||
{| class="wikitable" | {| class="wikitable" | ||
!Stage | !Stage | ||
| Line 15: | Line 15: | ||
|- | |- | ||
|I | |I | ||
|The carcinoma is strictly confined to the cervix (extension to the uterine corpus should be disregarded) | |The [[carcinoma]] is strictly confined to the [[cervix]] (extension to the [[uterine]] corpus should be disregarded) | ||
|- | |- | ||
|IA | |IA | ||
|Invasive carcinoma that can be diagnosed only by microscopy, with maximum depth of invasion <5 mma | |Invasive [[carcinoma]] that can be diagnosed only by [[microscopy]], with maximum depth of invasion <5 mma | ||
|- | |- | ||
|IA1 | |IA1 | ||
| Line 24: | Line 24: | ||
|- | |- | ||
|IA2 | |IA2 | ||
|Measured stromal invasion ≥3 mm and <5 mm in depth | |Measured [[stromal]] invasion ≥3 mm and <5 mm in depth | ||
|- | |- | ||
|IB | |IB | ||
|Invasive carcinoma with measured deepest invasion ≥5 mm (greater than Stage IA), lesion limited to the cervix | |Invasive carcinoma with measured deepest invasion ≥5 mm (greater than Stage IA), lesion limited to the cervix uteri | ||
|- | |- | ||
|IB1 | |IB1 | ||
| Line 33: | Line 33: | ||
|- | |- | ||
|IB2 | |IB2 | ||
|Invasive carcinoma ≥2 cm and <4 cm in greatest dimension | |Invasive [[carcinoma]] ≥2 cm and <4 cm in greatest dimension | ||
|- | |- | ||
|IB3 | |IB3 | ||
|Invasive carcinoma ≥4 cm in greatest dimension | |Invasive [[carcinoma]] ≥4 cm in greatest dimension | ||
|- | |- | ||
|II | |II | ||
|The carcinoma invades beyond the uterus, but has not extended onto the lower third of the vagina or to the pelvic wall | |The carcinoma invades beyond the [[uterus]], but has not extended onto the lower third of the vagina or to the [[pelvic]] wall | ||
|- | |- | ||
|IIA | |IIA | ||
| Line 45: | Line 45: | ||
|- | |- | ||
|IIA1 | |IIA1 | ||
|Invasive carcinoma <4 cm in greatest dimension | |[[Invasive]] carcinoma <4 cm in greatest dimension | ||
|- | |- | ||
|IIA2 | |IIA2 | ||
| Line 51: | Line 51: | ||
|- | |- | ||
|IIB | |IIB | ||
|With parametrial involvement but not up to the pelvic wall | |With parametrial involvement but not up to the [[pelvic]] wall | ||
|- | |- | ||
|III | |III | ||
|The carcinoma involves the lower third of the vagina and/or extends to the pelvic wall and/or causes hydronephrosis or nonfunctioning kidney and/or involves pelvic and/or para‐aortic lymph | |The [[carcinoma]] involves the lower third of the vagina and/or extends to the pelvic wall and/or causes [[hydronephrosis]] or nonfunctioning [[kidney]] and/or involves [[pelvic]] and/or para‐aortic [[lymph nodes]] | ||
|- | |- | ||
|IIIA | |IIIA | ||
|The carcinoma involves the lower third of the vagina, with no extension to the pelvic wall | |The carcinoma involves the lower third of the vagina, with no extension to the [[pelvic]] wall | ||
|- | |- | ||
|IIIB | |IIIB | ||
|Extension to the pelvic wall and/or hydronephrosis or nonfunctioning kidney (unless known to be due to another cause) | |Extension to the [[pelvic]] wall and/or [[hydronephrosis]] or nonfunctioning [[kidney]] (unless known to be due to another cause) | ||
|- | |- | ||
|IIIC | |IIIC | ||
|Involvement of pelvic and/or para‐aortic lymph | |Involvement of [[pelvic]] and/or para‐aortic [[lymph node]]<nowiki/>s, irrespective of [[tumor]] size and extent (with r and p notations)c | ||
|- | |- | ||
|IIIC1 | |IIIC1 | ||
|Pelvic lymph node metastasis only | |[[Pelvic]] lymph node metastasis only | ||
|- | |- | ||
|IIIC2 | |IIIC2 | ||
|Para‐aortic lymph node metastasis | |Para‐aortic [[lymph node]] metastasis | ||
|- | |- | ||
|IV | |IV | ||
|The carcinoma has extended beyond the true pelvis or has involved (biopsy proven) the mucosa of the bladder or rectum. (A bullous edema, as such, does not permit a case to be allotted to Stage IV) | |The [[carcinoma]] has extended beyond the true [[pelvis]] or has involved (biopsy proven) the mucosa of the [[bladder]] or [[rectum]]. (A [[bullous]] edema, as such, does not permit a case to be allotted to Stage IV) | ||
|- | |- | ||
|IVA | |IVA | ||
|Spread to adjacent pelvic organs | |Spread to adjacent [[pelvic]] organs | ||
|- | |- | ||
|IVB | |IVB | ||
Revision as of 19:31, 20 February 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Cervical cancer may be classified into many subtypes based on FIGO classification.
Classification
Newly revised FIGO staging for cervical cancer, included pathological and imaging findings as well as clinical manifestations.[1][2][3]
FIGO staging of cancer of the cervix uteri (2018)
| Stage | Description |
|---|---|
| I | The carcinoma is strictly confined to the cervix (extension to the uterine corpus should be disregarded) |
| IA | Invasive carcinoma that can be diagnosed only by microscopy, with maximum depth of invasion <5 mma |
| IA1 | Measured stromal invasion <3 mm in depth |
| IA2 | Measured stromal invasion ≥3 mm and <5 mm in depth |
| IB | Invasive carcinoma with measured deepest invasion ≥5 mm (greater than Stage IA), lesion limited to the cervix uteri |
| IB1 | Invasive carcinoma ≥5 mm depth of stromal invasion, and <2 cm in greatest dimension |
| IB2 | Invasive carcinoma ≥2 cm and <4 cm in greatest dimension |
| IB3 | Invasive carcinoma ≥4 cm in greatest dimension |
| II | The carcinoma invades beyond the uterus, but has not extended onto the lower third of the vagina or to the pelvic wall |
| IIA | Involvement limited to the upper two‐thirds of the vagina without parametrial involvement |
| IIA1 | Invasive carcinoma <4 cm in greatest dimension |
| IIA2 | Invasive carcinoma ≥4 cm in greatest dimension |
| IIB | With parametrial involvement but not up to the pelvic wall |
| III | The carcinoma involves the lower third of the vagina and/or extends to the pelvic wall and/or causes hydronephrosis or nonfunctioning kidney and/or involves pelvic and/or para‐aortic lymph nodes |
| IIIA | The carcinoma involves the lower third of the vagina, with no extension to the pelvic wall |
| IIIB | Extension to the pelvic wall and/or hydronephrosis or nonfunctioning kidney (unless known to be due to another cause) |
| IIIC | Involvement of pelvic and/or para‐aortic lymph nodes, irrespective of tumor size and extent (with r and p notations)c |
| IIIC1 | Pelvic lymph node metastasis only |
| IIIC2 | Para‐aortic lymph node metastasis |
| IV | The carcinoma has extended beyond the true pelvis or has involved (biopsy proven) the mucosa of the bladder or rectum. (A bullous edema, as such, does not permit a case to be allotted to Stage IV) |
| IVA | Spread to adjacent pelvic organs |
| IVB | Spread to distant organs |
References
- ↑ Matsuo, Koji; Machida, Hiroko; Mandelbaum, Rachel S.; Konishi, Ikuo; Mikami, Mikio (2019). "Validation of the 2018 FIGO cervical cancer staging system". Gynecologic Oncology. 152 (1): 87–93. doi:10.1016/j.ygyno.2018.10.026. ISSN 0090-8258.
- ↑ Bhatla, Neerja; Aoki, Daisuke; Sharma, Daya Nand; Sankaranarayanan, Rengaswamy (2018). "Cancer of the cervix uteri". International Journal of Gynecology & Obstetrics. 143: 22–36. doi:10.1002/ijgo.12611. ISSN 0020-7292.
- ↑ Chamié, Luciana Pardini; Blasbalg, Roberto; Pereira, Ricardo Mendes Alves; Warmbrand, Gisele; Serafini, Paulo Cesar (2011). "Findings of Pelvic Endometriosis at Transvaginal US, MR Imaging, and Laparoscopy". RadioGraphics. 31 (4): E77–E100. doi:10.1148/rg.314105193. ISSN 0271-5333.