Cervical cancer: Difference between revisions

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__NOTOC__
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
{{Infobox_Disease |
Name = Cervical cancer |
DiseasesDB = 2278 |
ICD10 = C53 |
ICD9 = {{ICD9|180}} |
ICDO = |
OMIM = 603956 |
MedlinePlus = 000893 |
MeshID = |
}}
{{Cervical cancer}}
{{Cervical cancer}}
{{CMG}}
{{CMG}}{{AE}}{{Nnasiri}}
 
{{SK}} Uterine cervix carcinoma.


==[[Cervical cancer overview|Overview]]==
==[[Cervical cancer overview|Overview]]==


==[[Cervical cancer historical perspective|Historical Perspective]]==
==[[Cervical cancer historical perspective|Historical Perspective]]==
==[[Cervical cancer classification|Classification]]==


==[[Cervical cancer pathophysiology|Pathophysiology]]==
==[[Cervical cancer pathophysiology|Pathophysiology]]==
==[[Cervical cancer causes|Causes]]==
==[[Cervical cancer differential diagnosis|Differentiating Cervical Cancer from other Disorders]]==


==[[Cervical cancer epidemiology and demographics|Epidemiology and Demographics]]==
==[[Cervical cancer epidemiology and demographics|Epidemiology and Demographics]]==
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==[[Cervical cancer screening|Screening]]==
==[[Cervical cancer screening|Screening]]==
===Staging===
Cervical cancer is staged by the [[International Federation of Gynecology and Obstetrics]] (FIGO) staging system, which is based on clinical examination, rather than surgical findings. It allows only the following diagnostic tests to be used in determining the stage: palpation, inspection, [[colposcopy]], endocervical [[curettage]], [[hysteroscopy]], [[cystoscopy]], [[proctoscopy]], intravenous [[urography]], and [[X-ray]] examination of the lungs and skeleton, and cervical [[conization]].
The [[TNM]] staging system for cervical cancer is analogous to the FIGO stage.
* Stage 0 - full-thickness involvement of the [[epithelium]] without invasion into the [[Stroma (animal tissue)|stroma]] ([[carcinoma in situ]])
* Stage I - limited to the uterus
** IA - diagnosed only by microscopy; no visible lesions
*** IA1 - stromal invasion less than 3 mm in depth and 7 mm or less in horizontal spread
*** IA2 - stromal invasion between 3 and 5 mm with horizontal spread of 7 mm or less
** IB - visible lesion or a microscopic lesion with more than 5 mm of depth or horizontal spread of more than 7 mm
*** IB1 - visible lesion 4 cm or less in greatest dimension
*** IB2 - visible lesion more than 4 cm
* Stage II - invades beyond cervix
** IIA - without parametrial invasion, but involve upper 2/3 of vagina
** IIB - with parametrial invasion
* Stage III - extends to pelvic wall or lower third of the vagina
** IIIA - involves lower third of vagina
** IIIB - extends to pelvic wall and/or causes [[hydronephrosis]] or non-functioning kidney
* IVA - invades mucosa of bladder or rectum and/or extends beyond true pelvis
* IVB - distant [[metastasis]]
Note that the FIGO stage does not incorporate [[lymph node]] involvement in contrast to the [[TNM]] staging for most other cancers.
For cases treated surgically, information obtained from the pathologist can be used in assigning a separate pathologic stage but is not to replace the original clinical stage.
For premalignant dysplastic changes, the CIN ([[cervical intraepithelial neoplasia]]) grading is used.
==[[Cervical cancer causes|Causes]]==
==[[Cervical cancer differential diagnosis|Differentiating Cervical cancer from other Disorders]]==


==[[Cervical cancer natural history|Natural History, Complications, and Prognosis]]==
==[[Cervical cancer natural history|Natural History, Complications, and Prognosis]]==


==Diagnosis==
==Diagnosis==
[[Cervical cancer history and symptoms|History and Symptoms]] | [[Cervical cancer physical examination|Physical Examination]] | [[Cervical cancer laboratory tests|Laboratory Tests]] | [[Cervical cancer electrocardiogram | Electrocardiogram]] | [[Cervical cancer chest x ray|Chest X Ray]] | [[Cervical cancer MRI|MRI]] | [[Cervical cancer CT|CT]] | [[Cervical cancer echocardiography|Echocardiography]] | [[Cervical cancer other imaging findings|Other Imaging Findings]] | [[Cervical cancer other diagnostic studies|Other Diagnostic Studies]]
[[Cervical cancer staging|Staging]] | [[Cervical cancer history and symptoms|History and Symptoms]] | [[Cervical cancer physical examination|Physical Examination]] | [[Cervical cancer laboratory findings|Laboratory Findings]] | [[Cervical cancer chest x ray|Chest X Ray]] | [[Cervical cancer CT|CT]] | [[Cervical cancer MRI|MRI]] | [[Cervical cancer ultrasound|Ultrasound]] | [[Cervical cancer other diagnostic studies|Other Diagnostic Studies]]


==Treatment==
==Treatment==
'''Medical:''' [[Cervical cancer medical therapy|Medical Therapy]]
[[Cervical cancer medical therapy|Medical Therapy]] | [[Cervical cancer surgery|Surgery]] | [[Cervical Cancer During Pregnancy|Pregnancy]] | [[Cervical cancer primary prevention|Primary Prevention]] | [[Cervical cancer secondary prevention|Secondary Prevention]] | [[Cervical cancer cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Cervical cancer future or investigational therapies|Future or Investigational Therapies]]


'''Surgical:''' [[Cervical cancer surgery|Surgery]]
==Case Studies==
[[Cervical cancer case study one|Case #1]]


[[Cervical cancer primary prevention|Primary Prevention]] | [[Cervical cancer secondary prevention|Secondary Prevention]] | [[Cervical cancer cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Cervical cancer future or investigational therapies|Future or Investigational Therapies]]
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==References==
{{reflist|2}}


[[Category:Disease]]
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[[Category:Oncology]]
[[Category:Oncology]]
[[Category:Mature chapter]]
[[Category:Mature chapter]]
 
[[Category:Up-To-Date]]
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[[Category:Medicine]]
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Latest revision as of 20:51, 29 July 2020


For patient information click here

Cervical cancer Microchapters

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Cervical Cancer from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Chest X Ray

CT

MRI

Ultrasound

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Cervical Cancer During Pregnancy

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Cervical cancer On the Web

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American Roentgen Ray Society Images of Cervical cancer

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Ongoing Trials at Clinical Trials.gov

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NICE Guidance

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Cervical cancer in the news

Blogs on Cervical cancer

Directions to Hospitals Treating Cervical cancer

Risk calculators and risk factors for Cervical cancer

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Nima Nasiri, M.D.[2]

Synonyms and keywords: Uterine cervix carcinoma.

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Cervical Cancer from other Disorders

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications, and Prognosis

Diagnosis

Staging | History and Symptoms | Physical Examination | Laboratory Findings | Chest X Ray | CT | MRI | Ultrasound | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Pregnancy | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

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