Centromere protein E

Centromere protein E, 312kDa
PDB rendering based on 1t5c.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1t5c​
Identifiers
Symbols	CENPE ; KIF10
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20429
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Centromere protein E, 312kDa, also known as CENPE, is a human gene.

Centrosome-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation.

Further reading

• Yen TJ, Li G, Schaar BT; et al. (1992). "CENP-E is a putative kinetochore motor that accumulates just before mitosis". Nature. 359 (6395): 536–9. doi:10.1038/359536a0. PMID 1406971.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yen TJ, Compton DA, Wise D; et al. (1991). "CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase". EMBO J. 10 (5): 1245–54. PMID 2022189.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Testa JR, Zhou JY, Bell DW, Yen TJ (1995). "Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24-->q25 and 1q32-->q41, respectively, by fluorescence in situ hybridization". Genomics. 23 (3): 691–3. doi:10.1006/geno.1994.1558. PMID 7851898.CS1 maint: Multiple names: authors list (link)
• Thrower DA, Jordan MA, Schaar BT; et al. (1995). "Mitotic HeLa cells contain a CENP-E-associated minus end-directed microtubule motor". EMBO J. 14 (5): 918–26. PMID 7889940.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wood KW, Sakowicz R, Goldstein LS, Cleveland DW (1997). "CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment". Cell. 91 (3): 357–66. PMID 9363944.CS1 maint: Multiple names: authors list (link)
• Cooke CA, Schaar B, Yen TJ, Earnshaw WC (1998). "Localization of CENP-E in the fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphase". Chromosoma. 106 (7): 446–55. PMID 9391217.CS1 maint: Multiple names: authors list (link)
• Zecevic M, Catling AD, Eblen ST; et al. (1998). "Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E". J. Cell Biol. 142 (6): 1547–58. PMID 9744883.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chan GK, Schaar BT, Yen TJ (1998). "Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1". J. Cell Biol. 143 (1): 49–63. PMID 9763420.CS1 maint: Multiple names: authors list (link)
• Chan GK, Jablonski SA, Sudakin V; et al. (1999). "Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC". J. Cell Biol. 146 (5): 941–54. PMID 10477750.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ashar HR, James L, Gray K; et al. (2000). "Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules". J. Biol. Chem. 275 (39): 30451–7. doi:10.1074/jbc.M003469200. PMID 10852915.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Uren AG, Wong L, Pakusch M; et al. (2001). "Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype". Curr. Biol. 10 (21): 1319–28. PMID 11084331.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Tsunoda T, Sese J; et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.164001. PMID 11337467.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu ST, Chan GK, Hittle JC; et al. (2003). "Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores". Mol. Biol. Cell. 14 (4): 1638–51. doi:10.1091/mbc.02-05-0074. PMID 12686615.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Garcia-Saez I, Blot D, Kahn R, Kozielski F (2005). "Crystallization and preliminary crystallographic analysis of the motor domain of human kinetochore-associated protein CENP-E using an automated crystallization procedure". Acta Crystallogr. D Biol. Crystallogr. 60 (Pt 6): 1158–60. doi:10.1107/S0907444904009564. PMID 15159587.CS1 maint: Multiple names: authors list (link)
• Tanudji M, Shoemaker J, L'Italien L; et al. (2005). "Gene silencing of CENP-E by small interfering RNA in HeLa cells leads to missegregation of chromosomes after a mitotic delay". Mol. Biol. Cell. 15 (8): 3771–81. doi:10.1091/mbc.E03-07-0482. PMID 15181147.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Garcia-Saez I, Yen T, Wade RH, Kozielski F (2004). "Crystal structure of the motor domain of the human kinetochore protein CENP-E". J. Mol. Biol. 340 (5): 1107–16. doi:10.1016/j.jmb.2004.05.053. PMID 15236970.CS1 maint: Multiple names: authors list (link)
• Kurasawa Y, Earnshaw WC, Mochizuki Y; et al. (2005). "Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation". EMBO J. 23 (16): 3237–48. doi:10.1038/sj.emboj.7600347. PMID 15297875.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mao Y, Desai A, Cleveland DW (2005). "Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling". J. Cell Biol. 170 (6): 873–80. doi:10.1083/jcb.200505040. PMID 16144904.CS1 maint: Multiple names: authors list (link)
• Nousiainen M, Silljé HH, Sauer G; et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)