Cav1.2

Calcium channel, voltage-dependent, L type, alpha 1C subunit
PDB rendering based on 2be6.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2be6​
Identifiers
Symbols	CACNA1C ; CACH2; CACN2; CACNL1A1; CCHL1A1; CaV1.2; MGC120730; TS
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55484
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Calcium channel, voltage-dependent, L type, alpha 1C subunit (also known as Ca_v1.2) is a subunit of L-type voltage-dependent calcium channel encoded by the CACNA1C gene, mutation in which are associated with a variant of Long QT syndrome called Timothy's syndrome and also with Brugada syndrome.

See also

• Calcium channel

Further reading

• Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (2006). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID 16382099.CS1 maint: Multiple names: authors list (link)
• Soldatov NM (1992). "Molecular diversity of L-type Ca2+ channel transcripts in human fibroblasts". Proc. Natl. Acad. Sci. U.S.A. 89 (10): 4628–32. PMID 1316612.
• Powers PA, Gregg RG, Hogan K (1992). "Linkage mapping of the human gene for the alpha 1 subunit of the cardiac DHP-sensitive Ca2+ channel (CACNL1A1) to chromosome 12p13.2-pter using a dinucleotide repeat". Genomics. 14 (1): 206–7. PMID 1330882.CS1 maint: Multiple names: authors list (link)
• Sun W, McPherson JD, Hoang DQ; et al. (1993). "Mapping of a human brain voltage-gated calcium channel to human chromosome 12p13-pter". Genomics. 14 (4): 1092–4. PMID 1335957.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lacerda AE, Kim HS, Ruth P; et al. (1991). "Normalization of current kinetics by interaction between the alpha 1 and beta subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel". Nature. 352 (6335): 527–30. doi:10.1038/352527a0. PMID 1650913.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Powers PA, Gregg RG, Lalley PA; et al. (1991). "Assignment of the human gene for the alpha 1 subunit of the cardiac DHP-sensitive Ca2+ channel (CCHL1A1) to chromosome 12p12-pter". Genomics. 10 (3): 835–9. PMID 1653763.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Perez-Reyes E, Wei XY, Castellano A, Birnbaumer L (1990). "Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes". J. Biol. Chem. 265 (33): 20430–6. PMID 2173707.CS1 maint: Multiple names: authors list (link)
• Soldatov NM, Bouron A, Reuter H (1995). "Different voltage-dependent inhibition by dihydropyridines of human Ca2+ channel splice variants". J. Biol. Chem. 270 (18): 10540–3. PMID 7737988.CS1 maint: Multiple names: authors list (link)
• Soldatov NM (1994). "Genomic structure of human L-type Ca2+ channel". Genomics. 22 (1): 77–87. doi:10.1006/geno.1994.1347. PMID 7959794.
• Tang S, Mikala G, Bahinski A; et al. (1993). "Molecular localization of ion selectivity sites within the pore of a human L-type cardiac calcium channel". J. Biol. Chem. 268 (18): 13026–9. PMID 8099908.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schultz D, Mikala G, Yatani A; et al. (1993). "Cloning, chromosomal localization, and functional expression of the alpha 1 subunit of the L-type voltage-dependent calcium channel from normal human heart". Proc. Natl. Acad. Sci. U.S.A. 90 (13): 6228–32. PMID 8392192.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Perets T, Blumenstein Y, Shistik E; et al. (1996). "A potential site of functional modulation by protein kinase A in the cardiac Ca2+ channel alpha 1C subunit". FEBS Lett. 384 (2): 189–92. PMID 8612821.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Soldatov NM, Zühlke RD, Bouron A, Reuter H (1997). "Molecular structures involved in L-type calcium channel inactivation. Role of the carboxyl-terminal region encoded by exons 40-42 in alpha1C subunit in the kinetics and Ca2+ dependence of inactivation". J. Biol. Chem. 272 (6): 3560–6. PMID 9013606.CS1 maint: Multiple names: authors list (link)
• Klöckner U, Mikala G, Eisfeld J; et al. (1997). "Properties of three COOH-terminal splice variants of a human cardiac L-type Ca2+-channel alpha1-subunit". Am. J. Physiol. 272 (3 Pt 2): H1372–81. PMID 9087614.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gao T, Yatani A, Dell'Acqua ML; et al. (1997). "cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits". Neuron. 19 (1): 185–96. PMID 9247274.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zühlke RD, Bouron A, Soldatov NM, Reuter H (1998). "Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit gene". FEBS Lett. 427 (2): 220–4. PMID 9607315.CS1 maint: Multiple names: authors list (link)
• Meyers MB, Puri TS, Chien AJ; et al. (1998). "Sorcin associates with the pore-forming subunit of voltage-dependent L-type Ca2+ channels". J. Biol. Chem. 273 (30): 18930–5. PMID 9668070.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu WS, Soldatov NM, Gustavsson I, Chowdhary BP (1999). "Fiber-FISH analysis of the 3'-terminal region of the human L-type Ca2+ channel alpha 1C subunit gene". Hereditas. 129 (2): 169–75. PMID 10022083.CS1 maint: Multiple names: authors list (link)

External links

• CACNA1C+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)