Cataract classification: Difference between revisions

Jump to navigation Jump to search
No edit summary
m (Bot: Removing from Primary care)
 
(12 intermediate revisions by one other user not shown)
Line 14: Line 14:
{| class="wikitable"
{| class="wikitable"
!
!
!
!Sub-types
!
!
|-
|-
Line 22: Line 22:
* Subcapsular  
* Subcapsular  
* Nuclear  
* Nuclear  
* Cortical
* Corical
* Lamellar  
* Lamellar  
* Sutural
* Sutural
|
|
* Congenital capsular thickening may be associated with posterior or anterior polar cataracts and pyramidal cataract. The posterior form may be associated with a hylaoid remnant.
* '''Capsular '''
* Acquired capsular opacities can occur with pseudoexfoliation, Infra-red radiation (Glass blower’s cataract) or Secondary to blunt trauma when a Vossius’ ring may be formed.
# Congenital capsular thickening-  Associated with posterior or anterior polar cataracts and pyramidal cataract. The posterior form may be associated with a hyaloid remnant.
* Nuclear   - Congenital : Cataract is that secondary to Rubella  - Age related : Nuclear sclerosis cataract.
# Acquired capsular opacities - Occur with pseudoexfoliation, Infra-red radiation (Glass blower’s cataract) or Secondary to blunt trauma when a Vossius’ ring may be formed. 
*  
* '''Subcapsular '''
# Posterior subcapsular - Lens changes may be associated with secondary or complicated cataracts, drugs e.g., steroids, or be an age-related cataract (Cupuliform). 
# Anterior subcapsular''' '''  Anterior subcapsular lens changes may be associated with   Wilson’s disease (sunflower cataract) or with drugs e.g., amiodarone
* '''Nuclear '''
# Congenital - Nuclear cataract is that secondary to Rubella 
# Age-related - Nuclear sclerosis cataract commonly seen in practice is the age-related form.  
* '''Cortical '''
# Congenital - Congenital cortical cataract is very common and they rarely interfere with vision. e.g., blue dot cataract and coronary cataract.
# Age-related - Known as cuneiform cataract that takes the form of “water” clefts and vacuoles. These often appear first in the inferior nasal quadrant of the lens possibly because this is most exposed to UV radiation. 
* '''Lamellar '''
# Congenital - The cataracts are usually congenital and often involve one lamella of the fetal or nuclear zones. Radial, spoke-like opacities (or riders) also often surround the cataract. 
* '''Sutural '''
# These are often known as “Y”-shaped” cataract. 
|-
|-
|Maturity
|Maturity
Line 38: Line 50:
*Congenital cataract
*Congenital cataract
|
|
* '''Immature or incomplete -''' The cataract is present but not visually incapacitating. Surgery may or may not be indicated. 
* '''Mature -''' The whole lens is opaque. Surgery is usually indicated. 
* '''Intumescent -''' The lens is swollen. Surgery is indicated. 
* '''Hypermature -''' The lens is shrunken, yellow and the capsule is wrinkled. 
* '''Morganian cataract -''' A hypermature cataract with liquified cortex and in which the nucleus settles inferiorly. 
|-
|-
|Location of opacity   
|Location of opacity   
Line 61: Line 78:
* Hereditary 
* Hereditary 
|
|
* Congenital cataract can be a result of heredity (often autosomal dominant), pre-natal infections such as rubella or metabolic disorders. 
* '''Congenital cataract''' - Result of heredity (often autosomal dominant), prenatal infections such as rubella or metabolic disorders. 
- Intrauterine infections e.g. rubella and toxoplasmosis
*# Intrauterine infections e.g. [[Congenital rubella syndrome|Rubella]] and [[Toxoplasmosis congenital|Toxoplasmosis]]
 
*# Maternal drug ingestion e.g. [[Thalidomide]] and corticosteroids. 
- Maternal drug ingestion e.g. thalidomide and corticosteroids. 
*# Genetically transmitted syndromes 
 
*# [[Microphthalmia|Microphthalmos]]
- Genetically transmitted syndromes 
*# Ocular conditions with associated anomalies e.g. [[Retinopathy of Prematurity]] and some types of retinitis pigmentosa. 
 
*# Secondary to metabolic disorders e.g. [[Galactosemia]] and [[Wilson's disease|Wilson’s disease]]
- Microphthalmos is often associated with cataract. 
* '''Degenerative or "Age-Related" (senile)'''- Most adults have some degree of opacification of the lens and therefore technically exhibit cataract. 
 
*# Subcapsular Anterior subcapsular cataract (directly under the capsule) is associated with fibrous metaplasia of anterior lens epithelium. Posterior subcapsular cataract (cupuliform) lies just in front of the posterior capsule and is associated with posterior migration of epithelial cells.   
- Ocular conditions with associated anomalies e.g. retinopathy of  
*# Cortical cataract commonly develops as radial or spoke-shaped “water-clefts” (cuneiform) together with vacuoles. Cuneiform changes affect anterior, posterior and equatorial cortex affected.  
 
*# Nuclear sclerosis  Nuclear cataract is an exacerbation of the normal aging of lens nucleus and appears as a yellowing of the nucleus. 
prematurity & some types of retinitis pigmentosa
*'''Traumatic''' - Trauma is the commonest cause of unilateral cataract in young individuals. Opacities can be the result of various injuries including penetrating injury. Concussion to the eye may cause the iris to be flattened against the lens leaving a Vossius’ ring
 
*'''Secondary''' - Cataract can occur secondary to systemic disease or syndromes including metabolic disorders and due to local disease (ocular).  
- Secondary to metabolic disorders  e.g. Galactosemia & Wilson’s disease  
**Secondary to systemic diseases/metabolic disorders
|-
**#Diabetes - Diabetes mellitus can cause an exacerbation of the progression of age-related degenerative changes. So-called (classical) diabetic cataract occurs during an acute and untreated hyperglycaemic episode and takes the form of cortical “snowflakes”. These occur due to osmotic over-hydration of the lens and can be anterior and/or posterior in position. 
|
**#Galactosaemia - This metabolic disease produces an “oil droplet” cataract. 
|
**#Wilson’s disease (hepatolenticular degeneration) - This is an anomaly of copper metabolism and produces a ring of copper in the peripheral cornea (Kayser-Fleischer ring) and a greenish colored “sunflower cataract” 
|
**#Atopic dermatitis - Cataract can occur secondary to atopic dermatitis and takes the form of bilateral posterior or anterior stellate opacities. 
**#Down’s syndrome - 15% of Down’s have lens opacities severe enough to cause a decrease in acuity (Kanski, 1998) and with a reported prevalence of up to 50% (Scully, 1973).  
**Secondary to local disease (or complicated cataract) 
**#Anterior uveitis - Anterior uveitis can produce a posterior polar polychromatic cataract. Also, if uveitis not controlled, anterior and posterior subcapsular opacities can progress to complete opacification. 
**#High myopia - Hight myopia can be associated with secondary posterior lens opacities as well as the earlier development of nuclear sclerosis. 
**#Glaukomflecken - These are grey-white anterior capsular or subcapsular opacities in pupillary zone pathognomonic with previous attacks of acute angle-closure glaucoma. 
*'''Toxic '''
*#Corticosteroids - Steroids used for prolonged therapy produce a posterior subcapsular cataract. 
*#Amiodarone - Amiodarone can cause anterior capsular changes in up to 50% of patients. The opacities tend to be visually insignificant. 
|}
|}
::*
::
:*Congenital cataract
::*Sutural cataract
::*Lamellar cataract
::*Zonular cataract
::*Total cataract
::* Secondary cataract
 
::*Drug-induced cataract (e.g. Corticosteroids)
:*Traumatic cataract
::*Blunt trauma (capsule usually intact)
::*Penetrating trauma (capsular rupture & leakage of lens material - calls for an emergency surgery for extraction of lens and leaked material to minimize further damage)
 
:*Nuclear cataract - Grading correlates with hardness & difficulty of surgical removal
::*1 - Grey
::*2 - Yellow
::*3 - Amber
::*4 - Brown/Black (Note: "Black cataract" translated in some languages (like Hindi) refers to [[Glaucoma]], not the color of the lens nucleus)
 
::*After-cataract - posterior capsular opacification subsequent to  a successful extracapsular cataract surgery (usually within 3 months - 2 years) with or without IOL implantation. Requires a quick & painless office procedure with [[Nd:YAG laser]] capsulotomy to restore optical clarity.


==References==
==References==
{{reflist|2}}
{{reflist|2}}
{{WS}}
{{WH}}


[[Category:Ophthalmology]]
[[Category:Ophthalmology]]
[[Category:Primary care]]
{{WS}}
{{WH}}

Latest revision as of 20:49, 29 July 2020

Cataract Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Cataract from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Cataract classification On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Cataract classification

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Cataract classification

CDC on Cataract classification

Cataract classification in the news

Blogs on Cataract classification

Directions to Hospitals Treating Cataract

Risk calculators and risk factors for Cataract classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Rohan Bir Singh, M.B.B.S.[2]

Overview

Classification

The classification of cataracts is based on four different criteria.

  1. Morphology,
  2. Age of Onset
  3. Maturity
  4. Etiology
  5. Location of opacity
Sub-types
Morphology
  • Capsular
  • Subcapsular
  • Nuclear
  • Corical
  • Lamellar
  • Sutural
  • Capsular 
  1. Congenital capsular thickening- Associated with posterior or anterior polar cataracts and pyramidal cataract. The posterior form may be associated with a hyaloid remnant.
  2. Acquired capsular opacities - Occur with pseudoexfoliation, Infra-red radiation (Glass blower’s cataract) or Secondary to blunt trauma when a Vossius’ ring may be formed. 
  • Subcapsular 
  1. Posterior subcapsular - Lens changes may be associated with secondary or complicated cataracts, drugs e.g., steroids, or be an age-related cataract (Cupuliform). 
  2. Anterior subcapsular  Anterior subcapsular lens changes may be associated with  Wilson’s disease (sunflower cataract) or with drugs e.g., amiodarone
  • Nuclear 
  1. Congenital - Nuclear cataract is that secondary to Rubella 
  2. Age-related - Nuclear sclerosis cataract commonly seen in practice is the age-related form.  
  • Cortical 
  1. Congenital - Congenital cortical cataract is very common and they rarely interfere with vision. e.g., blue dot cataract and coronary cataract.
  2. Age-related - Known as cuneiform cataract that takes the form of “water” clefts and vacuoles. These often appear first in the inferior nasal quadrant of the lens possibly because this is most exposed to UV radiation. 
  • Lamellar 
  1. Congenital - The cataracts are usually congenital and often involve one lamella of the fetal or nuclear zones. Radial, spoke-like opacities (or riders) also often surround the cataract. 
  • Sutural 
  1. These are often known as “Y”-shaped” cataract. 
Maturity
  • Immature Senile Cataract (IMSC) - partially opaque lens, disc view hazy
  • Mature Senile Cataract (MSC) - Completely opaque lens, no disc view
  • Hypermature Senile Cataract (HMSC) - Liquefied cortical matter: Morgagnian Cataract
  • Congenital cataract
  • Immature or incomplete - The cataract is present but not visually incapacitating. Surgery may or may not be indicated. 
  • Mature - The whole lens is opaque. Surgery is usually indicated. 
  • Intumescent - The lens is swollen. Surgery is indicated. 
  • Hypermature - The lens is shrunken, yellow and the capsule is wrinkled. 
  • Morganian cataract - A hypermature cataract with liquified cortex and in which the nucleus settles inferiorly. 
Location of opacity
  • Anterior cortical cataract
  • Anterior polar cataract
  • Anterior subcapsular cataract
  • Nuclear cataract
  • Posterior cortical cataract
  • Posterior polar cataract (importance lies in higher risk of complication - posterior capsular tears during surgery)
  • Posterior subcapsular cataract (PSC) (clinically common)
  • Anterior subcapsular lens changes may be associated with Wilson’s disease (sunflower cataract) or with drugs e.g., amiodarone
  • Posterior subcapsular cataract changes may associated with secondary or complicated cataracts, drugs e.g., steroids, or be an age related cataract.
Etiological
  • Congenital 
  • Degenerative or “age related” (senile) 
  • Traumatic 
  • Secondary to other conditions (including metabolic causes) 
  • Toxic 
  • Hereditary 
  • Congenital cataract - Result of heredity (often autosomal dominant), prenatal infections such as rubella or metabolic disorders. 
    1. Intrauterine infections e.g. Rubella and Toxoplasmosis
    2. Maternal drug ingestion e.g. Thalidomide and corticosteroids. 
    3. Genetically transmitted syndromes 
    4. Microphthalmos
    5. Ocular conditions with associated anomalies e.g. Retinopathy of Prematurity and some types of retinitis pigmentosa. 
    6. Secondary to metabolic disorders e.g. Galactosemia and Wilson’s disease
  • Degenerative or "Age-Related" (senile)- Most adults have some degree of opacification of the lens and therefore technically exhibit cataract. 
    1. Subcapsular Anterior subcapsular cataract (directly under the capsule) is associated with fibrous metaplasia of anterior lens epithelium. Posterior subcapsular cataract (cupuliform) lies just in front of the posterior capsule and is associated with posterior migration of epithelial cells. 
    2. Cortical cataract commonly develops as radial or spoke-shaped “water-clefts” (cuneiform) together with vacuoles. Cuneiform changes affect anterior, posterior and equatorial cortex affected.
    3. Nuclear sclerosis  Nuclear cataract is an exacerbation of the normal aging of lens nucleus and appears as a yellowing of the nucleus. 
  • Traumatic - Trauma is the commonest cause of unilateral cataract in young individuals. Opacities can be the result of various injuries including penetrating injury. Concussion to the eye may cause the iris to be flattened against the lens leaving a Vossius’ ring. 
  • Secondary - Cataract can occur secondary to systemic disease or syndromes including metabolic disorders and due to local disease (ocular). 
    • Secondary to systemic diseases/metabolic disorders
      1. Diabetes - Diabetes mellitus can cause an exacerbation of the progression of age-related degenerative changes. So-called (classical) diabetic cataract occurs during an acute and untreated hyperglycaemic episode and takes the form of cortical “snowflakes”. These occur due to osmotic over-hydration of the lens and can be anterior and/or posterior in position. 
      2. Galactosaemia - This metabolic disease produces an “oil droplet” cataract. 
      3. Wilson’s disease (hepatolenticular degeneration) - This is an anomaly of copper metabolism and produces a ring of copper in the peripheral cornea (Kayser-Fleischer ring) and a greenish colored “sunflower cataract” 
      4. Atopic dermatitis - Cataract can occur secondary to atopic dermatitis and takes the form of bilateral posterior or anterior stellate opacities. 
      5. Down’s syndrome - 15% of Down’s have lens opacities severe enough to cause a decrease in acuity (Kanski, 1998) and with a reported prevalence of up to 50% (Scully, 1973). 
    • Secondary to local disease (or complicated cataract) 
      1. Anterior uveitis - Anterior uveitis can produce a posterior polar polychromatic cataract. Also, if uveitis not controlled, anterior and posterior subcapsular opacities can progress to complete opacification. 
      2. High myopia - Hight myopia can be associated with secondary posterior lens opacities as well as the earlier development of nuclear sclerosis. 
      3. Glaukomflecken - These are grey-white anterior capsular or subcapsular opacities in pupillary zone pathognomonic with previous attacks of acute angle-closure glaucoma. 
  • Toxic 
    1. Corticosteroids - Steroids used for prolonged therapy produce a posterior subcapsular cataract. 
    2. Amiodarone - Amiodarone can cause anterior capsular changes in up to 50% of patients. The opacities tend to be visually insignificant. 

References

Template:WS Template:WH