Caseous necrosis

Revision as of 23:33, 8 August 2012 by WikiBot (talk | contribs) (Bot: Automated text replacement (-{{SIB}} + & -{{EH}} + & -{{EJ}} + & -{{Editor Help}} + & -{{Editor Join}} +))
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search
Caseous necrosis
A high-power view of the granuloma with the amorphous eosinophilic material representing caseation necrosis (1), giant cells near the center (2), and inflammatory cells around the periphery.
Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology

WikiDoc Resources for Caseous necrosis


Most recent articles on Caseous necrosis

Most cited articles on Caseous necrosis

Review articles on Caseous necrosis

Articles on Caseous necrosis in N Eng J Med, Lancet, BMJ


Powerpoint slides on Caseous necrosis

Images of Caseous necrosis

Photos of Caseous necrosis

Podcasts & MP3s on Caseous necrosis

Videos on Caseous necrosis

Evidence Based Medicine

Cochrane Collaboration on Caseous necrosis

Bandolier on Caseous necrosis

TRIP on Caseous necrosis

Clinical Trials

Ongoing Trials on Caseous necrosis at Clinical

Trial results on Caseous necrosis

Clinical Trials on Caseous necrosis at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Caseous necrosis

NICE Guidance on Caseous necrosis


FDA on Caseous necrosis

CDC on Caseous necrosis


Books on Caseous necrosis


Caseous necrosis in the news

Be alerted to news on Caseous necrosis

News trends on Caseous necrosis


Blogs on Caseous necrosis


Definitions of Caseous necrosis

Patient Resources / Community

Patient resources on Caseous necrosis

Discussion groups on Caseous necrosis

Patient Handouts on Caseous necrosis

Directions to Hospitals Treating Caseous necrosis

Risk calculators and risk factors for Caseous necrosis

Healthcare Provider Resources

Symptoms of Caseous necrosis

Causes & Risk Factors for Caseous necrosis

Diagnostic studies for Caseous necrosis

Treatment of Caseous necrosis

Continuing Medical Education (CME)

CME Programs on Caseous necrosis


Caseous necrosis en Espanol

Caseous necrosis en Francais


Caseous necrosis in the Marketplace

Patents on Caseous necrosis

Experimental / Informatics

List of terms related to Caseous necrosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Caseous necrosis describes a form of biological tissue death. The dead tissue appears as a soft and white proteinaceous dead cell mass. Like most patterns of necrosis, no histological architecture is preserved - it is characterised by acellular pink areas of necrosis surrounded by a granulomatous inflammatory process. Frequently, caseous necrosis is associated with tuberculosis (TB).

When the hilar lymph node for instance is infected with tuberculosis and leads to caseous necrosis, it would appear to have a cheesy tan to white appearance, which is why this type of necrosis is often depicted as a combination of both coagulative and liquefactive necrosis.

However, in the lung, extensive caseous necrosis with confluent cheesy tan granulomas is typical. The tissue destruction is so extensive that there are areas of cavitation (also known as cystic spaces). See Ghon's complex.

Pathological Findings: Case #1: Lung: Caseous necrosis

Clinical Summary

A 70-year-old man was admitted to the hospital with a history of upper abdominal pain, anorexia, nausea, and general malaise, all of approximately three weeks' duration. His hospital stay was characterized by fever and severe respiratory distress. There were multiple densities in the patient's chest x-ray consistent with pneumonia and examination of a stained sputum specimen showed acid fast bacilli. Despite intensive therapy, the patient progressively deteriorated and died 14 days after admission.

Autopsy Findings

It was determined at autopsy that the patient suffered from pulmonary tuberculosis with widespread dissemination throughout the body. The left lung weighed 620 grams and the right lung 1230 grams. These were characterized by marked congestion and edema. In addition, multiple gray-white nodules ranging from pinpoint size up to 1 cm were diffusely distributed throughout the lung parenchyma.

Images courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology

External links


Template:WH Template:WS