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{{Cardiac disease in pregnancy}}
{{Cardiac disease in pregnancy}}
{{CMG}}; {{AOEIC}} {{CZ}}
{{CMG}}; {{AOEIC}} {{CZ}}
==Physiology of Labor and Delivery==
*Hemodynamics are altered substantially during labor and delivery secondary to [[anxiety]], [[pain]], and [[contractions|uterine contractions]].  Oxygen consumption increases threefold, and [[cardiac output]] rises progressively during [[labor]] owing to increases in both [[stroke volume]] and [[heart rate]]. [[Blood pressure]] is higher in the lateral position. Both the [[systolic blood pressure|systolic]] and [[diastolic blood pressure]] increase markedly during [[uterine contractions]] with a greater augmentation during the second stage. The form of anesthesia impacts the [[blood pressure]]. <br>
*By the time of delivery the [[cardiac output]] has increased by 50%, the [[plasma volume]] has increased by 40% and the [[red cell mass]] has increased by 25 to 30%. <br>
*The work of labor may increase the [[cardiac output]] by 60% over the baseline level. <br>
*During the second stage of [[labor]] the patient is on her back there is [[venous stasis]], [[heart rate]] increases to greater than 120/min and the [[blood pressure]] may be more than 150 mm Hg. <br>
*Immediately following delivery, the uterus contracts and delivers a sudden bolus of 500-750 cc of blood to the circulatory system which may result in [[pulmonary edema]] in the patient with heart disease.
===Hemodynamic effect of Cesarean Section:===
To avoid the hemodynamic changes assocaited with vaginal delivery, cesarean section is frequently recommended for women with cardiovascular disease. This form of delivery can also be associated with hemodynamic fluctuations related to intubation, analgesic as well as anesthetic use. There can be a greater extent of blood loss as well as relief of caval compression.
===Hemodynamic changes Postpartum:===
There can be a temporary increase in venous return immediately after delivery due to relief of caval compression in addition to blood shifting from the contracting uterus into the systemic circulation. This change and effective blood volume occurs despite blood loss during delivery and can result in a substantial rise in ventricular filling pressures, [[stroke volume]], and [[cardiac output]] that may lead to clinical deterioration.
Both [[heart rate]] and [[cardiac output]] returned to prelabor values by one hour after delivery and the [[blood pressure]] and [[stroke volume]] at 24 hours after delivery.
Hemodynamic adaptation of pregnancy persists postpartum and gradually returns to prepregnancy values within 12-24 weeks after delivery.


==Effect of Pregnancy on Maternal Physiology==
==Effect of Pregnancy on Maternal Physiology==
Line 69: Line 48:
:* Flared ribs.
:* Flared ribs.
:* Breast hypertropy<ref name="Morris"> Morris S, Stacey M. Resuscitation in pregnancy. BJM 2003;327:1277-1279.</ref> (may impede effective resuscitation).
:* Breast hypertropy<ref name="Morris"> Morris S, Stacey M. Resuscitation in pregnancy. BJM 2003;327:1277-1279.</ref> (may impede effective resuscitation).
==Physiology of Labor and Delivery==
*Hemodynamics are altered substantially during labor and delivery secondary to [[anxiety]], [[pain]], and [[contractions|uterine contractions]].  Oxygen consumption increases threefold, and [[cardiac output]] rises progressively during [[labor]] owing to increases in both [[stroke volume]] and [[heart rate]]. [[Blood pressure]] is higher in the lateral position. Both the [[systolic blood pressure|systolic]] and [[diastolic blood pressure]] increase markedly during [[uterine contractions]] with a greater augmentation during the second stage. The form of anesthesia impacts the [[blood pressure]]. <br>
*By the time of delivery the [[cardiac output]] has increased by 50%, the [[plasma volume]] has increased by 40% and the [[red cell mass]] has increased by 25 to 30%. <br>
*The work of labor may increase the [[cardiac output]] by 60% over the baseline level. <br>
*During the second stage of [[labor]] the patient is on her back there is [[venous stasis]], [[heart rate]] increases to greater than 120/min and the [[blood pressure]] may be more than 150 mm Hg. <br>
*Immediately following delivery, the uterus contracts and delivers a sudden bolus of 500-750 cc of blood to the circulatory system which may result in [[pulmonary edema]] in the patient with heart disease.
===Hemodynamic effect of Cesarean Section:===
To avoid the hemodynamic changes assocaited with vaginal delivery, cesarean section is frequently recommended for women with cardiovascular disease. This form of delivery can also be associated with hemodynamic fluctuations related to intubation, analgesic as well as anesthetic use. There can be a greater extent of blood loss as well as relief of caval compression.
===Hemodynamic changes Postpartum:===
There can be a temporary increase in venous return immediately after delivery due to relief of caval compression in addition to blood shifting from the contracting uterus into the systemic circulation. This change and effective blood volume occurs despite blood loss during delivery and can result in a substantial rise in ventricular filling pressures, [[stroke volume]], and [[cardiac output]] that may lead to clinical deterioration.
Both [[heart rate]] and [[cardiac output]] returned to prelabor values by one hour after delivery and the [[blood pressure]] and [[stroke volume]] at 24 hours after delivery.
Hemodynamic adaptation of pregnancy persists postpartum and gradually returns to prepregnancy values within 12-24 weeks after delivery.


==Fetal Physiology==
==Fetal Physiology==

Revision as of 15:50, 17 April 2012

Cardiac disease in pregnancy Microchapters

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Special Scenarios:

I. Pre-existing Cardiac Disease:
Congenital Heart Disease
Repaired Congenital Heart Disease
Pulmonary Hypertension
Rheumatic Heart Disease
Connective Tissue Disorders
II. Valvular Heart Disease:
Mitral Stenosis
Mitral Regurgitation
Aortic Insufficiency
Aortic Stenosis
Mechanical Prosthetic Valves
Tissue Prosthetic Valves
III. Cardiomyopathy:
Dilated Cardiomyopathy
Hypertrophic Cardiomyopathy
Peripartum Cardiomyopathy
IV. Cardiac diseases that may develop During Pregnancy:
Arrhythmias
Acute Myocardial Infarction
Hypertension

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]

Effect of Pregnancy on Maternal Physiology

Corpus uteum produces progesterone

Increased estrogen levels

  • may increase contractility of heart.

Increased renin and aldosterone levels caused by increased estrogen

  • enhances Na and water retention.
  • compensates for the decreased systemic vascular resistance.
  • by the middle trimester, plasma volume is increased by 40 to 45%.
  • hemodilution → anemia, but total red cell mass is not decreased. Rate of rise in volume is more rapid than rate of rise in red cell mass. This occurs until week 30 and is referred to as the physiologic anemia of pregnancy. The hematocrit can be as low as 33% to 38%.
  • starts as early as 6 weeks.
  • greater increase in blood volume among multigravidas.

Cardiac output increases by 50%

  • have a higher volume of more dilute blood to circulate.
  • need well oxygenated blood to circulate to the fetus.
  • begins to rise at 5th week, and cardiac output increases until week 24 at which time it plateaus.
  • resting heart rate increases by 10 to 15 beats per minute. Pregnancy with multiple fetuses is associated with even more rapid heart rates.
  • blood pressure remains relatively unchanged when measured in the left lateral recumbent position.
  • hemodynamics measured in the supine position are erroneous because the uterus compresses the IVC decreasing the return from the lower extremities. Therefore may have syncope when a gravid stands up from a supine position.
  • keep in mind that much of the blood is shunted to the placenta where it may pass from arterioles to venules bypassing the capillaries. May precipitate high cardiac output failure in some women.
  • cardiac output increases in the lateral position and declines in the supine position owing to caval compression by the gravid uterus.
  • the increase in cardiac output in early pregnancy is due to an increase in stroke volume early on, but in the third trimester it is due to an increase in heart rate.

Increased respiratory rate

  • secondary to increased abdominal pressure, elevation of the diaphragm.
  • lowers carbon dioxide tension.

Blood pressure

Gastrointestinal changes

  • Gastric emptying is slower – in pregnancy women have reduced gastrointestinal motility.
  • An incompetent gastro-oesophageal sphincter leads to gastro-oesophageal reflux with greater danger of aspiration of gastric contents into the trachea.
  • Increased intragastric pressure in late pregnancy[1]

Other changes in pregnancy

  • Flared ribs.
  • Breast hypertropy[2] (may impede effective resuscitation).

Physiology of Labor and Delivery

  • The work of labor may increase the cardiac output by 60% over the baseline level.
  • Immediately following delivery, the uterus contracts and delivers a sudden bolus of 500-750 cc of blood to the circulatory system which may result in pulmonary edema in the patient with heart disease.

Hemodynamic effect of Cesarean Section:

To avoid the hemodynamic changes assocaited with vaginal delivery, cesarean section is frequently recommended for women with cardiovascular disease. This form of delivery can also be associated with hemodynamic fluctuations related to intubation, analgesic as well as anesthetic use. There can be a greater extent of blood loss as well as relief of caval compression.

Hemodynamic changes Postpartum:

There can be a temporary increase in venous return immediately after delivery due to relief of caval compression in addition to blood shifting from the contracting uterus into the systemic circulation. This change and effective blood volume occurs despite blood loss during delivery and can result in a substantial rise in ventricular filling pressures, stroke volume, and cardiac output that may lead to clinical deterioration.

Both heart rate and cardiac output returned to prelabor values by one hour after delivery and the blood pressure and stroke volume at 24 hours after delivery.

Hemodynamic adaptation of pregnancy persists postpartum and gradually returns to prepregnancy values within 12-24 weeks after delivery.

Fetal Physiology

  • Uterine blood flow increases by a factor of 50 during pregnancy.
  • The uterine blood vessels remain dilated throughout pregnancy.
  • Transfer of oxygen across the placenta is flow-limited.
  • Fetal oxygen tension is normally quite low (30 to 40 mmHg).
  • Supplemental oxygen to the mother is quite effective in increasing fetal oxygen, particularly with fetal distress.
  • Normal fetal pH is 7.35. Fetal scalp pHs <7.25 are abnormal.
  • Labor can precipitate fetal distress because during uterine contractions, uterine blood flow is nearly occluded.
  • In a mother with cyanosis, it is easier for problems to arise during labor because of the reduced reserve in oxygen delivery.
  • With contractions, there may normally be a reduction or deceleration in the fetal heart rate, but this rapidly returns to normal.
  • In fetal distress, the decelerations are later in the contraction and persist, i.e. late decelerations.
  • Fetuses do not die suddenly during labor, and there are many minutes or hours of fetal distress before death so that there is time to intervene.
  • Placing the mother in the left lateral recumbent position and oxygen will relieve many cases of fetal distress.
  • Fetal monitoring should be used in the presence of maternal heart disease, cardiac surgery, cardioversion.

References

  1. Jevon P, Raby M. Physiological and anatomical changes in pregnancy relevant to resuscitation. In: O'Donnell E, Pooni JS, editors. Resuscitation in Pregnancy. A practical approach. Oxford: Reed Educational and Professional Publishing Ltd.; 2001. p. 10-16.
  2. Morris S, Stacey M. Resuscitation in pregnancy. BJM 2003;327:1277-1279.


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