Cardiac amyloidosis history and symptoms: Difference between revisions

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** [[Orthopnea]]<ref name="pmid7878478">{{cite journal |author=Kyle RA, Gertz MA |title=Primary systemic amyloidosis: clinical and laboratory features in 474 cases |journal=[[Seminars in Hematology]] |volume=32 |issue=1 |pages=45–59 |year=1995 |month=January |pmid=7878478 |doi= |url= |accessdate=2012-02-13}}</ref>
** [[Orthopnea]]<ref name="pmid7878478">{{cite journal |author=Kyle RA, Gertz MA |title=Primary systemic amyloidosis: clinical and laboratory features in 474 cases |journal=[[Seminars in Hematology]] |volume=32 |issue=1 |pages=45–59 |year=1995 |month=January |pmid=7878478 |doi= |url= |accessdate=2012-02-13}}</ref>
** [[Peripheral edema]]
** [[Peripheral edema]]
** [[Weight loss]] due to cardiac cachexia
** [[Weight loss]] due to [[cardiac cachexia]]
** [[Ascites]]
** [[Ascites]]
*[[arrhythmia|Arrhythmias]] such as [[Palpitation|palpitations]]
*[[arrhythmia|Arrhythmias]] with associated symptoms such as [[Palpitation|palpitations]]
* [[Syncope]] and [[presyncope]]: Syncope on exertion is an ominous sign of cardiac amyloidosis, as these patients cannot augment their cardiac output due to stiff walls.<ref name="pmid21747665">{{cite journal |author=Mugnai G, Cicoira M, Rossi A, Vassanelli C |title=Syncope in cardiac amyloidosis and chronic ischemic heart disease: A case report |journal=[[Experimental and Clinical Cardiology]] |volume=16 |issue=2 |pages=51–3 |year=2011 |pmid=21747665 |pmc=3126684 |doi= |url=}}</ref>
* [[Syncope]] and [[presyncope]]: Syncope on exertion is an ominous sign of cardiac amyloidosis, as these patients cannot augment their [[cardiac output]] due to poor filling of the ventricular due to stiff walls associated with their [[restricted cardiomyopathy]].<ref name="pmid21747665">{{cite journal |author=Mugnai G, Cicoira M, Rossi A, Vassanelli C |title=Syncope in cardiac amyloidosis and chronic ischemic heart disease: A case report |journal=[[Experimental and Clinical Cardiology]] |volume=16 |issue=2 |pages=51–3 |year=2011 |pmid=21747665 |pmc=3126684 |doi= |url=}}</ref>
*[[Postural hypotension]] may be observed in patients with subendothelial amyloid deposition.<ref name="pmid17062380">{{cite journal |author=Rapezzi C, Perugini E, Salvi F, Grigioni F, Riva L, Cooke RM, Ferlini A, Rimessi P, Bacchi-Reggiani L, Ciliberti P, Pastorelli F, Leone O, Bartolomei I, Pinna AD, Arpesella G, Branzi A |title=Phenotypic and genotypic heterogeneity in transthyretin-related cardiac amyloidosis: towards tailoring of therapeutic strategies? |journal=[[Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis]] |volume=13 |issue=3 |pages=143–53 |year=2006 |month=September |pmid=17062380 |doi=10.1080/13506120600877136 |url=http://informahealthcare.com/doi/abs/10.1080/13506120600877136 |accessdate=2012-02-13}}</ref>
*[[Postural hypotension]] may be observed in patients with subendothelial amyloid deposition.<ref name="pmid17062380">{{cite journal |author=Rapezzi C, Perugini E, Salvi F, Grigioni F, Riva L, Cooke RM, Ferlini A, Rimessi P, Bacchi-Reggiani L, Ciliberti P, Pastorelli F, Leone O, Bartolomei I, Pinna AD, Arpesella G, Branzi A |title=Phenotypic and genotypic heterogeneity in transthyretin-related cardiac amyloidosis: towards tailoring of therapeutic strategies? |journal=[[Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis]] |volume=13 |issue=3 |pages=143–53 |year=2006 |month=September |pmid=17062380 |doi=10.1080/13506120600877136 |url=http://informahealthcare.com/doi/abs/10.1080/13506120600877136 |accessdate=2012-02-13}}</ref>
* [[Chest pain]] or chest discomfort <ref name="pmid10974179">{{cite journal |author=Mueller PS, Edwards WD, Gertz MA |title=Symptomatic ischemic heart disease resulting from obstructive intramural coronary amyloidosis |journal=[[The American Journal of Medicine]] |volume=109 |issue=3 |pages=181–8 |year=2000 |month=August |pmid=10974179 |doi= |url=}}</ref><ref name="pmid10610629">{{cite journal |author=Al Suwaidi J, Velianou JL, Gertz MA, ''et al.'' |title=Systemic amyloidosis presenting with angina pectoris |journal=[[Annals of Internal Medicine]] |volume=131 |issue=11 |pages=838–41 |year=1999 |month=December |pmid=10610629 |doi= |url=}}</ref>
* [[Chest pain]] or chest discomfort <ref name="pmid10974179">{{cite journal |author=Mueller PS, Edwards WD, Gertz MA |title=Symptomatic ischemic heart disease resulting from obstructive intramural coronary amyloidosis |journal=[[The American Journal of Medicine]] |volume=109 |issue=3 |pages=181–8 |year=2000 |month=August |pmid=10974179 |doi= |url=}}</ref><ref name="pmid10610629">{{cite journal |author=Al Suwaidi J, Velianou JL, Gertz MA, ''et al.'' |title=Systemic amyloidosis presenting with angina pectoris |journal=[[Annals of Internal Medicine]] |volume=131 |issue=11 |pages=838–41 |year=1999 |month=December |pmid=10610629 |doi= |url=}}</ref>

Revision as of 20:12, 29 October 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]; Aarti Narayan, M.B.B.S [3]; Cafer Zorkun, M.D., Ph.D. [4]; Lakshmi Gopalakrishnan, M.B.B.S. [5]

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Overview

Amyloidosis is a multi-system disease involving many organs simultaneously. Approximately more than 50% of the patients with amyloidosis present with right heart failure symptoms. The most common symptoms observed in patients with cardiac amyloidosis include fatigue, weight loss, and periorbital purpura.[1]

Symptoms

Cardiac amyloid cab be associated with the following symptoms:[2]

References

  1. 1.0 1.1 Kyle RA, Gertz MA (1995). "Primary systemic amyloidosis: clinical and laboratory features in 474 cases". Seminars in Hematology. 32 (1): 45–59. PMID 7878478. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)
  2. Dubrey SW, Cha K, Anderson J; et al. (1998). "The clinical features of immunoglobulin light-chain (AL) amyloidosis with heart involvement". QJM : Monthly Journal of the Association of Physicians. 91 (2): 141–57. PMID 9578896. Unknown parameter |month= ignored (help)
  3. Mugnai G, Cicoira M, Rossi A, Vassanelli C (2011). "Syncope in cardiac amyloidosis and chronic ischemic heart disease: A case report". Experimental and Clinical Cardiology. 16 (2): 51–3. PMC 3126684. PMID 21747665.
  4. Rapezzi C, Perugini E, Salvi F, Grigioni F, Riva L, Cooke RM, Ferlini A, Rimessi P, Bacchi-Reggiani L, Ciliberti P, Pastorelli F, Leone O, Bartolomei I, Pinna AD, Arpesella G, Branzi A (2006). "Phenotypic and genotypic heterogeneity in transthyretin-related cardiac amyloidosis: towards tailoring of therapeutic strategies?". Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 13 (3): 143–53. doi:10.1080/13506120600877136. PMID 17062380. Retrieved 2012-02-13. Unknown parameter |month= ignored (help)
  5. Mueller PS, Edwards WD, Gertz MA (2000). "Symptomatic ischemic heart disease resulting from obstructive intramural coronary amyloidosis". The American Journal of Medicine. 109 (3): 181–8. PMID 10974179. Unknown parameter |month= ignored (help)
  6. Al Suwaidi J, Velianou JL, Gertz MA; et al. (1999). "Systemic amyloidosis presenting with angina pectoris". Annals of Internal Medicine. 131 (11): 838–41. PMID 10610629. Unknown parameter |month= ignored (help)


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