Cardiac amyloidosis differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]; Aarti Narayan, M.B.B.S [3]; Lakshmi Gopalakrishnan, M.B.B.S. [4]

Overview

Cardiomyopathy with congestive heart failure is the most common presentation of cardiac amyloidosis. Other common causes of a cardiomyopathy should be excluded, and cardiac amyloidosis should be considered in the absence of a history of myocaridal ischemia, myocardial infarction or presence of coronary artery disease risk factors.[1] Cardiac amyloidosis should be included in the differential diagnoses in patients with unexplained congestive heart failure who have no history of Valvular heart disease, long-standing hypertension or myocardial ischemia.[1]

Differentiating Cardiac Amyloidosis from Other Diseases

Cardiac amyloidosis should be differentiated from the following:

Cardiac amyloidosis is differentiated from the above disorders by the presence of the following:

  • Presence of low voltage on the EKG. Other causes of a low QRS voltage are shown here.
  • Echo features such as:
    • Diffuse increased echogenicity
    • Valve thickening
    • Thickened interatrial septum
  • Global late gadolinium enhancement (LGE) on MRI

References

  1. 1.0 1.1 Gertz MA, Lacy MQ, Dispenzieri A (1999). "Amyloidosis: recognition, confirmation, prognosis, and therapy". Mayo Clinic Proceedings. Mayo Clinic. 74 (5): 490–4. doi:10.4065/74.5.490. PMID 10319082. Retrieved 2012-02-13. Unknown parameter |month= ignored (help)


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