Cardiac allograft vasculopathy history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]; Raviteja Guddeti, M.B.B.S. [3]

Overview

History and Symptoms

CAV may manifest as:

  1. Graft failure
  2. Arrhythmias
  3. Silent myocardial infarction: Due to denervation at the time of surgery patients with CAV rarely present with typical angina symptoms, especially in the initial years of transplantation.[1] However, studies have demonstrated that re-innervation does occur late after heart transplantation.[2]
  4. Sudden death

References

  1. Di Cori A, Petronio AS, Gemignani C, Zucchelli G, Di Bello V, Mariani M (2005). "Symptomatic acute myocardial infarction in a cardiac transplant recipient successfully treated with primary coronary angioplasty: evidence of prognostic importance of chest pain after cardiac transplantation". J Heart Lung Transplant. 24 (8): 1146–9. doi:10.1016/j.healun.2004.07.003. PMID 16102462.
  2. Gallego-Page JC, Segovia J, Alonso-Pulpón L, Alonso-Rodríguez M, Salas C, Ortíz-Berrocal J (2004). "Re-innervation after heart transplantation: a multidisciplinary study". J Heart Lung Transplant. 23 (6): 674–82. PMID 15366426.

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