Carcinoma of the penis pathophysiology: Difference between revisions

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'''Editor(s)-in-Chief:''' [[C. Michael Gibson, M.S., M.D.]] [mailto:charlesmichaelgibson@gmail.com] Phone:617-632-7753; Joel Gelman, M.D. [mailto:jgelman@uci.edu], ''Director of the Center for Reconstructive Urology and Associate Clinical Professor in the Department of Urology at the University of    California,Irvine''
'''Editor(s)-in-Chief:''' [[C. Michael Gibson, M.S., M.D.]] [mailto:charlesmichaelgibson@gmail.com] Phone:617-632-7753; Joel Gelman, M.D. [mailto:jgelman@uci.edu], ''Director of the Center for Reconstructive Urology and Associate Clinical Professor in the Department of Urology at the University of    California,Irvine''
==Overview==
==Overview==
==Pathogenesis==
* Penile cancer arises from precursor lesions, which generally progress from low-grade to high-grade lesions.
* For HPV related penile cancers this sequence is as follows:<ref name="pmid18607597">{{cite journal| author=Bleeker MC, Heideman DA, Snijders PJ, Horenblas S, Dillner J, Meijer CJ| title=Penile cancer: epidemiology, pathogenesis and prevention. | journal=World J Urol | year= 2009 | volume= 27 | issue= 2 | pages= 141-50 | pmid=18607597 | doi=10.1007/s00345-008-0302-z | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18607597  }} </ref>
:* A. [[Squamous]] [[hyperplasia]]
:* B. Low-grade penile intraepithelial neoplasia (PIN)
:* C. High-grade PIN (carcinoma [[in situ]]—[[Bowen's disease]], [[Erythroplasia of Queyrat]] and [[bowenoid papulosis]] (BP))
:* D. Invasive carcinoma of the penis


==Gross Pathology==
==Gross Pathology==


===Microscopic Pathology ===
==Microscopic Pathology ==


==References==
==References==

Revision as of 18:34, 22 September 2015

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Editor(s)-in-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753; Joel Gelman, M.D. [2], Director of the Center for Reconstructive Urology and Associate Clinical Professor in the Department of Urology at the University of California,Irvine

Overview

Pathogenesis

  • Penile cancer arises from precursor lesions, which generally progress from low-grade to high-grade lesions.
  • For HPV related penile cancers this sequence is as follows:[1]

Gross Pathology

Microscopic Pathology

References

  1. Bleeker MC, Heideman DA, Snijders PJ, Horenblas S, Dillner J, Meijer CJ (2009). "Penile cancer: epidemiology, pathogenesis and prevention". World J Urol. 27 (2): 141–50. doi:10.1007/s00345-008-0302-z. PMID 18607597.


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