Carbenicillin

Carbenicillin

File:Carbenicillin.svg
Clinical data
Pregnancy category	US: B (No risk in non-human studies) Passes into breast milk
Routes of administration	Oral
ATC code	J01CA03 (WHO)
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Bioavailability	30 to 40%
Protein binding	30 to 60%
Metabolism	Minimal
Elimination half-life	1 hour
Excretion	Renal (30 to 40%)
Identifiers
IUPAC name (2S,5R,6R)-6-{[carboxy(phenyl)acetyl]amino}- 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylic acid
CAS Number	4697-36-3
PubChem CID	20824
DrugBank	APRD00846
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C17H18N2O6S
Molar mass	378.401 g/mol

WikiDoc Resources for Carbenicillin
Articles
Most recent articles on Carbenicillin Most cited articles on Carbenicillin Review articles on Carbenicillin Articles on Carbenicillin in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Carbenicillin Images of Carbenicillin Photos of Carbenicillin Podcasts & MP3s on Carbenicillin Videos on Carbenicillin
Evidence Based Medicine
Cochrane Collaboration on Carbenicillin Bandolier on Carbenicillin TRIP on Carbenicillin
Clinical Trials
Ongoing Trials on Carbenicillin at Clinical Trials.gov Trial results on Carbenicillin Clinical Trials on Carbenicillin at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Carbenicillin NICE Guidance on Carbenicillin NHS PRODIGY Guidance FDA on Carbenicillin CDC on Carbenicillin
Books
Books on Carbenicillin
News
Carbenicillin in the news Be alerted to news on Carbenicillin News trends on Carbenicillin
Commentary
Blogs on Carbenicillin
Definitions
Definitions of Carbenicillin
Patient Resources / Community
Patient resources on Carbenicillin Discussion groups on Carbenicillin Patient Handouts on Carbenicillin Directions to Hospitals Treating Carbenicillin Risk calculators and risk factors for Carbenicillin
Healthcare Provider Resources
Symptoms of Carbenicillin Causes & Risk Factors for Carbenicillin Diagnostic studies for Carbenicillin Treatment of Carbenicillin
Continuing Medical Education (CME)
CME Programs on Carbenicillin
International
Carbenicillin en Espanol Carbenicillin en Francais
Business
Carbenicillin in the Marketplace Patents on Carbenicillin
Experimental / Informatics
List of terms related to Carbenicillin

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Carbenicillin is an antibiotic belonging to the carboxypenicillin subgroup of the penicillins. It has gram-negative coverage which includes Pseudomonas aeruginosa but limited gram-positive coverage. The carboxypenicillins are susceptible to degradation by beta-lactamase enzymes.

The antibiotic is very soluble in water and is acid-labile. Aqueous solutions are short-lived. Working concentration in the lab: up to 100 µg per ml.

It is a semi-synthetic analogue of the naturally occurring penicillin. Although much more expensive than ampicillin, it is much more stable.

Template:WS