CYP8B1
| cytochrome P450, family 8, subfamily B, polypeptide 1 | |
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| Identifiers | |
| Symbol | CYP8B1 |
| Entrez | 1582 |
| HUGO | 2653 |
| OMIM | 602172 |
| RefSeq | NM_004391 |
| UniProt | Q9UNU6 |
| Other data | |
| EC number | 1.14.13.95 |
| Locus | Chr. 3 p22.1 |
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Ongoing Trials on CYP8B1 at Clinical Trials.gov Clinical Trials on CYP8B1 at Google
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US National Guidelines Clearinghouse on CYP8B1
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CYP8B1 (cytochrome P450, family 8, subfamily B, polypeptide 1) also known as sterol 12-alpha-hydroxylase is a protein which in humans is encoded by the CYP39A1 gene.[1] This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless.[2]
References
- ↑ Gåfvels M, Olin M, Chowdhary BP, Raudsepp T, Andersson U, Persson B, Jansson M, Björkhem I, Eggertsen G (1999). "Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns". Genomics. 56 (2): 184–96. doi:10.1006/geno.1998.5606. PMID 10051404. Unknown parameter
|month=ignored (help) - ↑ "Entrez Gene: CYP8B1".
This article incorporates text from the United States National Library of Medicine, which is in the public domain.