CYP8B1: Difference between revisions

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{{protein
{{Infobox_gene}}
|Name=cytochrome P450, family 8, subfamily B, polypeptide 1
|caption=
|image=
|width=
|HGNCid=2653
|Symbol=CYP8B1
|AltSymbols=
|EntrezGene=1582
|OMIM= 602172
|RefSeq=NM_004391
|UniProt= Q9UNU6
|PDB=
|ECnumber=1.14.13.95
|Chromosome=3
|Arm=p
|Band=22.1
|LocusSupplementaryData=
}}
{{SI}}


'''CYP8B1'''  ('''cy'''tochrome '''P'''450, family '''8''', subfamily '''B''', polypeptide '''1''') also known as''' sterol 12-alpha-hydroxylase''' is a [[protein]] which in humans is encoded by the ''CYP8B1'' [[gene]].<ref name="pmid10051404">{{cite journal | vauthors = Gåfvels M, Olin M, Chowdhary BP, Raudsepp T, Andersson U, Persson B, Jansson M, Björkhem I, Eggertsen G | title = Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns | journal = Genomics | volume = 56 | issue = 2 | pages = 184–96 |date=March 1999 | pmid = 10051404 | doi = 10.1006/geno.1998.5606 | url = | issn = }}</ref>


'''CYP8B1'''  ('''cy'''tochrome '''P'''450, family '''8''', subfamily '''B''', polypeptide '''1''') also known as''' sterol 12-alpha-hydroxylase''' is a [[protein]] which in humans is encoded by the ''CYP39A1'' [[gene]].<ref name="pmid10051404">{{cite journal | author = Gåfvels M, Olin M, Chowdhary BP, Raudsepp T, Andersson U, Persson B, Jansson M, Björkhem I, Eggertsen G | title = Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns | journal = Genomics | volume = 56 | issue = 2 | pages = 184–96 | year = 1999 | month = March | pmid = 10051404 | doi = 10.1006/geno.1998.5606 | url = | issn = }}</ref>
This gene encodes a member of the [[cytochrome P450]] superfamily of enzymes. The cytochrome P450 proteins are [[monooxygenase]]s which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.
This gene encodes a member of the [[cytochrome P450]] superfamily of enzymes. The cytochrome P450 proteins are [[monooxygenase]]s which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This [[endoplasmic reticulum]] membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of [[cholic acid]] and [[chenodeoxycholic acid]] both of which are secreted in the bile and affect the solubility of [[cholesterol]]. This gene is unique among the cytochrome P450 genes in that it is [[intron]]less.<ref name="entrez">{{cite web | title = Entrez Gene: CYP8B1 | url =http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1582 | accessdate = }}</ref>
 
CYP8B1 is an [[endoplasmic reticulum]] membrane protein and catalyzes the conversion of [[7 alpha-hydroxy-4-cholesten-3-one]] into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of the two primary [[bile acid]]s, [[cholic acid]] and [[chenodeoxycholic acid]], both of which are secreted in the bile.  In the intestine these [[bile acid]]s affect the solubility of [[cholesterol]] and other lipids, promoting their absorption.
 
''CYP8B1'' is unique among the cytochrome P450 genes in that it is [[intron]]less.<ref name="entrez">{{cite web | title = Entrez Gene: CYP8B1 | url =https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1582 | accessdate = }}</ref>


==References==
==References==
{{Reflist}}
{{Reflist}}
==Further reading==
{{refbegin | 2}}
*{{cite journal  |vauthors=Li Y, Mezei O, Shay NF |title=Human and murine hepatic sterol-12-alpha-hydroxylase and other xenobiotic metabolism mRNA are upregulated by soy isoflavones. |journal=J. Nutr. |volume=137 |issue= 7 |pages= 1705–12 |year= 2007 |pmid= 17585019 |doi=  }}
*{{cite journal  |vauthors=Yang Y, Eggertsen G, Gåffvels M |title=Mechanisms of cholesterol and sterol regulatory element binding protein regulation of the sterol 12alpha-hydroxylase gene (CYP8B1). |journal=Biochem. Biophys. Res. Commun. |volume=320 |issue= 4 |pages= 1204–10 |year= 2004 |pmid= 15249218 |doi= 10.1016/j.bbrc.2004.06.069 |display-authors=etal}}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  |pmc=528928 |display-authors=etal}}
*{{cite journal  |author=Ellis EC |title=Suppression of bile acid synthesis by thyroid hormone in primary human hepatocytes. |journal=World J. Gastroenterol. |volume=12 |issue= 29 |pages= 4640–5 |year= 2006 |pmid= 16937432 |doi=  }}
*{{cite journal  |vauthors=Wang J, Greene S, Eriksson LC |title=Human sterol 12a-hydroxylase (CYP8B1) is mainly expressed in hepatocytes in a homogenous pattern. |journal=Histochem. Cell Biol. |volume=123 |issue= 4-5 |pages= 441–6 |year= 2005 |pmid= 15891895 |doi= 10.1007/s00418-005-0779-0 |display-authors=etal}}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899  |pmc=139241 |display-authors=etal}}
*{{cite journal  |vauthors=Nelson DR, Zeldin DC, Hoffman SM |title=Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. |journal=Pharmacogenetics |volume=14 |issue= 1 |pages= 1–18 |year= 2004 |pmid= 15128046 |doi=10.1097/00008571-200401000-00001  |display-authors=etal}}
*{{cite journal  |vauthors=Ross CJ, Katzov-Eckert H, Dubé MP |title=Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. |journal=Nat. Genet. |volume=41 |issue= 12 |pages= 1345–9 |year= 2009 |pmid= 19898482 |doi= 10.1038/ng.478 |display-authors=etal}}
*{{cite journal  |vauthors=Lu Y, Dollé ME, Imholz S |title=Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. |journal=J. Lipid Res. |volume=49 |issue= 12 |pages= 2582–9 |year= 2008 |pmid= 18660489 |doi= 10.1194/jlr.M800232-JLR200 |display-authors=etal}}
*{{cite journal  |vauthors=Zhang M, Chiang JY |title=Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 41690–9 |year= 2001 |pmid= 11535594 |doi= 10.1074/jbc.M105117200 }}
{{refend}}


{{NLM content}}
{{NLM content}}
{{Cytochrome P450}}


{{Cytochrome P450}}


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Latest revision as of 10:16, 30 August 2017

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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Wikidata
View/Edit Human

CYP8B1 (cytochrome P450, family 8, subfamily B, polypeptide 1) also known as sterol 12-alpha-hydroxylase is a protein which in humans is encoded by the CYP8B1 gene.[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

CYP8B1 is an endoplasmic reticulum membrane protein and catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of the two primary bile acids, cholic acid and chenodeoxycholic acid, both of which are secreted in the bile. In the intestine these bile acids affect the solubility of cholesterol and other lipids, promoting their absorption.

CYP8B1 is unique among the cytochrome P450 genes in that it is intronless.[2]

References

  1. ↑ Gåfvels M, Olin M, Chowdhary BP, Raudsepp T, Andersson U, Persson B, Jansson M, Björkhem I, Eggertsen G (March 1999). "Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns". Genomics. 56 (2): 184–96. doi:10.1006/geno.1998.5606. PMID 10051404.
  2. ↑ "Entrez Gene: CYP8B1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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