CYP4B1

Cytochrome P450, family 4, subfamily B, polypeptide 1
Identifiers
Symbols	CYP4B1 ; P-450HP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 73900
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

WikiDoc Resources for CYP4B1
Articles
Most recent articles on CYP4B1 Most cited articles on CYP4B1 Review articles on CYP4B1 Articles on CYP4B1 in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on CYP4B1 Images of CYP4B1 Photos of CYP4B1 Podcasts & MP3s on CYP4B1 Videos on CYP4B1
Evidence Based Medicine
Cochrane Collaboration on CYP4B1 Bandolier on CYP4B1 TRIP on CYP4B1
Clinical Trials
Ongoing Trials on CYP4B1 at Clinical Trials.gov Trial results on CYP4B1 Clinical Trials on CYP4B1 at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on CYP4B1 NICE Guidance on CYP4B1 NHS PRODIGY Guidance FDA on CYP4B1 CDC on CYP4B1
Books
Books on CYP4B1
News
CYP4B1 in the news Be alerted to news on CYP4B1 News trends on CYP4B1
Commentary
Blogs on CYP4B1
Definitions
Definitions of CYP4B1
Patient Resources / Community
Patient resources on CYP4B1 Discussion groups on CYP4B1 Patient Handouts on CYP4B1 Directions to Hospitals Treating CYP4B1 Risk calculators and risk factors for CYP4B1
Healthcare Provider Resources
Symptoms of CYP4B1 Causes & Risk Factors for CYP4B1 Diagnostic studies for CYP4B1 Treatment of CYP4B1
Continuing Medical Education (CME)
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International
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Business
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Experimental / Informatics
List of terms related to CYP4B1

Cytochrome P450, family 4, subfamily B, polypeptide 1, also known as CYP4B1, is a human gene.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined.

Further reading

• Windmill KF, McKinnon RA, Zhu X; et al. (1997). "The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies". Mutat. Res. 376 (1–2): 153–60. PMID 9202751.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hakkola J, Pelkonen O, Pasanen M, Raunio H (1998). "Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: role in intrauterine toxicity". Crit. Rev. Toxicol. 28 (1): 35–72. PMID 9493761.CS1 maint: Multiple names: authors list (link)
• Yokotani N, Sogawa K, Matsubara S; et al. (1990). "cDNA cloning of cytochrome P-450 related to P-450p-2 from the cDNA library of human placenta. Gene structure and expression". Eur. J. Biochem. 187 (1): 23–9. PMID 2298205.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nhamburo PT, Gonzalez FJ, McBride OW; et al. (1990). "Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping". Biochemistry. 28 (20): 8060–6. PMID 2574990.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McKinnon RA, Burgess WM, Gonzalez FJ; et al. (1995). "Species-specific expression of CYP4B1 in rabbit and human gastrointestinal tissues". Pharmacogenetics. 4 (5): 260–70. PMID 7894498.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Czerwinski M, McLemore TL, Gelboin HV, Gonzalez FJ (1994). "Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors". Cancer Res. 54 (4): 1085–91. PMID 8313365.CS1 maint: Multiple names: authors list (link)
• Hakkola J, Raunio H, Purkunen R; et al. (1996). "Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy". Biochem. Pharmacol. 52 (2): 379–83. PMID 8694864.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Hukkanen J, Hakkola J, Anttila S; et al. (1997). "Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes". Mol. Carcinog. 20 (2): 224–30. PMID 9364212.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hukkanen J, Mäntylä M, Kangas L; et al. (1998). "Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium". Pharmacol. Toxicol. 82 (2): 93–7. PMID 9498238.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Thum T, Borlak J (2000). "Gene expression in distinct regions of the heart". Lancet. 355 (9208): 979–83. PMID 10768437.
• Imaoka S, Yoneda Y, Sugimoto T; et al. (2000). "CYP4B1 is a possible risk factor for bladder cancer in humans". Biochem. Biophys. Res. Commun. 277 (3): 776–80. doi:10.1006/bbrc.2000.3740. PMID 11062028.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Henne KR, Kunze KL, Zheng YM; et al. (2001). "Covalent linkage of prosthetic heme to CYP4 family P450 enzymes". Biochemistry. 40 (43): 12925–31. PMID 11669629.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Finnström N, Bjelfman C, Söderström TG; et al. (2002). "Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR". Eur. J. Clin. Invest. 31 (10): 880–6. PMID 11737226.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Iscan M, Klaavuniemi T, Coban T; et al. (2002). "The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue". Breast Cancer Res. Treat. 70 (1): 47–54. PMID 11767004.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lo-Guidice JM, Allorge D, Cauffiez C; et al. (2003). "Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant". Pharmacogenetics. 12 (5): 367–74. PMID 12142726.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)