CYFIP1

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Cytoplasmic FMR1-interacting protein 1 is a protein that in humans is encoded by the CYFIP1 gene.[1][2]


Interactions

CYFIP1 has been shown to interact with FMR1,[1] to the exclusion of FXR1 and FXR2.[1] It also forms part of the WAVE regulatory complex (WRC),[3] and based on the crystal structure of the WRC it is believed CYFIP1 provides the binding site for the complex to Rac1.[4]

References

  1. 1.0 1.1 1.2 Schenck A, Bardoni B, Moro A, Bagni C, Mandel JL (Jul 2001). "A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P". Proc Natl Acad Sci U S A. 98 (15): 8844–9. doi:10.1073/pnas.151231598. PMC 37523. PMID 11438699.
  2. "Entrez Gene: CYFIP1 cytoplasmic FMR1 interacting protein 1".
  3. Chen Z, Borek D, Padrick SB, Gomez TS, Metlagel Z, Ismail AM, Umetani J, Billadeau DD, Otwinowski Z, Rosen MK (25 Nov 2010). "Structure and control of the actin regulatory WAVE complex". Nature. 468 (7323): 533–8. doi:10.1038/nature09623. PMC 3085272. PMID 21107423.
  4. Koronakis V, Hume PJ, Humphreys D, Liu T, Hørning O, Jensen ON, McGhie EJ (30 Aug 2011). "WAVE regulatory complex activation by cooperating GTPases Arf and Rac1". Proc Natl Acad Sci U S A. 108 (35): 14449–54. doi:10.1073/pnas.1107666108. PMC 3167530. PMID 21844371.

Further reading

External links