CRKL: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Crk-like protein''' is a [[protein]] that in humans is encoded by the [[CRK (gene)|CRKL gene]].<ref name="pmid8361759">{{cite journal | vauthors = ten Hoeve J, Morris C, Heisterkamp N, Groffen J | title = Isolation and chromosomal localization of CRKL, a human crk-like gene | journal = Oncogene | volume = 8 | issue = 9 | pages = 2469–74 | date = September 1993 | pmid = 8361759 | pmc =  | doi =  }}</ref><ref name="pmid8798523">{{cite journal | vauthors = Senechal K, Halpern J, Sawyers CL | title = The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene | journal = The Journal of Biological Chemistry | volume = 271 | issue = 38 | pages = 23255–61 | date = September 1996 | pmid = 8798523 | pmc = | doi = 10.1074/jbc.271.38.23255 }}</ref>
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| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_CRKL_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2bzx.
| PDB = {{PDB2|2bzx}}, {{PDB2|2bzy}}, {{PDB2|2dbk}}
| Name = V-crk sarcoma virus CT10 oncogene homolog (avian)-like
| HGNCid = 2363
| Symbol = CRKL
| AltSymbols =;
| OMIM = 602007
| ECnumber = 
| Homologene = 38021
| MGIid = 104686
| GeneAtlas_image1 = PBB_GE_CRKL_212180_at_tn.png
| Function = {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007254 |text = JNK cascade}} {{GNF_GO|id=GO:0007265 |text = Ras protein signal transduction}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1399
    | Hs_Ensembl = ENSG00000099942
    | Hs_RefseqProtein = NP_005198
    | Hs_RefseqmRNA = NM_005207
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 19601722
    | Hs_GenLoc_end = 19638034
    | Hs_Uniprot = P46109
    | Mm_EntrezGene = 12929
    | Mm_Ensembl = ENSMUSG00000006134
    | Mm_RefseqmRNA = NM_007764
    | Mm_RefseqProtein = NP_031790
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 17365550
    | Mm_GenLoc_end = 17399818
    | Mm_Uniprot = Q8R5B8
  }}
}}
'''V-crk sarcoma virus CT10 oncogene homolog (avian)-like''', also known as '''CRKL''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains.  CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion.  It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL.  In addition, CRKL has oncogenic potential.<ref>{{cite web |title=Entrez Gene: CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like|url=https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1399|accessdate=}}</ref>
{{PBB_Summary
| section_title =
| summary_text = v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains.  CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion.  It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL.  In addition, CRKL has oncogenic potential.<ref>{{cite web | title = Entrez Gene: CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1399| accessdate = }}</ref>
}}


==References==
CrkL together with [[CRK (gene)|Crk]] participates in the [[Reelin]] signaling cascade downstream of [[DAB1]].<!--
{{reflist|2}}
 
==Further reading==
--><ref name="pmid18477607">{{cite journal | vauthors = Matsuki T, Pramatarova A, Howell BW | title = Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis | journal = Journal of Cell Science | volume = 121 | issue = 11 | pages = 1869–75 | date = June 2008 | pmid = 18477607 | pmc = 2430739 | doi = 10.1242/jcs.027334 | url = http://jcs.biologists.org/cgi/pmidlookup?view=long&pmid=18477607 }}</ref><ref name="pmid19074029">{{cite journal | vauthors = Park TJ, Curran T | title = Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway | journal = The Journal of Neuroscience | volume = 28 | issue = 50 | pages = 13551–62 | date = December 2008 | pmid = 19074029 | pmc = 2628718 | doi = 10.1523/JNEUROSCI.4323-08.2008 }}</ref>
{{refbegin | 2}}
 
{{PBB_Further_reading
== Interactions ==
| citations =  
 
*{{cite journal  | author=Feller SM, Posern G, Voss J, ''et al.'' |title=Physiological signals and oncogenesis mediated through Crk family adapter proteins. |journal=J. Cell. Physiol. |volume=177 |issue= 4 |pages= 535-52 |year= 1999 |pmid= 10092207 |doi= 10.1002/(SICI)1097-4652(199812)177:4<535::AID-JCP5>3.0.CO;2-E }}
CRKL has been shown to [[Protein-protein interaction|interact]] with:
*{{cite journal | author=Salgia R, Uemura N, Okuda K, ''et al.'' |title=CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells. |journal=J. Biol. Chem. |volume=270 |issue= 49 |pages= 29145-50 |year= 1996 |pmid= 7493940 |doi=  }}
{{div col|colwidth=20em}}
*{{cite journal | author=Ren R, Ye ZS, Baltimore D |title=Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites. |journal=Genes Dev. |volume=8 |issue= 7 |pages= 783-95 |year= 1994 |pmid= 7926767 |doi= }}
* [[Abl gene]],<ref name=pmid9820532/><ref name=pmid8978305>{{cite journal | vauthors = Heaney C, Kolibaba K, Bhat A, Oda T, Ohno S, Fanning S, Druker BJ | title = Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation | journal = Blood | volume = 89 | issue = 1 | pages = 297–306 | date = January 1997 | pmid = 8978305 | doi =  }}</ref><ref name=pmid7926767>{{cite journal | vauthors = Ren R, Ye ZS, Baltimore D | title = Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites | journal = Genes & Development | volume = 8 | issue = 7 | pages = 783–95 | date = April 1994 | pmid = 7926767 | doi = 10.1101/gad.8.7.783 }}</ref>
*{{cite journal | author=Oda T, Heaney C, Hagopian JR, ''et al.'' |title=Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia. |journal=J. Biol. Chem. |volume=269 |issue= 37 |pages= 22925-8 |year= 1994 |pmid= 8083188 |doi= }}
* [[BCAR1]],<ref name=pmid8810278>{{cite journal | vauthors = Salgia R, Pisick E, Sattler M, Li JL, Uemura N, Wong WK, Burky SA, Hirai H, Chen LB, Griffin JD | title = p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene | journal = The Journal of Biological Chemistry | volume = 271 | issue = 41 | pages = 25198–203 | date = October 1996 | pmid = 8810278 | doi = 10.1074/jbc.271.41.25198 }}</ref><ref name=pmid9498705>{{cite journal | vauthors = Astier A, Manié SN, Law SF, Canty T, Haghayghi N, Druker BJ, Salgia R, Golemis EA, Freedman AS | title = Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cells | journal = Leukemia & Lymphoma | volume = 28 | issue = 1-2 | pages = 65–72 | date = December 1997 | pmid = 9498705 | doi = 10.3109/10428199709058332 }}</ref>
*{{cite journal | author=ten Hoeve J, Morris C, Heisterkamp N, Groffen J |title=Isolation and chromosomal localization of CRKL, a human crk-like gene. |journal=Oncogene |volume=8 |issue= 9 |pages= 2469-74 |year= 1993 |pmid= 8361759 |doi= }}
* [[BCR gene]],<ref name=pmid8978305/><ref name=pmid9747873>{{cite journal | vauthors = Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J | title = The SH2-containing adapter protein GRB10 interacts with BCR-ABL | journal = Oncogene | volume = 17 | issue = 8 | pages = 941–8 | date = August 1998 | pmid = 9747873 | doi = 10.1038/sj.onc.1202024 }}</ref><ref name=pmid10194128>{{cite journal | vauthors = Kolibaba KS, Bhat A, Heaney C, Oda T, Druker BJ | title = CRKL binding to BCR-ABL and BCR-ABL transformation | journal = Leukemia & Lymphoma | volume = 33 | issue = 1-2 | pages = 119–26 | date = March 1999 | pmid = 10194128 | doi = 10.3109/10428199909093732 }}</ref><ref name=pmid15143164>{{cite journal | vauthors = Million RP, Harakawa N, Roumiantsev S, Varticovski L, Van Etten RA | title = A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase | journal = Molecular and Cellular Biology | volume = 24 | issue = 11 | pages = 4685–95 | date = June 2004 | pmid = 15143164 | pmc = 416425 | doi = 10.1128/MCB.24.11.4685-4695.2004 }}</ref>
*{{cite journal  | author=Smit L, van der Horst G, Borst J |title=Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors. |journal=J. Biol. Chem. |volume=271 |issue= 15 |pages= 8564-9 |year= 1996 |pmid= 8621483 |doi= }}
* [[CBLB (genetics)|CBLB]],<ref name=pmid10022120>{{cite journal | vauthors = Elly C, Witte S, Zhang Z, Rosnet O, Lipkowitz S, Altman A, Liu YC | title = Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation | journal = Oncogene | volume = 18 | issue = 5 | pages = 1147–56 | date = February 1999 | pmid = 10022120 | doi = 10.1038/sj.onc.1202411 }}</ref>
*{{cite journal | author=Senechal K, Halpern J, Sawyers CL |title=The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene. |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 23255-61 |year= 1996 |pmid= 8798523 |doi= }}
* [[CD117]],<ref name=pmid11071635>{{cite journal | vauthors = van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M | title = Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells | journal = Blood | volume = 96 | issue = 10 | pages = 3406–13 | date = November 2000 | pmid = 11071635 | doi =  }}</ref><ref name=pmid9092574>{{cite journal | vauthors = Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD | title = Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL) | journal = The Journal of Biological Chemistry | volume = 272 | issue = 15 | pages = 10248–53 | date = April 1997 | pmid = 9092574 | doi = 10.1074/jbc.272.15.10248 }}</ref>
*{{cite journal | author=Salgia R, Pisick E, Sattler M, ''et al.'' |title=p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene. |journal=J. Biol. Chem. |volume=271 |issue= 41 |pages= 25198-203 |year= 1996 |pmid= 8810278 |doi= }}
* [[CD34]],<ref name=pmid11389015>{{cite journal | vauthors = Felschow DM, McVeigh ML, Hoehn GT, Civin CI, Fackler MJ | title = The adapter protein CrkL associates with CD34 | journal = Blood | volume = 97 | issue = 12 | pages = 3768–75 | date = June 2001 | pmid = 11389015 | doi = 10.1182/blood.v97.12.3768 }}</ref>
*{{cite journal | author=Ingham RJ, Krebs DL, Barbazuk SM, ''et al.'' |title=B cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteins. |journal=J. Biol. Chem. |volume=271 |issue= 50 |pages= 32306-14 |year= 1997 |pmid= 8943292 |doi= }}
* [[Cbl gene]],<ref name=pmid9820532/><ref name=pmid9092574/><ref name=pmid9344843/><ref name=pmid10907644>{{cite journal | vauthors = Alsayed Y, Modi S, Uddin S, Mahmud N, Druker BJ, Fish EN, Hoffman R, Platanias LC | title = All-trans-retinoic acid induces tyrosine phosphorylation of the CrkL adapter in acute promyelocytic leukemia cells | journal = Experimental Hematology | volume = 28 | issue = 7 | pages = 826–32 | date = July 2000 | pmid = 10907644 | doi = 10.1016/s0301-472x(00)00170-3 }}</ref><ref name=pmid11133830>{{cite journal | vauthors = Lin H, Martelli MP, Bierer BE | title = The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation | journal = International Immunology | volume = 13 | issue = 1 | pages = 13–22 | date = January 2001 | pmid = 11133830 | doi = 10.1093/intimm/13.1.13 }}</ref><ref name=pmid9590251>{{cite journal | vauthors = Park RK, Kyono WT, Liu Y, Durden DL | title = CBL-GRB2 interaction in myeloid immunoreceptor tyrosine activation motif signaling | journal = Journal of Immunology | volume = 160 | issue = 10 | pages = 5018–27 | date = May 1998 | pmid = 9590251 | doi =  }}</ref><ref name=pmid12244174>{{cite journal | vauthors = Taher TE, Tjin EP, Beuling EA, Borst J, Spaargaren M, Pals ST | title = c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination | journal = Journal of Immunology | volume = 169 | issue = 7 | pages = 3793–800 | date = October 2002 | pmid = 12244174 | doi = 10.4049/jimmunol.169.7.3793 }}</ref><ref name=pmid10204582>{{cite journal | vauthors = Erdreich-Epstein A, Liu M, Kant AM, Izadi KD, Nolta JA, Durden DL | title = Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages | journal = Journal of Leukocyte Biology | volume = 65 | issue = 4 | pages = 523–34 | date = April 1999 | pmid = 10204582 | doi = }}</ref><ref name=pmid9162067>{{cite journal | vauthors = Sattler M, Salgia R, Shrikhande G, Verma S, Uemura N, Law SF, Golemis EA, Griffin JD | title = Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1) | journal = The Journal of Biological Chemistry | volume = 272 | issue = 22 | pages = 14320–6 | date = May 1997 | pmid = 9162067 | doi = 10.1074/jbc.272.22.14320 }}</ref><ref name=pmid9461587>{{cite journal | vauthors = Gesbert F, Garbay C, Bertoglio J | title = Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells | journal = The Journal of Biological Chemistry | volume = 273 | issue = 7 | pages = 3986–93 | date = February 1998 | pmid = 9461587 | doi = 10.1074/jbc.273.7.3986 }}</ref>
*{{cite journal | author=Heaney C, Kolibaba K, Bhat A, ''et al.'' |title=Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation. |journal=Blood |volume=89 |issue= 1 |pages= 297-306 |year= 1997 |pmid= 8978305 |doi=  }}
* [[Dock2]],<ref name=pmid12393632>{{cite journal | vauthors = Nishihara H, Maeda M, Oda A, Tsuda M, Sawa H, Nagashima K, Tanaka S | title = DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines | journal = Blood | volume = 100 | issue = 12 | pages = 3968–74 | date = December 2002 | pmid = 12393632 | doi = 10.1182/blood-2001-11-0032 }}</ref>
*{{cite journal | author=Manié SN, Beck AR, Astier A, ''et al.'' |title=Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells. |journal=J. Biol. Chem. |volume=272 |issue= 7 |pages= 4230-6 |year= 1997 |pmid= 9020138 |doi= }}
* [[Erythropoietin receptor|EPOR]],<ref name=pmid9344843/><ref name=pmid11443118>{{cite journal | vauthors = Arai A, Kanda E, Nosaka Y, Miyasaka N, Miura O | title = CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling | journal = The Journal of Biological Chemistry | volume = 276 | issue = 35 | pages = 33282–90 | date = August 2001 | pmid = 11443118 | doi = 10.1074/jbc.M102924200 }}</ref>
*{{cite journal | author=de Jong R, ten Hoeve J, Heisterkamp N, Groffen J |title=Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site. |journal=Oncogene |volume=14 |issue= 5 |pages= 507-13 |year= 1997 |pmid= 9053848 |doi= 10.1038/sj.onc.1200885 }}
* [[GAB1]],<ref name=pmid10753869/>
*{{cite journal | author=Uemura N, Salgia R, Li JL, ''et al.'' |title=The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins. |journal=Leukemia |volume=11 |issue= 3 |pages= 376-85 |year= 1997 |pmid= 9067577 |doi= }}
* [[GAB2]],<ref name=pmid11334882>{{cite journal | vauthors = Crouin C, Arnaud M, Gesbert F, Camonis J, Bertoglio J | title = A yeast two-hybrid study of human p97/Gab2 interactions with its SH2 domain-containing binding partners | journal = FEBS Letters | volume = 495 | issue = 3 | pages = 148–53 | date = April 2001 | pmid = 11334882 | doi = 10.1016/s0014-5793(01)02373-0 }}</ref>
*{{cite journal | author=Sattler M, Salgia R, Shrikhande G, ''et al.'' |title=Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL). |journal=J. Biol. Chem. |volume=272 |issue= 15 |pages= 10248-53 |year= 1997 |pmid= 9092574 |doi= }}
* [[INPP5D]],<ref name=pmid11443118/>
*{{cite journal | author=Sattler M, Salgia R, Shrikhande G, ''et al.'' |title=Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1). |journal=J. Biol. Chem. |volume=272 |issue= 22 |pages= 14320-6 |year= 1997 |pmid= 9162067 |doi=  }}
* [[MAP4K1]],<ref name=pmid9788432>{{cite journal | vauthors = Oehrl W, Kardinal C, Ruf S, Adermann K, Groffen J, Feng GS, Blenis J, Tan TH, Feller SM | title = The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins | journal = Oncogene | volume = 17 | issue = 15 | pages = 1893–901 | date = October 1998 | pmid = 9788432 | doi = 10.1038/sj.onc.1202108 }}</ref><ref name=pmid9891069>{{cite journal | vauthors = Ling P, Yao Z, Meyer CF, Wang XS, Oehrl W, Feller SM, Tan TH | title = Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase | journal = Molecular and Cellular Biology | volume = 19 | issue = 2 | pages = 1359–68 | date = February 1999 | pmid = 9891069 | pmc = 116064 | doi =  }}</ref><ref name=pmid11279207>{{cite journal | vauthors = Ling P, Meyer CF, Redmond LP, Shui JW, Davis B, Rich RR, Hu MC, Wange RL, Tan TH | title = Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling | journal = The Journal of Biological Chemistry | volume = 276 | issue = 22 | pages = 18908–14 | date = June 2001 | pmid = 11279207 | doi = 10.1074/jbc.M101485200 }}</ref>
*{{cite journal | author=Husson H, Mograbi B, Schmid-Antomarchi H, ''et al.'' |title=CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2. |journal=Oncogene |volume=14 |issue= 19 |pages= 2331-8 |year= 1997 |pmid= 9178909 |doi= 10.1038/sj.onc.1201074 }}
* [[MAP4K5]],<ref name=pmid10648385>{{cite journal | vauthors = Shi CS, Tuscano J, Kehrl JH | title = Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation | journal = Blood | volume = 95 | issue = 3 | pages = 776–82 | date = February 2000 | pmid = 10648385 | doi =  }}</ref>
*{{cite journal | author=Chin H, Saito T, Arai A, ''et al.'' |title=Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells. |journal=Biochem. Biophys. Res. Commun. |volume=239 |issue= 2 |pages= 412-7 |year= 1997 |pmid= 9344843 |doi= 10.1006/bbrc.1997.7480 }}
* [[NEDD9]],<ref name=pmid9820532/><ref name=pmid9498705/><ref name=pmid9162067/><ref name=pmid9020138>{{cite journal | vauthors = Manié SN, Beck AR, Astier A, Law SF, Canty T, Hirai H, Druker BJ, Avraham H, Haghayeghi N, Sattler M, Salgia R, Griffin JD, Golemis EA, Freedman AS | title = Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells | journal = The Journal of Biological Chemistry | volume = 272 | issue = 7 | pages = 4230–6 | date = February 1997 | pmid = 9020138 | doi = 10.1074/jbc.272.7.4230 }}</ref>
*{{cite journal | author=Ahmad S, Alsayed YM, Druker BJ, Platanias LC |title=The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein. |journal=J. Biol. Chem. |volume=272 |issue= 48 |pages= 29991-4 |year= 1997 |pmid= 9374471 |doi= }}
* [[PIK3R2]],<ref name=pmid9092574/>
*{{cite journal | author=de Jong R, van Wijk A, Haataja L, ''et al.'' |title=BCR/ABL-induced leukemogenesis causes phosphorylation of Hef1 and its association with Crkl. |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 32649-55 |year= 1998 |pmid= 9405482 |doi= }}
* [[Paxillin]]<ref name=pmid7493940>{{cite journal | vauthors = Salgia R, Uemura N, Okuda K, Li JL, Pisick E, Sattler M, de Jong R, Druker B, Heisterkamp N, Chen LB | title = CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells | journal = The Journal of Biological Chemistry | volume = 270 | issue = 49 | pages = 29145–50 | date = December 1995 | pmid = 7493940 | doi = 10.1074/jbc.270.49.29145 }}</ref><ref name=pmid11463817>{{cite journal | vauthors = Nishiya N, Tachibana K, Shibanuma M, Mashimo JI, Nose K | title = Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase | journal = Molecular and Cellular Biology | volume = 21 | issue = 16 | pages = 5332–45 | date = August 2001 | pmid = 11463817 | pmc = 87257 | doi = 10.1128/MCB.21.16.5332-5345.2001 }}</ref>
*{{cite journal  | author=Gesbert F, Garbay C, Bertoglio J |title=Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells. |journal=J. Biol. Chem. |volume=273 |issue= 7 |pages= 3986-93 |year= 1998 |pmid= 9461587 |doi= }}
* [[RAPGEF1]],<ref name=pmid9820532>{{cite journal | vauthors = Kyono WT, de Jong R, Park RK, Liu Y, Heisterkamp N, Groffen J, Durden DL | title = Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI) | journal = Journal of Immunology | volume = 161 | issue = 10 | pages = 5555–63 | date = November 1998 | pmid = 9820532 | doi =  }}</ref><ref name=pmid9344843>{{cite journal | vauthors = Chin H, Saito T, Arai A, Yamamoto K, Kamiyama R, Miyasaka N, Miura O | title = Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells | journal = Biochemical and Biophysical Research Communications | volume = 239 | issue = 2 | pages = 412–7 | date = October 1997 | pmid = 9344843 | doi = 10.1006/bbrc.1997.7480 }}</ref><ref name=pmid10753869>{{cite journal | vauthors = Sakkab D, Lewitzky M, Posern G, Schaeper U, Sachs M, Birchmeier W, Feller SM | title = Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL | journal = The Journal of Biological Chemistry | volume = 275 | issue = 15 | pages = 10772–8 | date = April 2000 | pmid = 10753869 | doi = 10.1074/jbc.275.15.10772 }}</ref><ref name=pmid11167825>{{cite journal | vauthors = Grumbach IM, Mayer IA, Uddin S, Lekmine F, Majchrzak B, Yamauchi H, Fujita S, Druker B, Fish EN, Platanias LC | title = Engagement of the CrkL adaptor in interferon alpha signalling in BCR-ABL-expressing cells | journal = British Journal of Haematology | volume = 112 | issue = 2 | pages = 327–36 | date = February 2001 | pmid = 11167825 | doi = 10.1046/j.1365-2141.2001.02556.x }}</ref><ref name=pmid9374471>{{cite journal | vauthors = Ahmad S, Alsayed YM, Druker BJ, Platanias LC | title = The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein | journal = The Journal of Biological Chemistry | volume = 272 | issue = 48 | pages = 29991–4 | date = November 1997 | pmid = 9374471 | doi = 10.1074/jbc.272.48.29991 }}</ref><ref name=pmid8621483>{{cite journal | vauthors = Smit L, van der Horst G, Borst J | title = Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors | journal = The Journal of Biological Chemistry | volume = 271 | issue = 15 | pages = 8564–9 | date = April 1996 | pmid = 8621483 | doi = 10.1074/jbc.271.15.8564 }}</ref><ref name=pmid11466412>{{cite journal | vauthors = Wu C, Lai CF, Mobley WC | title = Nerve growth factor activates persistent Rap1 signaling in endosomes | journal = The Journal of Neuroscience | volume = 21 | issue = 15 | pages = 5406–16 | date = August 2001 | pmid = 11466412 | doi =  }}</ref>
}}
* [[RICS (gene)|RICS]],<ref name=pmid12446789>{{cite journal | vauthors = Nakamura T, Komiya M, Sone K, Hirose E, Gotoh N, Morii H, Ohta Y, Mori N | title = Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules | journal = Molecular and Cellular Biology | volume = 22 | issue = 24 | pages = 8721–34 | date = December 2002 | pmid = 12446789 | pmc = 139861 | doi = 10.1128/mcb.22.24.8721-8734.2002 }}</ref>
* [[STAT5A]],<ref name=pmid9837784>{{cite journal | vauthors = Ota J, Kimura F, Sato K, Wakimoto N, Nakamura Y, Nagata N, Suzu S, Yamada M, Shimamura S, Motoyoshi K | title = Association of CrkL with STAT5 in hematopoietic cells stimulated by granulocyte-macrophage colony-stimulating factor or erythropoietin | journal = Biochemical and Biophysical Research Communications | volume = 252 | issue = 3 | pages = 779–86 | date = November 1998 | pmid = 9837784 | doi = 10.1006/bbrc.1998.9445 }}</ref>
* [[Syk]],<ref name=pmid11313252>{{cite journal | vauthors = Oda A, Ochs HD, Lasky LA, Spencer S, Ozaki K, Fujihara M, Handa M, Ikebuchi K, Ikeda H | title = CrkL is an adapter for Wiskott-Aldrich syndrome protein and Syk | journal = Blood | volume = 97 | issue = 9 | pages = 2633–9 | date = May 2001 | pmid = 11313252 | doi = 10.1182/blood.v97.9.2633 }}</ref>  and
* [[Wiskott-Aldrich syndrome protein|WAS]].<ref name=pmid11313252/>
{{Div col end}}
 
{{Div col end}}
 
== See also ==
*[[CRK (gene)|Crk]]
{{Clear}}
 
== References ==
{{reflist}}
== Further reading ==
{{refbegin|35em}}
* {{cite journal | vauthors = Feller SM, Posern G, Voss J, Kardinal C, Sakkab D, Zheng J, Knudsen BS | title = Physiological signals and oncogenesis mediated through Crk family adapter proteins | journal = Journal of Cellular Physiology | volume = 177 | issue = 4 | pages = 535–52 | date = December 1998 | pmid = 10092207 | doi = 10.1002/(SICI)1097-4652(199812)177:4<535::AID-JCP5>3.0.CO;2-E }}
* {{cite journal | vauthors = Salgia R, Uemura N, Okuda K, Li JL, Pisick E, Sattler M, de Jong R, Druker B, Heisterkamp N, Chen LB | title = CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells | journal = The Journal of Biological Chemistry | volume = 270 | issue = 49 | pages = 29145–50 | date = December 1995 | pmid = 7493940 | doi = 10.1074/jbc.270.49.29145 }}
* {{cite journal | vauthors = Ren R, Ye ZS, Baltimore D | title = Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites | journal = Genes & Development | volume = 8 | issue = 7 | pages = 783–95 | date = April 1994 | pmid = 7926767 | doi = 10.1101/gad.8.7.783 }}
* {{cite journal | vauthors = Oda T, Heaney C, Hagopian JR, Okuda K, Griffin JD, Druker BJ | title = Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia | journal = The Journal of Biological Chemistry | volume = 269 | issue = 37 | pages = 22925–8 | date = September 1994 | pmid = 8083188 | doi =  }}
* {{cite journal | vauthors = Smit L, van der Horst G, Borst J | title = Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors | journal = The Journal of Biological Chemistry | volume = 271 | issue = 15 | pages = 8564–9 | date = April 1996 | pmid = 8621483 | doi = 10.1074/jbc.271.15.8564 }}
* {{cite journal | vauthors = Salgia R, Pisick E, Sattler M, Li JL, Uemura N, Wong WK, Burky SA, Hirai H, Chen LB, Griffin JD | title = p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene | journal = The Journal of Biological Chemistry | volume = 271 | issue = 41 | pages = 25198–203 | date = October 1996 | pmid = 8810278 | doi = 10.1074/jbc.271.41.25198 }}
* {{cite journal | vauthors = Ingham RJ, Krebs DL, Barbazuk SM, Turck CW, Hirai H, Matsuda M, Gold MR | title = B cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteins | journal = The Journal of Biological Chemistry | volume = 271 | issue = 50 | pages = 32306–14 | date = December 1996 | pmid = 8943292 | doi = 10.1074/jbc.271.50.32306 }}
* {{cite journal | vauthors = Heaney C, Kolibaba K, Bhat A, Oda T, Ohno S, Fanning S, Druker BJ | title = Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation | journal = Blood | volume = 89 | issue = 1 | pages = 297–306 | date = January 1997 | pmid = 8978305 | doi =  }}
* {{cite journal | vauthors = Manié SN, Beck AR, Astier A, Law SF, Canty T, Hirai H, Druker BJ, Avraham H, Haghayeghi N, Sattler M, Salgia R, Griffin JD, Golemis EA, Freedman AS | title = Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells | journal = The Journal of Biological Chemistry | volume = 272 | issue = 7 | pages = 4230–6 | date = February 1997 | pmid = 9020138 | doi = 10.1074/jbc.272.7.4230 }}
* {{cite journal | vauthors = de Jong R, ten Hoeve J, Heisterkamp N, Groffen J | title = Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site | journal = Oncogene | volume = 14 | issue = 5 | pages = 507–13 | date = February 1997 | pmid = 9053848 | doi = 10.1038/sj.onc.1200885 }}
* {{cite journal | vauthors = Uemura N, Salgia R, Li JL, Pisick E, Sattler M, Griffin JD | title = The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins | journal = Leukemia | volume = 11 | issue = 3 | pages = 376–85 | date = March 1997 | pmid = 9067577 | doi = 10.1038/sj.leu.2400590 }}
* {{cite journal | vauthors = Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD | title = Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL) | journal = The Journal of Biological Chemistry | volume = 272 | issue = 15 | pages = 10248–53 | date = April 1997 | pmid = 9092574 | doi = 10.1074/jbc.272.15.10248 }}
* {{cite journal | vauthors = Sattler M, Salgia R, Shrikhande G, Verma S, Uemura N, Law SF, Golemis EA, Griffin JD | title = Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1) | journal = The Journal of Biological Chemistry | volume = 272 | issue = 22 | pages = 14320–6 | date = May 1997 | pmid = 9162067 | doi = 10.1074/jbc.272.22.14320 }}
* {{cite journal | vauthors = Husson H, Mograbi B, Schmid-Antomarchi H, Fischer S, Rossi B | title = CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2 | journal = Oncogene | volume = 14 | issue = 19 | pages = 2331–8 | date = May 1997 | pmid = 9178909 | doi = 10.1038/sj.onc.1201074 }}
* {{cite journal | vauthors = Chin H, Saito T, Arai A, Yamamoto K, Kamiyama R, Miyasaka N, Miura O | title = Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells | journal = Biochemical and Biophysical Research Communications | volume = 239 | issue = 2 | pages = 412–7 | date = October 1997 | pmid = 9344843 | doi = 10.1006/bbrc.1997.7480 }}
* {{cite journal | vauthors = Ahmad S, Alsayed YM, Druker BJ, Platanias LC | title = The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein | journal = The Journal of Biological Chemistry | volume = 272 | issue = 48 | pages = 29991–4 | date = November 1997 | pmid = 9374471 | doi = 10.1074/jbc.272.48.29991 }}
* {{cite journal | vauthors = de Jong R, van Wijk A, Haataja L, Heisterkamp N, Groffen J | title = BCR/ABL-induced leukemogenesis causes phosphorylation of Hef1 and its association with Crkl | journal = The Journal of Biological Chemistry | volume = 272 | issue = 51 | pages = 32649–55 | date = December 1997 | pmid = 9405482 | doi = 10.1074/jbc.272.51.32649 }}
* {{cite journal | vauthors = Gesbert F, Garbay C, Bertoglio J | title = Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells | journal = The Journal of Biological Chemistry | volume = 273 | issue = 7 | pages = 3986–93 | date = February 1998 | pmid = 9461587 | doi = 10.1074/jbc.273.7.3986 }}
{{refend}}
{{refend}}
 
== External links ==
{{gene-22-stub}}
* {{UCSC gene info|CRKL}}
{{WikiDoc Sources}}
{{PDB Gallery|geneid=1399}}

Latest revision as of 21:01, 18 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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View/Edit Human

Crk-like protein is a protein that in humans is encoded by the CRKL gene.[1][2]

Function

v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential.[3]

CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1.[4][5]

Interactions

CRKL has been shown to interact with:

See also

References

  1. ↑ ten Hoeve J, Morris C, Heisterkamp N, Groffen J (September 1993). "Isolation and chromosomal localization of CRKL, a human crk-like gene". Oncogene. 8 (9): 2469–74. PMID 8361759.
  2. ↑ Senechal K, Halpern J, Sawyers CL (September 1996). "The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene". The Journal of Biological Chemistry. 271 (38): 23255–61. doi:10.1074/jbc.271.38.23255. PMID 8798523.
  3. ↑ "Entrez Gene: CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like".
  4. ↑ Matsuki T, Pramatarova A, Howell BW (June 2008). "Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis". Journal of Cell Science. 121 (11): 1869–75. doi:10.1242/jcs.027334. PMC 2430739. PMID 18477607.
  5. ↑ Park TJ, Curran T (December 2008). "Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway". The Journal of Neuroscience. 28 (50): 13551–62. doi:10.1523/JNEUROSCI.4323-08.2008. PMC 2628718. PMID 19074029.
  6. ↑ 6.0 6.1 6.2 6.3 Kyono WT, de Jong R, Park RK, Liu Y, Heisterkamp N, Groffen J, Durden DL (November 1998). "Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI)". Journal of Immunology. 161 (10): 5555–63. PMID 9820532.
  7. ↑ 7.0 7.1 Heaney C, Kolibaba K, Bhat A, Oda T, Ohno S, Fanning S, Druker BJ (January 1997). "Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation". Blood. 89 (1): 297–306. PMID 8978305.
  8. ↑ Ren R, Ye ZS, Baltimore D (April 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites". Genes & Development. 8 (7): 783–95. doi:10.1101/gad.8.7.783. PMID 7926767.
  9. ↑ Salgia R, Pisick E, Sattler M, Li JL, Uemura N, Wong WK, Burky SA, Hirai H, Chen LB, Griffin JD (October 1996). "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". The Journal of Biological Chemistry. 271 (41): 25198–203. doi:10.1074/jbc.271.41.25198. PMID 8810278.
  10. ↑ 10.0 10.1 Astier A, Manié SN, Law SF, Canty T, Haghayghi N, Druker BJ, Salgia R, Golemis EA, Freedman AS (December 1997). "Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cells". Leukemia & Lymphoma. 28 (1–2): 65–72. doi:10.3109/10428199709058332. PMID 9498705.
  11. ↑ Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J (August 1998). "The SH2-containing adapter protein GRB10 interacts with BCR-ABL". Oncogene. 17 (8): 941–8. doi:10.1038/sj.onc.1202024. PMID 9747873.
  12. ↑ Kolibaba KS, Bhat A, Heaney C, Oda T, Druker BJ (March 1999). "CRKL binding to BCR-ABL and BCR-ABL transformation". Leukemia & Lymphoma. 33 (1–2): 119–26. doi:10.3109/10428199909093732. PMID 10194128.
  13. ↑ Million RP, Harakawa N, Roumiantsev S, Varticovski L, Van Etten RA (June 2004). "A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase". Molecular and Cellular Biology. 24 (11): 4685–95. doi:10.1128/MCB.24.11.4685-4695.2004. PMC 416425. PMID 15143164.
  14. ↑ Elly C, Witte S, Zhang Z, Rosnet O, Lipkowitz S, Altman A, Liu YC (February 1999). "Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation". Oncogene. 18 (5): 1147–56. doi:10.1038/sj.onc.1202411. PMID 10022120.
  15. ↑ van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M (November 2000). "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells". Blood. 96 (10): 3406–13. PMID 11071635.
  16. ↑ 16.0 16.1 16.2 Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". The Journal of Biological Chemistry. 272 (15): 10248–53. doi:10.1074/jbc.272.15.10248. PMID 9092574.
  17. ↑ Felschow DM, McVeigh ML, Hoehn GT, Civin CI, Fackler MJ (June 2001). "The adapter protein CrkL associates with CD34". Blood. 97 (12): 3768–75. doi:10.1182/blood.v97.12.3768. PMID 11389015.
  18. ↑ 18.0 18.1 18.2 Chin H, Saito T, Arai A, Yamamoto K, Kamiyama R, Miyasaka N, Miura O (October 1997). "Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells". Biochemical and Biophysical Research Communications. 239 (2): 412–7. doi:10.1006/bbrc.1997.7480. PMID 9344843.
  19. ↑ Alsayed Y, Modi S, Uddin S, Mahmud N, Druker BJ, Fish EN, Hoffman R, Platanias LC (July 2000). "All-trans-retinoic acid induces tyrosine phosphorylation of the CrkL adapter in acute promyelocytic leukemia cells". Experimental Hematology. 28 (7): 826–32. doi:10.1016/s0301-472x(00)00170-3. PMID 10907644.
  20. ↑ Lin H, Martelli MP, Bierer BE (January 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation". International Immunology. 13 (1): 13–22. doi:10.1093/intimm/13.1.13. PMID 11133830.
  21. ↑ Park RK, Kyono WT, Liu Y, Durden DL (May 1998). "CBL-GRB2 interaction in myeloid immunoreceptor tyrosine activation motif signaling". Journal of Immunology. 160 (10): 5018–27. PMID 9590251.
  22. ↑ Taher TE, Tjin EP, Beuling EA, Borst J, Spaargaren M, Pals ST (October 2002). "c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination". Journal of Immunology. 169 (7): 3793–800. doi:10.4049/jimmunol.169.7.3793. PMID 12244174.
  23. ↑ Erdreich-Epstein A, Liu M, Kant AM, Izadi KD, Nolta JA, Durden DL (April 1999). "Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages". Journal of Leukocyte Biology. 65 (4): 523–34. PMID 10204582.
  24. ↑ 24.0 24.1 Sattler M, Salgia R, Shrikhande G, Verma S, Uemura N, Law SF, Golemis EA, Griffin JD (May 1997). "Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1)". The Journal of Biological Chemistry. 272 (22): 14320–6. doi:10.1074/jbc.272.22.14320. PMID 9162067.
  25. ↑ Gesbert F, Garbay C, Bertoglio J (February 1998). "Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells". The Journal of Biological Chemistry. 273 (7): 3986–93. doi:10.1074/jbc.273.7.3986. PMID 9461587.
  26. ↑ Nishihara H, Maeda M, Oda A, Tsuda M, Sawa H, Nagashima K, Tanaka S (December 2002). "DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines". Blood. 100 (12): 3968–74. doi:10.1182/blood-2001-11-0032. PMID 12393632.
  27. ↑ 27.0 27.1 Arai A, Kanda E, Nosaka Y, Miyasaka N, Miura O (August 2001). "CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling". The Journal of Biological Chemistry. 276 (35): 33282–90. doi:10.1074/jbc.M102924200. PMID 11443118.
  28. ↑ 28.0 28.1 Sakkab D, Lewitzky M, Posern G, Schaeper U, Sachs M, Birchmeier W, Feller SM (April 2000). "Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL". The Journal of Biological Chemistry. 275 (15): 10772–8. doi:10.1074/jbc.275.15.10772. PMID 10753869.
  29. ↑ Crouin C, Arnaud M, Gesbert F, Camonis J, Bertoglio J (April 2001). "A yeast two-hybrid study of human p97/Gab2 interactions with its SH2 domain-containing binding partners". FEBS Letters. 495 (3): 148–53. doi:10.1016/s0014-5793(01)02373-0. PMID 11334882.
  30. ↑ Oehrl W, Kardinal C, Ruf S, Adermann K, Groffen J, Feng GS, Blenis J, Tan TH, Feller SM (October 1998). "The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". Oncogene. 17 (15): 1893–901. doi:10.1038/sj.onc.1202108. PMID 9788432.
  31. ↑ Ling P, Yao Z, Meyer CF, Wang XS, Oehrl W, Feller SM, Tan TH (February 1999). "Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase". Molecular and Cellular Biology. 19 (2): 1359–68. PMC 116064. PMID 9891069.
  32. ↑ Ling P, Meyer CF, Redmond LP, Shui JW, Davis B, Rich RR, Hu MC, Wange RL, Tan TH (June 2001). "Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling". The Journal of Biological Chemistry. 276 (22): 18908–14. doi:10.1074/jbc.M101485200. PMID 11279207.
  33. ↑ Shi CS, Tuscano J, Kehrl JH (February 2000). "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation". Blood. 95 (3): 776–82. PMID 10648385.
  34. ↑ Manié SN, Beck AR, Astier A, Law SF, Canty T, Hirai H, Druker BJ, Avraham H, Haghayeghi N, Sattler M, Salgia R, Griffin JD, Golemis EA, Freedman AS (February 1997). "Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells". The Journal of Biological Chemistry. 272 (7): 4230–6. doi:10.1074/jbc.272.7.4230. PMID 9020138.
  35. ↑ Salgia R, Uemura N, Okuda K, Li JL, Pisick E, Sattler M, de Jong R, Druker B, Heisterkamp N, Chen LB (December 1995). "CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells". The Journal of Biological Chemistry. 270 (49): 29145–50. doi:10.1074/jbc.270.49.29145. PMID 7493940.
  36. ↑ Nishiya N, Tachibana K, Shibanuma M, Mashimo JI, Nose K (August 2001). "Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase". Molecular and Cellular Biology. 21 (16): 5332–45. doi:10.1128/MCB.21.16.5332-5345.2001. PMC 87257. PMID 11463817.
  37. ↑ Grumbach IM, Mayer IA, Uddin S, Lekmine F, Majchrzak B, Yamauchi H, Fujita S, Druker B, Fish EN, Platanias LC (February 2001). "Engagement of the CrkL adaptor in interferon alpha signalling in BCR-ABL-expressing cells". British Journal of Haematology. 112 (2): 327–36. doi:10.1046/j.1365-2141.2001.02556.x. PMID 11167825.
  38. ↑ Ahmad S, Alsayed YM, Druker BJ, Platanias LC (November 1997). "The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein". The Journal of Biological Chemistry. 272 (48): 29991–4. doi:10.1074/jbc.272.48.29991. PMID 9374471.
  39. ↑ Smit L, van der Horst G, Borst J (April 1996). "Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors". The Journal of Biological Chemistry. 271 (15): 8564–9. doi:10.1074/jbc.271.15.8564. PMID 8621483.
  40. ↑ Wu C, Lai CF, Mobley WC (August 2001). "Nerve growth factor activates persistent Rap1 signaling in endosomes". The Journal of Neuroscience. 21 (15): 5406–16. PMID 11466412.
  41. ↑ Nakamura T, Komiya M, Sone K, Hirose E, Gotoh N, Morii H, Ohta Y, Mori N (December 2002). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Molecular and Cellular Biology. 22 (24): 8721–34. doi:10.1128/mcb.22.24.8721-8734.2002. PMC 139861. PMID 12446789.
  42. ↑ Ota J, Kimura F, Sato K, Wakimoto N, Nakamura Y, Nagata N, Suzu S, Yamada M, Shimamura S, Motoyoshi K (November 1998). "Association of CrkL with STAT5 in hematopoietic cells stimulated by granulocyte-macrophage colony-stimulating factor or erythropoietin". Biochemical and Biophysical Research Communications. 252 (3): 779–86. doi:10.1006/bbrc.1998.9445. PMID 9837784.
  43. ↑ 43.0 43.1 Oda A, Ochs HD, Lasky LA, Spencer S, Ozaki K, Fujihara M, Handa M, Ikebuchi K, Ikeda H (May 2001). "CrkL is an adapter for Wiskott-Aldrich syndrome protein and Syk". Blood. 97 (9): 2633–9. doi:10.1182/blood.v97.9.2633. PMID 11313252.

Further reading

  • Feller SM, Posern G, Voss J, Kardinal C, Sakkab D, Zheng J, Knudsen BS (December 1998). "Physiological signals and oncogenesis mediated through Crk family adapter proteins". Journal of Cellular Physiology. 177 (4): 535–52. doi:10.1002/(SICI)1097-4652(199812)177:4<535::AID-JCP5>3.0.CO;2-E. PMID 10092207.
  • Salgia R, Uemura N, Okuda K, Li JL, Pisick E, Sattler M, de Jong R, Druker B, Heisterkamp N, Chen LB (December 1995). "CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells". The Journal of Biological Chemistry. 270 (49): 29145–50. doi:10.1074/jbc.270.49.29145. PMID 7493940.
  • Ren R, Ye ZS, Baltimore D (April 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites". Genes & Development. 8 (7): 783–95. doi:10.1101/gad.8.7.783. PMID 7926767.
  • Oda T, Heaney C, Hagopian JR, Okuda K, Griffin JD, Druker BJ (September 1994). "Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia". The Journal of Biological Chemistry. 269 (37): 22925–8. PMID 8083188.
  • Smit L, van der Horst G, Borst J (April 1996). "Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors". The Journal of Biological Chemistry. 271 (15): 8564–9. doi:10.1074/jbc.271.15.8564. PMID 8621483.
  • Salgia R, Pisick E, Sattler M, Li JL, Uemura N, Wong WK, Burky SA, Hirai H, Chen LB, Griffin JD (October 1996). "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". The Journal of Biological Chemistry. 271 (41): 25198–203. doi:10.1074/jbc.271.41.25198. PMID 8810278.
  • Ingham RJ, Krebs DL, Barbazuk SM, Turck CW, Hirai H, Matsuda M, Gold MR (December 1996). "B cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteins". The Journal of Biological Chemistry. 271 (50): 32306–14. doi:10.1074/jbc.271.50.32306. PMID 8943292.
  • Heaney C, Kolibaba K, Bhat A, Oda T, Ohno S, Fanning S, Druker BJ (January 1997). "Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation". Blood. 89 (1): 297–306. PMID 8978305.
  • Manié SN, Beck AR, Astier A, Law SF, Canty T, Hirai H, Druker BJ, Avraham H, Haghayeghi N, Sattler M, Salgia R, Griffin JD, Golemis EA, Freedman AS (February 1997). "Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells". The Journal of Biological Chemistry. 272 (7): 4230–6. doi:10.1074/jbc.272.7.4230. PMID 9020138.
  • de Jong R, ten Hoeve J, Heisterkamp N, Groffen J (February 1997). "Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site". Oncogene. 14 (5): 507–13. doi:10.1038/sj.onc.1200885. PMID 9053848.
  • Uemura N, Salgia R, Li JL, Pisick E, Sattler M, Griffin JD (March 1997). "The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins". Leukemia. 11 (3): 376–85. doi:10.1038/sj.leu.2400590. PMID 9067577.
  • Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". The Journal of Biological Chemistry. 272 (15): 10248–53. doi:10.1074/jbc.272.15.10248. PMID 9092574.
  • Sattler M, Salgia R, Shrikhande G, Verma S, Uemura N, Law SF, Golemis EA, Griffin JD (May 1997). "Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1)". The Journal of Biological Chemistry. 272 (22): 14320–6. doi:10.1074/jbc.272.22.14320. PMID 9162067.
  • Husson H, Mograbi B, Schmid-Antomarchi H, Fischer S, Rossi B (May 1997). "CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2". Oncogene. 14 (19): 2331–8. doi:10.1038/sj.onc.1201074. PMID 9178909.
  • Chin H, Saito T, Arai A, Yamamoto K, Kamiyama R, Miyasaka N, Miura O (October 1997). "Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells". Biochemical and Biophysical Research Communications. 239 (2): 412–7. doi:10.1006/bbrc.1997.7480. PMID 9344843.
  • Ahmad S, Alsayed YM, Druker BJ, Platanias LC (November 1997). "The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein". The Journal of Biological Chemistry. 272 (48): 29991–4. doi:10.1074/jbc.272.48.29991. PMID 9374471.
  • de Jong R, van Wijk A, Haataja L, Heisterkamp N, Groffen J (December 1997). "BCR/ABL-induced leukemogenesis causes phosphorylation of Hef1 and its association with Crkl". The Journal of Biological Chemistry. 272 (51): 32649–55. doi:10.1074/jbc.272.51.32649. PMID 9405482.
  • Gesbert F, Garbay C, Bertoglio J (February 1998). "Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells". The Journal of Biological Chemistry. 273 (7): 3986–93. doi:10.1074/jbc.273.7.3986. PMID 9461587.

External links

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