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CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1gene.[1][2] This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription.
↑Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF (Dec 1988). "Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA". Science. 242 (4884): 1430–3. doi:10.1126/science.2974179. PMID2974179.
↑Taylor AK, Klisak I, Mohandas T, Sparkes RS, Li C, Gaynor R, Lusis AJ (Jul 1990). "Assignment of the human gene for CREB1 to chromosome 2q32.3-q34". Genomics. 7 (3): 416–21. doi:10.1016/0888-7543(90)90176-U. PMID2142119.
↑Kim J, Jia L, Stallcup MR, Coetzee GA (Feb 2005). "The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus". Journal of Molecular Endocrinology. 34 (1): 107–18. doi:10.1677/jme.1.01701. PMID15691881.
↑Shimomura A, Ogawa Y, Kitani T, Fujisawa H, Hagiwara M (Jul 1996). "Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein". The Journal of Biological Chemistry. 271 (30): 17957–60. doi:10.1074/jbc.271.30.17957. PMID8663317.
↑Radhakrishnan I, Pérez-Alvarado GC, Parker D, Dyson HJ, Montminy MR, Wright PE (Dec 1997). "Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions". Cell. 91 (6): 741–52. doi:10.1016/S0092-8674(00)80463-8. PMID9413984.
↑Sano Y, Tokitou F, Dai P, Maekawa T, Yamamoto T, Ishii S (Oct 1998). "CBP alleviates the intramolecular inhibition of ATF-2 function". The Journal of Biological Chemistry. 273 (44): 29098–105. doi:10.1074/jbc.273.44.29098. PMID9786917.
↑Zor T, Mayr BM, Dyson HJ, Montminy MR, Wright PE (Nov 2002). "Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators". The Journal of Biological Chemistry. 277 (44): 42241–8. doi:10.1074/jbc.M207361200. PMID12196545.
↑Gavaravarapu S, Kamine J (Mar 2000). "Tip60 inhibits activation of CREB protein by protein kinase A". Biochemical and Biophysical Research Communications. 269 (3): 758–66. doi:10.1006/bbrc.2000.2358. PMID10720489.
Don J, Stelzer G (Feb 2002). "The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis". Molecular and Cellular Endocrinology. 187 (1–2): 115–24. doi:10.1016/S0303-7207(01)00696-7. PMID11988318.
Pandey SC (Oct 2004). "The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction". Pharmacology & Therapeutics. 104 (1): 47–58. doi:10.1016/j.pharmthera.2004.08.002. PMID15500908.
Wu H, Zhou Y, Xiong ZQ (Jul 2007). "Transducer of regulated CREB and late phase long-term synaptic potentiation". The FEBS Journal. 274 (13): 3218–23. doi:10.1111/j.1742-4658.2007.05891.x. PMID17565597.
Kitagawa K (Jul 2007). "CREB and cAMP response element-mediated gene expression in the ischemic brain". The FEBS Journal. 274 (13): 3210–7. doi:10.1111/j.1742-4658.2007.05890.x. PMID17565598.
Takemori H, Kajimura J, Okamoto M (Jul 2007). "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain". The FEBS Journal. 274 (13): 3202–9. doi:10.1111/j.1742-4658.2007.05889.x. PMID17565599.