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{{Infobox_gene}}
{{PBB_Controls
'''COP9 signalosome complex subunit 2''' is a [[protein]] that in humans is encoded by the ''COPS2'' [[gene]].<ref name="pmid7776974">{{cite journal | vauthors = Lee JW, Choi HS, Gyuris J, Brent R, Moore DD | title = Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor | journal = Mol Endocrinol | volume = 9 | issue = 2 | pages = 243–54 | date = July 1995 | pmid = 7776974 | pmc =  | doi = 10.1210/me.9.2.243 }}</ref><ref name="pmid9535219">{{cite journal | vauthors = Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W | title = A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits | journal = FASEB J | volume = 12 | issue = 6 | pages = 469–78 | date = April 1998 | pmid = 9535219 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: COPS2 COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9318| accessdate = }}</ref> It encodes a subunit of the [[COP9 signalosome]].
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
| HGNCid = 30747
| Symbol = COPS2
| AltSymbols =; CSN2; ALIEN; SGN2; TRIP15
| OMIM = 604508
| ECnumber = 
| Homologene = 3124
| MGIid = 1330276
| GeneAtlas_image1 = PBB_GE_COPS2_202467_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_COPS2_209838_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0008180 |text = signalosome}}
| Process = {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9318
    | Hs_Ensembl = ENSG00000166200
    | Hs_RefseqProtein = NP_004227
    | Hs_RefseqmRNA = NM_004236
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 47206842
    | Hs_GenLoc_end = 47235072
    | Hs_Uniprot = P61201
    | Mm_EntrezGene = 12848
    | Mm_Ensembl = ENSMUSG00000027206
    | Mm_RefseqmRNA = NM_009939
    | Mm_RefseqProtein = NP_034069
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 125521745
    | Mm_GenLoc_end = 125550459
    | Mm_Uniprot = Q3UK65
  }}
}}
'''COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)''', also known as '''COPS2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: COPS2 COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9318| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box BotSee Template:PBB_Controls to Stop updates. -->
COPS2 has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
* [[DAX1]],<ref name = pmid10713076>{{cite journal | vauthors = Altincicek B, Tenbaum SP, Dressel U, Thormeyer D, Renkawitz R, Baniahmad A | title = Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita | journal = J. Biol. Chem. | volume = 275 | issue = 11 | pages = 7662–7 | date = March 2000 | pmid = 10713076 | doi = 10.1074/jbc.275.11.7662}}</ref>
| section_title =  
* [[IRF8]],<ref name = pmid10991940>{{cite journal | vauthors = Cohen H, Azriel A, Cohen T, Meraro D, Hashmueli S, Bech-Otschir D, Kraft R, Dubiel W, Levi BZ | title = Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome | journal = J. Biol. Chem. | volume = 275 | issue = 50 | pages = 39081–9 | date = December 2000 | pmid = 10991940 | doi = 10.1074/jbc.M004900200 }}</ref>  
| summary_text =  
* [[NIF3L1]],<ref name = pmid12522100>{{cite journal | vauthors = Akiyama H, Fujisawa N, Tashiro Y, Takanabe N, Sugiyama A, Tashiro F | title = The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2 | journal = J. Biol. Chem. | volume = 278 | issue = 12 | pages = 10752–62 | date = March 2003 | pmid = 12522100 | doi = 10.1074/jbc.M209856200 }}</ref>  and
}}
* [[Thyroid hormone receptor alpha|THRA]].<ref name = pmid10207062>{{cite journal | vauthors = Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A | title = Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily | journal = Mol. Cell. Biol. | volume = 19 | issue = 5 | pages = 3383–94 | date = May 1999 | pmid = 10207062 | pmc = 84131 | doi = 10.1128/mcb.19.5.3383}}</ref>


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
{{Clear}}
 
==External links==
* {{UCSC gene info|COPS2}}
* {{UCSC gene info|CSN2}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Wolf DA, Zhou C, Wee S | title = The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? | journal = Nat. Cell Biol. | volume = 5 | issue = 12 | pages = 1029–33 | year = 2004 | pmid = 14647295 | doi = 10.1038/ncb1203-1029 }}
| citations =
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Wolf DA, Zhou C, Wee S |title=The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? |journal=Nat. Cell Biol. |volume=5 |issue= 12 |pages= 1029-33 |year= 2004 |pmid= 14647295 |doi= 10.1038/ncb1203-1029 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Lee JW, Choi HS, Gyuris J, ''et al.'' |title=Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. |journal=Mol. Endocrinol. |volume=9 |issue= 2 |pages= 243-54 |year= 1995 |pmid= 7776974 |doi= }}
* {{cite journal | vauthors = Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, Deng XW | title = The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex | journal = Curr. Biol. | volume = 8 | issue = 16 | pages = 919–22 | year = 1998 | pmid = 9707402 | doi = 10.1016/S0960-9822(07)00372-7 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Schaefer L, Beermann ML, Miller JB | title = Coding sequence, genomic organization, chromosomal localization, and expression pattern of the signalosome component Cops2: the mouse homologue of Drosophila alien | journal = Genomics | volume = 56 | issue = 3 | pages = 310–6 | year = 1999 | pmid = 10087198 | doi = 10.1006/geno.1998.5728 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A | title = Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily | journal = Mol. Cell. Biol. | volume = 19 | issue = 5 | pages = 3383–94 | year = 1999 | pmid = 10207062 | pmc = 84131 | doi =  10.1128/mcb.19.5.3383}}
*{{cite journal | author=Seeger M, Kraft R, Ferrell K, ''et al.'' |title=A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. |journal=FASEB J. |volume=12 |issue= 6 |pages= 469-78 |year= 1998 |pmid= 9535219 |doi= }}
* {{cite journal | vauthors = Naumann M, Bech-Otschir D, Huang X, Ferrell K, Dubiel W | title = COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK | journal = J. Biol. Chem. | volume = 274 | issue = 50 | pages = 35297–300 | year = 2000 | pmid = 10585392 | doi = 10.1074/jbc.274.50.35297 }}
*{{cite journal | author=Wei N, Tsuge T, Serino G, ''et al.'' |title=The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. |journal=Curr. Biol. |volume=8 |issue= 16 |pages= 919-22 |year= 1998 |pmid= 9707402 |doi=  }}
* {{cite journal | vauthors = Altincicek B, Tenbaum SP, Dressel U, Thormeyer D, Renkawitz R, Baniahmad A | title = Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita | journal = J. Biol. Chem. | volume = 275 | issue = 11 | pages = 7662–7 | year = 2000 | pmid = 10713076 | doi = 10.1074/jbc.275.11.7662 }}
*{{cite journal | author=Schaefer L, Beermann ML, Miller JB |title=Coding sequence, genomic organization, chromosomal localization, and expression pattern of the signalosome component Cops2: the mouse homologue of Drosophila alien. |journal=Genomics |volume=56 |issue= 3 |pages= 310-6 |year= 1999 |pmid= 10087198 |doi= 10.1006/geno.1998.5728 }}
* {{cite journal | vauthors = Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL | title = Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 17 | pages = 9543–8 | year = 2000 | pmid = 10931946 | pmc = 16901 | doi = 10.1073/pnas.160270997 }}
*{{cite journal | author=Dressel U, Thormeyer D, Altincicek B, ''et al.'' |title=Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily. |journal=Mol. Cell. Biol. |volume=19 |issue= 5 |pages= 3383-94 |year= 1999 |pmid= 10207062 |doi= }}
* {{cite journal | vauthors = Cohen H, Azriel A, Cohen T, Meraro D, Hashmueli S, Bech-Otschir D, Kraft R, Dubiel W, Levi BZ | title = Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome | journal = J. Biol. Chem. | volume = 275 | issue = 50 | pages = 39081–9 | year = 2001 | pmid = 10991940 | doi = 10.1074/jbc.M004900200 }}
*{{cite journal | author=Naumann M, Bech-Otschir D, Huang X, ''et al.'' |title=COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK. |journal=J. Biol. Chem. |volume=274 |issue= 50 |pages= 35297-300 |year= 2000 |pmid= 10585392 |doi= }}
* {{cite journal | vauthors = Tsuge T, Matsui M, Wei N | title = The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain | journal = J. Mol. Biol. | volume = 305 | issue = 1 | pages = 1–9 | year = 2001 | pmid = 11114242 | doi = 10.1006/jmbi.2000.4288 }}
*{{cite journal | author=Altincicek B, Tenbaum SP, Dressel U, ''et al.'' |title=Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita. |journal=J. Biol. Chem. |volume=275 |issue= 11 |pages= 7662-7 |year= 2000 |pmid= 10713076 |doi= }}
* {{cite journal | vauthors = Bech-Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, Pollmann C, Dubiel W | title = COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system | journal = EMBO J. | volume = 20 | issue = 7 | pages = 1630–9 | year = 2001 | pmid = 11285227 | pmc = 145508 | doi = 10.1093/emboj/20.7.1630 }}
*{{cite journal | author=Hu RM, Han ZG, Song HD, ''et al.'' |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543-8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 }}
* {{cite journal | vauthors = Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ | title = Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome | journal = Science | volume = 292 | issue = 5520 | pages = 1382–5 | year = 2001 | pmid = 11337588 | doi = 10.1126/science.1059780 }}
*{{cite journal | author=Cohen H, Azriel A, Cohen T, ''et al.'' |title=Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome. |journal=J. Biol. Chem. |volume=275 |issue= 50 |pages= 39081-9 |year= 2001 |pmid= 10991940 |doi= 10.1074/jbc.M004900200 }}
* {{cite journal | vauthors = Hoareau Alves K, Bochard V, Réty S, Jalinot P | title = Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome | journal = FEBS Lett. | volume = 527 | issue = 1–3 | pages = 15–21 | year = 2002 | pmid = 12220626 | doi = 10.1016/S0014-5793(02)03147-2 }}
*{{cite journal | author=Tsuge T, Matsui M, Wei N |title=The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain. |journal=J. Mol. Biol. |volume=305 |issue= 1 |pages= 1-9 |year= 2001 |pmid= 11114242 |doi= 10.1006/jmbi.2000.4288 }}
* {{cite journal | vauthors = Akiyama H, Fujisawa N, Tashiro Y, Takanabe N, Sugiyama A, Tashiro F | title = The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2 | journal = J. Biol. Chem. | volume = 278 | issue = 12 | pages = 10752–62 | year = 2003 | pmid = 12522100 | doi = 10.1074/jbc.M209856200 }}
*{{cite journal | author=Bech-Otschir D, Kraft R, Huang X, ''et al.'' |title=COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. |journal=EMBO J. |volume=20 |issue= 7 |pages= 1630-9 |year= 2001 |pmid= 11285227 |doi= 10.1093/emboj/20.7.1630 }}
* {{cite journal | vauthors = Serino G, Su H, Peng Z, Tsuge T, Wei N, Gu H, Deng XW | title = Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex | journal = Plant Cell | volume = 15 | issue = 3 | pages = 719–31 | year = 2003 | pmid = 12615944 | pmc = 150025 | doi = 10.1105/tpc.009092 }}
*{{cite journal | author=Lyapina S, Cope G, Shevchenko A, ''et al.'' |title=Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. |journal=Science |volume=292 |issue= 5520 |pages= 1382-5 |year= 2001 |pmid= 11337588 |doi= 10.1126/science.1059780 }}
* {{cite journal | vauthors = Uhle S, Medalia O, Waldron R, Dumdey R, Henklein P, Bech-Otschir D, Huang X, Berse M, Sperling J, Schade R, Dubiel W | title = Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome | journal = EMBO J. | volume = 22 | issue = 6 | pages = 1302–12 | year = 2003 | pmid = 12628923 | pmc = 151059 | doi = 10.1093/emboj/cdg127 }}
*{{cite journal | author=Hoareau Alves K, Bochard V, Réty S, Jalinot P |title=Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. |journal=FEBS Lett. |volume=527 |issue= 1-3 |pages= 15-21 |year= 2002 |pmid= 12220626 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Akiyama H, Fujisawa N, Tashiro Y, ''et al.'' |title=The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2. |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10752-62 |year= 2003 |pmid= 12522100 |doi= 10.1074/jbc.M209856200 }}
*{{cite journal  | author=Serino G, Su H, Peng Z, ''et al.'' |title=Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex. |journal=Plant Cell |volume=15 |issue= 3 |pages= 719-31 |year= 2003 |pmid= 12615944 |doi=  }}
*{{cite journal  | author=Uhle S, Medalia O, Waldron R, ''et al.'' |title=Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. |journal=EMBO J. |volume=22 |issue= 6 |pages= 1302-12 |year= 2003 |pmid= 12628923 |doi= 10.1093/emboj/cdg127 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
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Latest revision as of 09:55, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

COP9 signalosome complex subunit 2 is a protein that in humans is encoded by the COPS2 gene.[1][2][3] It encodes a subunit of the COP9 signalosome.

Interactions

COPS2 has been shown to interact with:

References

  1. Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (July 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi:10.1210/me.9.2.243. PMID 7776974.
  2. Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (April 1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. PMID 9535219.
  3. "Entrez Gene: COPS2 COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)".
  4. Altincicek B, Tenbaum SP, Dressel U, Thormeyer D, Renkawitz R, Baniahmad A (March 2000). "Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita". J. Biol. Chem. 275 (11): 7662–7. doi:10.1074/jbc.275.11.7662. PMID 10713076.
  5. Cohen H, Azriel A, Cohen T, Meraro D, Hashmueli S, Bech-Otschir D, Kraft R, Dubiel W, Levi BZ (December 2000). "Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome". J. Biol. Chem. 275 (50): 39081–9. doi:10.1074/jbc.M004900200. PMID 10991940.
  6. Akiyama H, Fujisawa N, Tashiro Y, Takanabe N, Sugiyama A, Tashiro F (March 2003). "The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2". J. Biol. Chem. 278 (12): 10752–62. doi:10.1074/jbc.M209856200. PMID 12522100.
  7. Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (May 1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily". Mol. Cell. Biol. 19 (5): 3383–94. doi:10.1128/mcb.19.5.3383. PMC 84131. PMID 10207062.

External links

Further reading