CNOT8: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''CCR4-NOT transcription complex subunit 8''' is a [[protein]] that in humans is encoded by the ''CNOT8'' [[gene]].<ref name="pmid10036195">{{cite journal | vauthors = Fidler C, Wainscoat JS, Boultwood J | title = The human POP2 gene: identification, sequencing, and mapping to the critical region of the 5q- syndrome | journal = Genomics | volume = 56 | issue = 1 | pages = 134–6  | date = May 1999 | pmid = 10036195 | pmc =  | doi = 10.1006/geno.1998.5687 }}</ref><ref name="pmid10637334">{{cite journal | vauthors = Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT | title = Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits | journal = Nucleic Acids Res. | volume = 28 | issue = 3 | pages = 809–17  | date = March 2000 | pmid = 10637334 | pmc = 102560 | doi = 10.1093/nar/28.3.809 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CNOT8 CCR4-NOT transcription complex, subunit 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9337| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = CCR4-NOT transcription complex, subunit 8
| HGNCid = 9207
| Symbol = CNOT8
| AltSymbols =; CAF1; CALIF; POP2; hCAF1
| OMIM = 603731
| ECnumber = 
| Homologene = 48304
| MGIid = 1916375
| GeneAtlas_image1 = PBB_GE_CNOT8_202164_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CNOT8_202162_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_CNOT8_202163_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9337
    | Hs_Ensembl = ENSG00000155508
    | Hs_RefseqProtein = NP_004770
    | Hs_RefseqmRNA = NM_004779
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 154218299
    | Hs_GenLoc_end = 154236544
    | Hs_Uniprot = Q9UFF9
    | Mm_EntrezGene = 69125
    | Mm_Ensembl = ENSMUSG00000020515
    | Mm_RefseqmRNA = NM_026949
    | Mm_RefseqProtein = NP_081225
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 57920348
    | Mm_GenLoc_end = 57934789
    | Mm_Uniprot = Q9D8X5
  }}
}}
'''CCR4-NOT transcription complex, subunit 8''', also known as '''CNOT8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CNOT8 CCR4-NOT transcription complex, subunit 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9337| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box BotSee Template:PBB_Controls to Stop updates. -->
CNOT8 has been shown to [[Protein-protein interaction|interact]] with [[BTG2]],<ref name=pmid11136725>{{cite journal | vauthors = Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L | title = Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway | journal = J. Biol. Chem. | volume = 276 | issue = 13 | pages = 9640–8 | date = March 2001 | pmid = 11136725 | doi = 10.1074/jbc.M008201200 }}</ref> [[BTG1]],<ref name=pmid11136725/><ref name=pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8  | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref> [[CNOT1]]<ref name=pmid10637334 /><ref name=pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref> and [[CNOT3]].<ref name=pmid10637334/>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist|35em}}
==Further reading==
 
{{refbegin | 2}}
== Further reading ==
{{PBB_Further_reading
{{refbegin|35em}}
| citations =
* {{cite journal | vauthors = Bogdan JA, Adams-Burton C, Pedicord DL, Sukovich DA, Benfield PA, Corjay MH, Stoltenborg JK, Dicker IB | title = Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1 | journal = Biochem. J. | volume = 336 ( Pt 2) | issue = Pt 2 | pages = 471–81 | year = 1998 | pmid = 9820826 | pmc = 1219893 | doi =  }}
*{{cite journal | author=Bogdan JA, Adams-Burton C, Pedicord DL, ''et al.'' |title=Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1. |journal=Biochem. J. |volume=336 ( Pt 2) |issue= |pages= 471-81 |year= 1999 |pmid= 9820826 |doi= }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–95 | year = 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal  | author=Fidler C, Wainscoat JS, Boultwood J |title=The human POP2 gene: identification, sequencing, and mapping to the critical region of the 5q- syndrome. |journal=Genomics |volume=56 |issue= 1 |pages= 134-6 |year= 1999 |pmid= 10036195 |doi= 10.1006/geno.1998.5687 }}
* {{cite journal | vauthors = Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L | title = Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway | journal = J. Biol. Chem. | volume = 276 | issue = 13 | pages = 9640–8 | year = 2001 | pmid = 11136725 | doi = 10.1074/jbc.M008201200 }}
*{{cite journal  | author=Albert TK, Lemaire M, van Berkum NL, ''et al.'' |title=Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. |journal=Nucleic Acids Res. |volume=28 |issue= 3 |pages= 809-17 |year= 2000 |pmid= 10637334 |doi=  }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Res. | volume = 11 | issue = 3 | pages = 422–35 | year = 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Rep. | volume = 1 | issue = 3 | pages = 287–92 | year = 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
*{{cite journal | author=Prévôt D, Morel AP, Voeltzel T, ''et al.'' |title=Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway. |journal=J. Biol. Chem. |volume=276 |issue= 13 |pages= 9640-8 |year= 2001 |pmid= 11136725 |doi= 10.1074/jbc.M008201200 }}
* {{cite journal | vauthors = Morel AP, Sentis S, Bianchin C, Le Romancer M, Jonard L, Rostan MC, Rimokh R, Corbo L | title = BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms | journal = J. Cell Sci. | volume = 116 | issue = Pt 14 | pages = 2929–36 | year = 2003 | pmid = 12771185 | doi = 10.1242/jcs.00480 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Res. | volume = 14 | issue = 10B | pages = 2136–44 | year = 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Res. | volume = 34 | issue = Database issue | pages = D415-8 | year = 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Dorfleutner A, Bryan NB, Talbott SJ, Funya KN, Rellick SL, Reed JC, Shi X, Rojanasakul Y, Flynn DC, Stehlik C | title = Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation | journal = Infect. Immun. | volume = 75 | issue = 3 | pages = 1484–92 | year = 2007 | pmid = 17178784 | pmc = 1828547 | doi = 10.1128/IAI.01315-06 }}
*{{cite journal  | author=Morel AP, Sentis S, Bianchin C, ''et al.'' |title=BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms. |journal=J. Cell. Sci. |volume=116 |issue= Pt 14 |pages= 2929-36 |year= 2004 |pmid= 12771185 |doi= 10.1242/jcs.00480 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal | author=Dorfleutner A, Bryan NB, Talbott SJ, ''et al.'' |title=Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation. |journal=Infect. Immun. |volume=75 |issue= 3 |pages= 1484-92 |year= 2007 |pmid= 17178784 |doi= 10.1128/IAI.01315-06 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC gene info|CNOT8}}
 
 
{{gene-5-stub}}

Latest revision as of 19:36, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CCR4-NOT transcription complex subunit 8 is a protein that in humans is encoded by the CNOT8 gene.[1][2][3]

Interactions

CNOT8 has been shown to interact with BTG2,[4] BTG1,[4][5] CNOT1[2][6] and CNOT3.[2]

References

  1. Fidler C, Wainscoat JS, Boultwood J (May 1999). "The human POP2 gene: identification, sequencing, and mapping to the critical region of the 5q- syndrome". Genomics. 56 (1): 134–6. doi:10.1006/geno.1998.5687. PMID 10036195.
  2. 2.0 2.1 2.2 Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (March 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.
  3. "Entrez Gene: CNOT8 CCR4-NOT transcription complex, subunit 8".
  4. 4.0 4.1 Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L (March 2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. 276 (13): 9640–8. doi:10.1074/jbc.M008201200. PMID 11136725.
  5. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  6. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading

External links