CMV pneumonitis epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

CMV pneumonitis Microchapters

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Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating CMV pneumonitis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

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History and Symptoms

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Overview

  • Except in newborns, CMV infection is only characteristically clinically relevant in immunocompromised individuals, particularly AIDS (Acquired Immunodeficiency Syndrome) patients (CD4 <50-100) and transplant patients.
    • Approximately 40% of the U.S. have been infected.
    • Transmission is through secretions, either via sexual contact, mother-infant transmission, or prolonged close personal contact.
  • CMV is a member of the herpes family, and once a patient is infected, the virus persists and can become reactivated under immunocompromising circumstances. Sites of latency include monocytes and PMNs (polymorphonuclear leukocytes).

References