CLEC1B

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C-type lectin domain family 1 member B is a protein that in humans is encoded by the CLEC1B gene.^[1]^[2]^[3]

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.[supplied by OMIM]^[3]

References

↑ Colonna M, Samaridis J, Angman L (Mar 2000). "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells". Eur J Immunol. 30 (2): 697–704. doi:10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M. PMID 10671229.
↑ Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E (Dec 2001). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex". Eur J Immunol. 31 (12): 3493–503. doi:10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9. PMID 11745369.
↑ ^3.0 ^3.1 "Entrez Gene: CLEC1B C-type lectin domain family 1, member B".

External links

Human CLEC1B genome location and CLEC1B gene details page in the UCSC Genome Browser.
Human CLEC2B genome location and CLEC2B gene details page in the UCSC Genome Browser.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Suzuki-Inoue K, Fuller GL, García A, et al. (2006). "A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2". Blood. 107 (2): 542–9. doi:10.1182/blood-2005-05-1994. PMID 16174766.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Watson AA, O'Callaghan CA (2006). "Crystallization and X-ray diffraction analysis of human CLEC-2". Acta Crystallographica Section F. 61 (Pt 12): 1094–6. doi:10.1107/S1744309105037991. PMC 1978148. PMID 16511244.
Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12". Nature. 440 (7082): 346–51. doi:10.1038/nature04569. PMID 16541075.
Chaipan C, Soilleux EJ, Simpson P, et al. (2006). "DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets". J. Virol. 80 (18): 8951–60. doi:10.1128/JVI.00136-06. PMC 1563896. PMID 16940507.
Watson AA, Brown J, Harlos K, et al. (2007). "The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2". J. Biol. Chem. 282 (5): 3165–72. doi:10.1074/jbc.M610383200. PMID 17132623.
Suzuki-Inoue K, Kato Y, Inoue O, et al. (2007). "Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells". J. Biol. Chem. 282 (36): 25993–6001. doi:10.1074/jbc.M702327200. PMID 17616532.
Watson AA, Eble JA, O'Callaghan CA (2008). "Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC-2". Prot. Sci. 17 (9): 1611–6. doi:10.1110/ps.035568.108. PMC 2525532. PMID 18583525.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[pmid10671229-1] Colonna M, Samaridis J, Angman L (Mar 2000). "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells". Eur J Immunol. 30 (2): 697–704. doi:10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M. PMID 10671229.

[pmid11745369-2] Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E (Dec 2001). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex". Eur J Immunol. 31 (12): 3493–503. doi:10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9. PMID 11745369.

[entrez-3] 3.0 ^3.1 "Entrez Gene: CLEC1B C-type lectin domain family 1, member B".

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[2]

[3]

CLEC1B

References

External links

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