CHD4

Chromodomain helicase DNA binding protein 4
PDB rendering based on 1mm2.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1mm2​
Identifiers
Symbols	CHD4 ; DKFZp686E06161; Mi-2b; Mi2-BETA
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68175
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Chromodomain helicase DNA binding protein 4, also known as CHD4, is a human gene.

The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.

Further reading

• Denslow SA, Wade PA (2007). "The human Mi-2/NuRD complex and gene regulation". Oncogene. 26 (37): 5433–8. doi:10.1038/sj.onc.1210611. PMID 17694084.
• Ge Q, Nilasena DS, O'Brien CA; et al. (1995). "Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen". J. Clin. Invest. 96 (4): 1730–7. PMID 7560064.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seelig HP, Moosbrugger I, Ehrfeld H; et al. (1995). "The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation". Arthritis Rheum. 38 (10): 1389–99. PMID 7575689.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seelig HP, Renz M, Targoff IN; et al. (1996). "Two forms of the major antigenic protein of the dermatomyositis-specific Mi-2 autoantigen". Arthritis Rheum. 39 (10): 1769–71. PMID 8843877.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Woodage T, Basrai MA, Baxevanis AD; et al. (1997). "Characterization of the CHD family of proteins". Proc. Natl. Acad. Sci. U.S.A. 94 (21): 11472–7. PMID 9326634.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Y, LeRoy G, Seelig HP; et al. (1998). "The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities". Cell. 95 (2): 279–89. PMID 9790534.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tong JK, Hassig CA, Schnitzler GR; et al. (1998). "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex". Nature. 395 (6705): 917–21. doi:10.1038/27699. PMID 9804427.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Y, Ng HH, Erdjument-Bromage H; et al. (1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes Dev. 13 (15): 1924–35. PMID 10444591.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schmidt DR, Schreiber SL (1999). "Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4". Biochemistry. 38 (44): 14711–7. PMID 10545197.
• Humphrey GW, Wang Y, Russanova VR; et al. (2001). "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1". J. Biol. Chem. 276 (9): 6817–24. doi:10.1074/jbc.M007372200. PMID 11102443.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersen JS, Lyon CE, Fox AH; et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. PMID 11790298.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koipally J, Georgopoulos K (2002). "A molecular dissection of the repression circuitry of Ikaros". J. Biol. Chem. 277 (31): 27697–705. doi:10.1074/jbc.M201694200. PMID 12015313.
• Saito M, Ishikawa F (2002). "The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2". J. Biol. Chem. 277 (38): 35434–9. doi:10.1074/jbc.M203455200. PMID 12124384.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hakimi MA, Dong Y, Lane WS; et al. (2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". J. Biol. Chem. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kwan AH, Gell DA, Verger A; et al. (2004). "Engineering a protein scaffold from a PHD finger". Structure. 11 (7): 803–13. PMID 12842043.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shimono Y, Murakami H, Kawai K; et al. (2004). "Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities". J. Biol. Chem. 278 (51): 51638–45. doi:10.1074/jbc.M309198200. PMID 14530259.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Williams CJ, Naito T, Arco PG; et al. (2004). "The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development". Immunity. 20 (6): 719–33. doi:10.1016/j.immuni.2004.05.005. PMID 15189737.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.