CENPH: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
{{Infobox protein family
| update_page = yes
| Symbol = CENP-H
| require_manual_inspection = no
| Name = CENP-H
| update_protein_box = yes
| image =
| update_summary = yes
| width =
| update_citations = yes
| caption =
| Pfam = PF05837
| Pfam_clan = 
| InterPro = IPR008426
| SMART =
| PROSITE =
| MEROPS =
| SCOP =
| TCDB =  
| OPM family =  
| OPM protein =  
| CAZy =  
| CDD =  
}}
}}
'''Centromere protein H''' is a [[protein]] that in humans is encoded by the ''CENPH'' [[gene]].<ref name="pmid11092768">{{cite journal | vauthors = Sugata N, Li S, Earnshaw WC, Yen TJ, Yoda K, Masumoto H, Munekata E, Warburton PE, Todokoro K | title = Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes | journal = Hum Mol Genet | volume = 9 | issue = 19 | pages = 2919–26 |date=Jan 2001 | pmid = 11092768 | pmc =  | doi =10.1093/hmg/9.19.2919  }}</ref><ref name="pmid15502821">{{cite journal | vauthors = Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M | title = A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1 | journal = Nat Cell Biol | volume = 6 | issue = 11 | pages = 1135–41 |date=Nov 2004 | pmid = 15502821 | pmc =  | doi = 10.1038/ncb1187 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CENPH centromere protein H| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64946| accessdate = }}</ref>


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
 
  | image =   
[[Centromere]] and [[kinetochore]] proteins play a critical role in centromere structure, kinetochore formation, and [[Sister chromatids|sister chromatid]] separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins [[CENPA|CENP-A]] and [[CENPC|CENP-C]] in both interphase and metaphase. CENP-H is required for the localisation of CENP-C, but not CENP-A, to the centromere. However, it may be involved in the incorporation of newly synthesised CENP-A into centromeres via its interaction with the CENP-A/CENP-HI complex.<ref name="pmid11500386">{{Cite journal
  | image_source =   
  | last1 = Fukagawa | first1 = T.
  | PDB =  
  | last2 = Mikami | first2 = Y.
  | Name = Centromere protein H
  | last3 = Nishihashi | first3 = A.
  | HGNCid = 17268
  | last4 = Regnier | first4 = V.
  | Symbol = CENPH
  | last5 = Haraguchi | first5 = T.
  | AltSymbols =; PMF1; NNF1
  | last6 = Hiraoka | first6 = Y.
  | OMIM = 605607
  | last7 = Sugata | first7 = N.
  | ECnumber =   
  | last8 = Todokoro | first8 = K.
  | Homologene = 32519
  | last9 = Brown | first9 = W.
  | MGIid = 1349448
  | doi = 10.1093/emboj/20.16.4603
  | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043515 |text = kinetochore binding}}  
  | last10 = Ikemura | first10 = T.
| Component = {{GNF_GO|id=GO:0000776 |text = kinetochore}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
  | title = CENP-H, a constitutive centromere component, is required for centromere targeting of CENP-C in vertebrate cells
| Process = {{GNF_GO|id=GO:0051383 |text = kinetochore organization and biogenesis}}  
  | journal = The EMBO Journal
| Orthologs = {{GNF_Ortholog_box
  | volume = 20
    | Hs_EntrezGene = 64946
  | issue = 16
    | Hs_Ensembl = ENSG00000153044
| pages = 4603–4617
    | Hs_RefseqProtein = NP_075060
| pmc = 125570
    | Hs_RefseqmRNA = NM_022909
| year = 2001
    | Hs_GenLoc_db =
| pmid = 11500386
    | Hs_GenLoc_chr = 5
}}</ref> CENP-H localizes outside of centromeric heterochromatin, where [[CENPB|CENP-B]] is localized, and inside the kinetochore corona, where [[CENPE|CENP-E]] is localized during [[prometaphase]]. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex.<ref name="pmid10488063">{{cite journal | vauthors = Sugata N, Munekata E, Todokoro K | title = Characterization of a novel kinetochore protein, CENP-H | journal = J. Biol. Chem. | volume = 274 | issue = 39 | pages = 27343–6 |date=September 1999 | pmid = 10488063 | doi = 10.1074/jbc.274.39.27343| url = }}</ref> CENP-H contains a [[coiled coil|coiled-coil]] [[protein structure|structure]] and a [[cell nucleus|nuclear]] localisation signal.<ref name="pmid10488063" />
    | Hs_GenLoc_start = 68521131
 
    | Hs_GenLoc_end = 68541940
Studies show that CENP-H may be associated with certain [[Homo sapiens|human]] [[cancer]]s.<ref name="pmid18700042">{{cite journal | vauthors = Guo XZ, Zhang G, Wang JY, Liu WL, Wang F, Dong JQ, Xu LH, Cao JY, Song LB, Zeng MS | title = Prognostic relevance of Centromere protein H expression in esophageal carcinoma | journal = BMC Cancer | volume = 8 | issue = | pages = 233 | year = 2008 | pmid = 18700042 | pmc = 2535782 | doi = 10.1186/1471-2407-8-233 | url = }}</ref><ref name="pmid17255272">{{cite journal | vauthors = Liao WT, Song LB, Zhang HZ, Zhang X, Zhang L, Liu WL, Feng Y, Guo BH, Mai HQ, Cao SM, Li MZ, Qin HD, Zeng YX, Zeng MS | title = Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival | journal = Clin. Cancer Res. | volume = 13 | issue = 2 Pt 1 | pages = 508–14 |date=January 2007 | pmid = 17255272 | doi = 10.1158/1078-0432.CCR-06-1512 | url = }}</ref>
    | Hs_Uniprot = Q9H3R5
 
    | Mm_EntrezGene = 26886
CENP-H shows [[protein sequence|sequence]] similarity to the ''[[Schizosaccharomyces pombe]]'' kinetochore protein Fta3 which is a subunit of the Sim4 complex. This complex is required for loading the DASH complex onto the kinetochore via interaction with dad1. Fta2, Fta3 and Fta4 associate with the central core and inner [[tandem repeat|repeat]] region of the centromere.<ref name="pmid16079914">{{cite journal | vauthors = Liu X, McLeod I, Anderson S, Yates JR, He X | title = Molecular analysis of kinetochore architecture in fission yeast | journal = EMBO J. | volume = 24 | issue = 16 | pages = 2919–30 |date=August 2005 | pmid = 16079914 | pmc = 1187945 | doi = 10.1038/sj.emboj.7600762 | url = }}</ref>
    | Mm_Ensembl = ENSMUSG00000045273
    | Mm_RefseqmRNA = NM_021886
    | Mm_RefseqProtein = NP_068686
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 101859943
    | Mm_GenLoc_end = 101876156
    | Mm_Uniprot = Q9QYM8
  }}
}}
'''Centromere protein H''', also known as '''CENPH''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CENPH centromere protein H| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64946| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Other Protein Interactions==
{{PBB_Summary
CENPH has also been shown to interact with [[KIAA0090]].<ref name="pmid16845013">{{cite journal | vauthors = Prieto C, De Las Rivas J | title = APID: Agile Protein Interaction DataAnalyzer | journal = Nucleic Acids Res. | volume = 34 | issue = Web Server issue | pages = W298–302 | date = July 2006 | pmid = 16845013 | pmc = 1538863 | doi = 10.1093/nar/gkl128 | url = http://bioinfow.dep.usal.es/apid/html/home.htm | issn = | deadurl = yes | archiveurl = https://web.archive.org/web/20100409025355/http://bioinfow.dep.usal.es/apid/html/home.htm | archivedate = 2010-04-09 | df = }}</ref> The significance of this interaction is unclear.
| section_title =  
| summary_text = Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex.<ref name="entrez">{{cite web | title = Entrez Gene: CENPH centromere protein H| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64946| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CENPH}}
* {{UCSC gene info|PMF1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Sugata N, Li S, Earnshaw WC, ''et al.'' |title=Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes. |journal=Hum. Mol. Genet. |volume=9 |issue= 19 |pages= 2919-26 |year= 2001 |pmid= 11092768 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Saffery R, Sumer H, Hassan S |title=Transcription within a functional human centromere. |journal=Mol. Cell |volume=12 |issue= 2 |pages= 509–16 |year= 2003 |pmid= 14536089 |doi=10.1016/S1097-2765(03)00279-X |display-authors=etal}}
*{{cite journal  | author=Saffery R, Sumer H, Hassan S, ''et al.'' |title=Transcription within a functional human centromere. |journal=Mol. Cell |volume=12 |issue= 2 |pages= 509-16 |year= 2003 |pmid= 14536089 |doi=  }}
*{{cite journal  | vauthors=Obuse C, Yang H, Nozaki N |title=Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. |journal=Genes Cells |volume=9 |issue= 2 |pages= 105–20 |year= 2004 |pmid= 15009096 |doi=10.1111/j.1365-2443.2004.00705.x |display-authors=etal}}
*{{cite journal  | author=Obuse C, Yang H, Nozaki N, ''et al.'' |title=Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. |journal=Genes Cells |volume=9 |issue= 2 |pages= 105-20 |year= 2004 |pmid= 15009096 |doi=  }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Mikami Y, Hori T, Kimura H, Fukagawa T |title=The functional region of CENP-H interacts with the Nuf2 complex that localizes to centromere during mitosis. |journal=Mol. Cell. Biol. |volume=25 |issue= 5 |pages= 1958–70 |year= 2005 |pmid= 15713649 |doi= 10.1128/MCB.25.5.1958-1970.2005 | pmc=549355 }}
*{{cite journal | author=Obuse C, Iwasaki O, Kiyomitsu T, ''et al.'' |title=A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. |journal=Nat. Cell Biol. |volume=6 |issue= 11 |pages= 1135-41 |year= 2004 |pmid= 15502821 |doi= 10.1038/ncb1187 }}
*{{cite journal  | vauthors=Tomonaga T, Matsushita K, Ishibashi M |title=Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy. |journal=Cancer Res. |volume=65 |issue= 11 |pages= 4683–9 |year= 2005 |pmid= 15930286 |doi= 10.1158/0008-5472.CAN-04-3613 |display-authors=etal}}
*{{cite journal  | author=Mikami Y, Hori T, Kimura H, Fukagawa T |title=The functional region of CENP-H interacts with the Nuf2 complex that localizes to centromere during mitosis. |journal=Mol. Cell. Biol. |volume=25 |issue= 5 |pages= 1958-70 |year= 2005 |pmid= 15713649 |doi= 10.1128/MCB.25.5.1958-1970.2005 }}
*{{cite journal  | vauthors=Foltz DR, Jansen LE, Black BE |title=The human CENP-A centromeric nucleosome-associated complex. |journal=Nat. Cell Biol. |volume=8 |issue= 5 |pages= 458–69 |year= 2006 |pmid= 16622419 |doi= 10.1038/ncb1397 |display-authors=etal}}
*{{cite journal  | author=Tomonaga T, Matsushita K, Ishibashi M, ''et al.'' |title=Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy. |journal=Cancer Res. |volume=65 |issue= 11 |pages= 4683-9 |year= 2005 |pmid= 15930286 |doi= 10.1158/0008-5472.CAN-04-3613 }}
*{{cite journal  | vauthors=Okada M, Cheeseman IM, Hori T |title=The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. |journal=Nat. Cell Biol. |volume=8 |issue= 5 |pages= 446–57 |year= 2006 |pmid= 16622420 |doi= 10.1038/ncb1396 |display-authors=etal}}
*{{cite journal  | author=Foltz DR, Jansen LE, Black BE, ''et al.'' |title=The human CENP-A centromeric nucleosome-associated complex. |journal=Nat. Cell Biol. |volume=8 |issue= 5 |pages= 458-69 |year= 2006 |pmid= 16622419 |doi= 10.1038/ncb1397 }}
*{{cite journal  | vauthors=Izuta H, Ikeno M, Suzuki N |title=Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. |journal=Genes Cells |volume=11 |issue= 6 |pages= 673–84 |year= 2006 |pmid= 16716197 |doi= 10.1111/j.1365-2443.2006.00969.x |display-authors=etal}}
*{{cite journal  | author=Okada M, Cheeseman IM, Hori T, ''et al.'' |title=The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. |journal=Nat. Cell Biol. |volume=8 |issue= 5 |pages= 446-57 |year= 2006 |pmid= 16622420 |doi= 10.1038/ncb1396 }}
*{{cite journal  | vauthors=Orthaus S, Ohndorf S, Diekmann S |title=RNAi knockdown of human kinetochore protein CENP-H. |journal=Biochem. Biophys. Res. Commun. |volume=348 |issue= 1 |pages= 36–46 |year= 2006 |pmid= 16875666 |doi= 10.1016/j.bbrc.2006.06.187 }}
*{{cite journal  | author=Izuta H, Ikeno M, Suzuki N, ''et al.'' |title=Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. |journal=Genes Cells |volume=11 |issue= 6 |pages= 673-84 |year= 2006 |pmid= 16716197 |doi= 10.1111/j.1365-2443.2006.00969.x }}
*{{cite journal  | vauthors=Liao WT, Song LB, Zhang HZ |title=Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival. |journal=Clin. Cancer Res. |volume=13 |issue= 2 Pt 1 |pages= 508–14 |year= 2007 |pmid= 17255272 |doi= 10.1158/1078-0432.CCR-06-1512 |display-authors=etal}}
*{{cite journal  | author=Orthaus S, Ohndorf S, Diekmann S |title=RNAi knockdown of human kinetochore protein CENP-H. |journal=Biochem. Biophys. Res. Commun. |volume=348 |issue= 1 |pages= 36-46 |year= 2006 |pmid= 16875666 |doi= 10.1016/j.bbrc.2006.06.187 }}
*{{cite journal  | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
*{{cite journal  | author=Liao WT, Song LB, Zhang HZ, ''et al.'' |title=Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival. |journal=Clin. Cancer Res. |volume=13 |issue= 2 Pt 1 |pages= 508-14 |year= 2007 |pmid= 17255272 |doi= 10.1158/1078-0432.CCR-06-1512 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Chromosome genetics}}
{{Chromosome genetics}}
{{WikiDoc Sources}}
{{InterPro content|IPR008426}}
 
[[Category:Protein domains]]
 
 
{{gene-5-stub}}

Latest revision as of 09:33, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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n/a

UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human
CENP-H
Identifiers
SymbolCENP-H
PfamPF05837
InterProIPR008426

Centromere protein H is a protein that in humans is encoded by the CENPH gene.[1][2][3]

Function

Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. CENP-H is required for the localisation of CENP-C, but not CENP-A, to the centromere. However, it may be involved in the incorporation of newly synthesised CENP-A into centromeres via its interaction with the CENP-A/CENP-HI complex.[4] CENP-H localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex.[5] CENP-H contains a coiled-coil structure and a nuclear localisation signal.[5]

Studies show that CENP-H may be associated with certain human cancers.[6][7]

CENP-H shows sequence similarity to the Schizosaccharomyces pombe kinetochore protein Fta3 which is a subunit of the Sim4 complex. This complex is required for loading the DASH complex onto the kinetochore via interaction with dad1. Fta2, Fta3 and Fta4 associate with the central core and inner repeat region of the centromere.[8]

Other Protein Interactions

CENPH has also been shown to interact with KIAA0090.[9] The significance of this interaction is unclear.

References

  1. ↑ Sugata N, Li S, Earnshaw WC, Yen TJ, Yoda K, Masumoto H, Munekata E, Warburton PE, Todokoro K (Jan 2001). "Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes". Hum Mol Genet. 9 (19): 2919–26. doi:10.1093/hmg/9.19.2919. PMID 11092768.
  2. ↑ Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat Cell Biol. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821.
  3. ↑ "Entrez Gene: CENPH centromere protein H".
  4. ↑ Fukagawa, T.; Mikami, Y.; Nishihashi, A.; Regnier, V.; Haraguchi, T.; Hiraoka, Y.; Sugata, N.; Todokoro, K.; Brown, W.; Ikemura, T. (2001). "CENP-H, a constitutive centromere component, is required for centromere targeting of CENP-C in vertebrate cells". The EMBO Journal. 20 (16): 4603–4617. doi:10.1093/emboj/20.16.4603. PMC 125570. PMID 11500386.
  5. ↑ 5.0 5.1 Sugata N, Munekata E, Todokoro K (September 1999). "Characterization of a novel kinetochore protein, CENP-H". J. Biol. Chem. 274 (39): 27343–6. doi:10.1074/jbc.274.39.27343. PMID 10488063.
  6. ↑ Guo XZ, Zhang G, Wang JY, Liu WL, Wang F, Dong JQ, Xu LH, Cao JY, Song LB, Zeng MS (2008). "Prognostic relevance of Centromere protein H expression in esophageal carcinoma". BMC Cancer. 8: 233. doi:10.1186/1471-2407-8-233. PMC 2535782. PMID 18700042.
  7. ↑ Liao WT, Song LB, Zhang HZ, Zhang X, Zhang L, Liu WL, Feng Y, Guo BH, Mai HQ, Cao SM, Li MZ, Qin HD, Zeng YX, Zeng MS (January 2007). "Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival". Clin. Cancer Res. 13 (2 Pt 1): 508–14. doi:10.1158/1078-0432.CCR-06-1512. PMID 17255272.
  8. ↑ Liu X, McLeod I, Anderson S, Yates JR, He X (August 2005). "Molecular analysis of kinetochore architecture in fission yeast". EMBO J. 24 (16): 2919–30. doi:10.1038/sj.emboj.7600762. PMC 1187945. PMID 16079914.
  9. ↑ Prieto C, De Las Rivas J (July 2006). "APID: Agile Protein Interaction DataAnalyzer". Nucleic Acids Res. 34 (Web Server issue): W298–302. doi:10.1093/nar/gkl128. PMC 1538863. PMID 16845013. Archived from the original on 2010-04-09.

External links

Further reading

This article incorporates text from the public domain Pfam and InterPro: IPR008426


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