CDC40: Difference between revisions

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{{Infobox_gene}}
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'''Pre-mRNA-processing factor 17''' is a [[protein]] that in humans is encoded by the ''CDC40'' [[gene]].<ref name="pmid9769104">{{cite journal | vauthors = Ben Yehuda S, Dix I, Russell CS, Levy S, Beggs JD, Kupiec M | title = Identification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle control | journal = RNA | volume = 4 | issue = 10 | pages = 1304–12 |date=Oct 1998 | pmid = 9769104 | pmc = 1369702 | doi =10.1017/S1355838298980712 }}</ref><ref name="pmid9830021">{{cite journal | vauthors = Lindsey LA, Garcia-Blanco MA | title = Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p | journal = J Biol Chem | volume = 273 | issue = 49 | pages = 32771–5 |date=Jan 1999 | pmid = 9830021 | pmc =  | doi =10.1074/jbc.273.49.32771 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDC40 cell division cycle 40 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51362| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cell division cycle 40 homolog (S. cerevisiae)
| HGNCid = 17350
| Symbol = CDC40
| AltSymbols =; EHB3; FLJ10564; MGC102802; PRP17; PRPF17
| OMIM = 605585
| ECnumber =
| Homologene = 5716
| MGIid = 1918963
| GeneAtlas_image1 = PBB_GE_CDC40_203376_at_tn.png
| GeneAtlas_image2 = PBB_GE_CDC40_203377_s_at_tn.png
| Function =
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51362
    | Hs_Ensembl = ENSG00000168438
    | Hs_RefseqProtein = NP_056975
    | Hs_RefseqmRNA = NM_015891
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 110608037
    | Hs_GenLoc_end = 110682171
    | Hs_Uniprot = O60508
    | Mm_EntrezGene = 71713
    | Mm_Ensembl = ENSMUSG00000038446
    | Mm_RefseqmRNA = XM_483893
    | Mm_RefseqProtein = XP_483893
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 40520228
    | Mm_GenLoc_end = 40571524
    | Mm_Uniprot = Q3UXN9
  }}
}}
'''Cell division cycle 40 homolog (S. cerevisiae)''', also known as '''CDC40''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDC40 cell division cycle 40 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51362| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression.<ref name="entrez">{{cite web | title = Entrez Gene: CDC40 cell division cycle 40 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51362| accessdate = }}</ref>
| summary_text = Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CDC40}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Wong WT, Schumacher C, Salcini AE, ''et al.'' |title=A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 21 |pages= 9530-4 |year= 1995 |pmid= 7568168 |doi=  }}
*{{cite journal  | vauthors=Wong WT, Schumacher C, Salcini AE |title=A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 21 |pages= 9530–4 |year= 1995 |pmid= 7568168 |doi=10.1073/pnas.92.21.9530 | pmc=40835  |display-authors=etal}}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Salcini AE, Confalonieri S, Doria M, ''et al.'' |title=Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. |journal=Genes Dev. |volume=11 |issue= 17 |pages= 2239-49 |year= 1997 |pmid= 9303539 |doi=  }}
*{{cite journal  | vauthors=Salcini AE, Confalonieri S, Doria M |title=Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module |journal=Genes Dev. |volume=11 |issue= 17 |pages= 2239–49 |year= 1997 |pmid= 9303539 |doi=10.1101/gad.11.17.2239 | pmc=275390  |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Zhou Z, Reed R |title=Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing. |journal=EMBO J. |volume=17 |issue= 7 |pages= 2095-106 |year= 1998 |pmid= 9524131 |doi= 10.1093/emboj/17.7.2095 }}
*{{cite journal  | vauthors=Zhou Z, Reed R |title=Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing |journal=EMBO J. |volume=17 |issue= 7 |pages= 2095–106 |year= 1998 |pmid= 9524131 |doi= 10.1093/emboj/17.7.2095  | pmc=1170554 }}
*{{cite journal  | author=Ben Yehuda S, Dix I, Russell CS, ''et al.'' |title=Identification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle control. |journal=RNA |volume=4 |issue= 10 |pages= 1304-12 |year= 1998 |pmid= 9769104 |doi=  }}
*{{cite journal  | vauthors=Ben-Yehuda S, Dix I, Russell CS |title=Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae |journal=Genetics |volume=156 |issue= 4 |pages= 1503–17 |year= 2001 |pmid= 11102353 |doi=  | pmc=1461362  |display-authors=etal}}
*{{cite journal | author=Lindsey LA, Garcia-Blanco MA |title=Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p. |journal=J. Biol. Chem. |volume=273 |issue= 49 |pages= 32771-5 |year= 1999 |pmid= 9830021 |doi=  }}
*{{cite journal  | vauthors=Jurica MS, Licklider LJ, Gygi SR |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=10.1017/S1355838202021088  | pmc=1370266 |display-authors=etal}}
*{{cite journal  | author=Ben-Yehuda S, Dix I, Russell CS, ''et al.'' |title=Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae. |journal=Genetics |volume=156 |issue= 4 |pages= 1503-17 |year= 2001 |pmid= 11102353 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Jurica MS, Licklider LJ, Gygi SR, ''et al.'' |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426-39 |year= 2002 |pmid= 11991638 |doi=  }}
*{{cite journal  | vauthors=Mungall AJ, Palmer SA, Sims SK |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Barrios-Rodiles M, Brown KR, Ozdamar B |title=High-throughput mapping of a dynamic signaling network in mammalian cells |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
*{{cite journal  | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 09:26, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (mRNA)

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Wikidata
View/Edit Human

Pre-mRNA-processing factor 17 is a protein that in humans is encoded by the CDC40 gene.[1][2][3]

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression.[3]

References

  1. ↑ Ben Yehuda S, Dix I, Russell CS, Levy S, Beggs JD, Kupiec M (Oct 1998). "Identification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle control". RNA. 4 (10): 1304–12. doi:10.1017/S1355838298980712. PMC 1369702. PMID 9769104.
  2. ↑ Lindsey LA, Garcia-Blanco MA (Jan 1999). "Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p". J Biol Chem. 273 (49): 32771–5. doi:10.1074/jbc.273.49.32771. PMID 9830021.
  3. ↑ 3.0 3.1 "Entrez Gene: CDC40 cell division cycle 40 homolog (S. cerevisiae)".

External links

Further reading



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