CD2AP: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''CD2-associated protein''' is a [[protein]] that in humans is encoded by the ''CD2AP'' [[gene]].<ref name="pmid10339567">{{cite journal | vauthors = Kirsch KH, Georgescu MM, Ishimaru S, Hanafusa H | title = CMS: An adapter molecule involved in cytoskeletal rearrangements | journal = Proc Natl Acad Sci USA | volume = 96 | issue = 11 | pages = 6211–6 | date = Jun 1999 | pmid = 10339567 | pmc = 26861 | doi = 10.1073/pnas.96.11.6211 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CD2AP CD2-associated protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23607| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_CD2AP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2j6f.
| PDB = {{PDB2|2j6f}}, {{PDB2|2j6k}}, {{PDB2|2j6o}}, {{PDB2|2j7i}}
| Name = CD2-associated protein
| HGNCid = 14258
| Symbol = CD2AP
| AltSymbols =; CMS; DKFZP586H0519
| OMIM = 604241
| ECnumber = 
| Homologene = 7663
| MGIid = 1330281
| Function = {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0017124 |text = SH3 domain binding}}
| Component = {{GNF_GO|id=GO:0001726 |text = ruffle}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}} {{GNF_GO|id=GO:0031941 |text = filamentous actin}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006930 |text = substrate-bound cell migration, cell extension}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23607
    | Hs_Ensembl = ENSG00000198087
    | Hs_RefseqProtein = NP_036252
    | Hs_RefseqmRNA = NM_012120
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 47553899
    | Hs_GenLoc_end = 47702620
    | Hs_Uniprot = Q9Y5K6
    | Mm_EntrezGene = 12488
    | Mm_Ensembl = ENSMUSG00000061665
    | Mm_RefseqmRNA = NM_009847
    | Mm_RefseqProtein = NP_033977
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 42259812
    | Mm_GenLoc_end = 42316016
    | Mm_Uniprot = Q9JLQ0
  }}
}}
'''CD2-associated protein''', also known as '''CD2AP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CD2AP CD2-associated protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23607| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, [[SH3 domain]]s, and a [[proline]]-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to [[Membrane ruffling|membrane ruffles]], [[lipid raft]]s, and the leading edges of cells. It is implicated in dynamic [[actin remodeling]] and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.<ref name="entrez">{{cite web | title = Entrez Gene: CD2AP CD2-associated protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23607| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
CD2AP has been shown to [[Protein-protein interaction|interact]] with:
* [[Cbl gene]],<ref name = pmid15128873>{{cite journal | vauthors = Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I | title = Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites | journal = J. Cell Sci. | volume = 117 | issue = Pt 12 | pages = 2557–68 | date = May 2004 | pmid = 15128873 | doi = 10.1242/jcs.01148 }}</ref><ref name = pmid11067845>{{cite journal | vauthors = Kirsch KH, Georgescu MM, Shishido T, Langdon WY, Birge RB, Hanafusa H | title = The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction | journal = J. Biol. Chem. | volume = 276 | issue = 7 | pages = 4957–63 | date = Feb 2001 | pmid = 11067845 | doi = 10.1074/jbc.M005784200 }}</ref><ref name = pmid12559036>{{cite journal | vauthors = Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, McGraw TE, Le Marchand-Brustel Y | title = CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl | journal = Traffic | volume = 4 | issue = 2 | pages = 97–112 | date = Feb 2003 | pmid = 12559036 | doi =  10.1034/j.1600-0854.2003.40205.x}}</ref>
* [[NPHS2]],<ref name = pmid11733557>{{cite journal | vauthors = Schwarz K, Simons M, Reiser J, Saleem MA, Faul C, Kriz W, Shaw AS, Holzman LB, Mundel P | title = Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin | journal = J. Clin. Invest. | volume = 108 | issue = 11 | pages = 1621–9 | date = Dec 2001 | pmid = 11733557 | pmc = 200981 | doi = 10.1172/JCI12849 }}</ref>
* [[Nephrin]],<ref name = pmid15331416>{{cite journal | vauthors = Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG | title = Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin | journal = Am. J. Pathol. | volume = 165 | issue = 3 | pages = 923–36 | date = Sep 2004 | pmid = 15331416 | pmc = 1618613 | doi = 10.1016/S0002-9440(10)63354-8 }}</ref>  and
* [[RAB4A]].<ref name = pmid12559036/>
 
== See also ==
* [[Focal segmental glomerulosclerosis]]
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1997 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
| citations =
* {{cite journal | vauthors = Dustin ML, Olszowy MW, Holdorf AD, Li J, Bromley S, Desai N, Widder P, Rosenberger F, van der Merwe PA, Allen PM, Shaw AS | title = A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts | journal = Cell | volume = 94 | issue = 5 | pages = 667–77 | year = 1998 | pmid = 9741631 | doi = 10.1016/S0092-8674(00)81608-6|url=https://zenodo.org/record/1065005 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Lehtonen S, Ora A, Olkkonen VM, Geng L, Zerial M, Somlo S, Lehtonen E | title = In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2 | journal = J. Biol. Chem. | volume = 275 | issue = 42 | pages = 32888–93 | year = 2000 | pmid = 10913159 | doi = 10.1074/jbc.M006624200 }}
*{{cite journal | author=Dustin ML, Olszowy MW, Holdorf AD, ''et al.'' |title=A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. |journal=Cell |volume=94 |issue= 5 |pages= 667-77 |year= 1998 |pmid= 9741631 |doi= }}
* {{cite journal | vauthors = Li C, Ruotsalainen V, Tryggvason K, Shaw AS, Miner JH | title = CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere | journal = Am. J. Physiol. Renal Physiol. | volume = 279 | issue = 4 | pages = F785–92 | year = 2000 | pmid = 10997929 | doi = }}
*{{cite journal | author=Kirsch KH, Georgescu MM, Ishimaru S, Hanafusa H |title=CMS: an adapter molecule involved in cytoskeletal rearrangements. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 11 |pages= 6211-6 |year= 1999 |pmid= 10339567 |doi= }}
* {{cite journal | vauthors = Kirsch KH, Georgescu MM, Shishido T, Langdon WY, Birge RB, Hanafusa H | title = The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction | journal = J. Biol. Chem. | volume = 276 | issue = 7 | pages = 4957–63 | year = 2001 | pmid = 11067845 | doi = 10.1074/jbc.M005784200 }}
*{{cite journal | author=Lehtonen S, Ora A, Olkkonen VM, ''et al.'' |title=In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2. |journal=J. Biol. Chem. |volume=275 |issue= 42 |pages= 32888-93 |year= 2000 |pmid= 10913159 |doi= 10.1074/jbc.M006624200 }}
* {{cite journal | vauthors = Schwarz K, Simons M, Reiser J, Saleem MA, Faul C, Kriz W, Shaw AS, Holzman LB, Mundel P | title = Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin | journal = J. Clin. Invest. | volume = 108 | issue = 11 | pages = 1621–9 | year = 2002 | pmid = 11733557 | pmc = 200981 | doi = 10.1172/JCI12849 }}
*{{cite journal | author=Li C, Ruotsalainen V, Tryggvason K, ''et al.'' |title=CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere. |journal=Am. J. Physiol. Renal Physiol. |volume=279 |issue= 4 |pages= F785-92 |year= 2000 |pmid= 10997929 |doi= }}
* {{cite journal | vauthors = Scott MP, Zappacosta F, Kim EY, Annan RS, Miller WT | title = Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1 | journal = J. Biol. Chem. | volume = 277 | issue = 31 | pages = 28238–46 | year = 2002 | pmid = 12029088 | doi = 10.1074/jbc.M202783200 }}
*{{cite journal | author=Kirsch KH, Georgescu MM, Shishido T, ''et al.'' |title=The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 4957-63 |year= 2001 |pmid= 11067845 |doi= 10.1074/jbc.M005784200 }}
* {{cite journal | vauthors = Badour K, Zhang J, Shi F, McGavin MK, Rampersad V, Hardy LA, Field D, Siminovitch KA | title = The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse | journal = Immunity | volume = 18 | issue = 1 | pages = 141–54 | year = 2003 | pmid = 12530983 | doi = 10.1016/S1074-7613(02)00516-2 }}
*{{cite journal | author=Schwarz K, Simons M, Reiser J, ''et al.'' |title=Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin. |journal=J. Clin. Invest. |volume=108 |issue= 11 |pages= 1621-9 |year= 2002 |pmid= 11733557 |doi= }}
* {{cite journal | vauthors = Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, McGraw TE, Le Marchand-Brustel Y | title = CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl | journal = Traffic | volume = 4 | issue = 2 | pages = 97–112 | year = 2003 | pmid = 12559036 | doi = 10.1034/j.1600-0854.2003.40205.x }}
*{{cite journal | author=Scott MP, Zappacosta F, Kim EY, ''et al.'' |title=Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 28238-46 |year= 2002 |pmid= 12029088 |doi= 10.1074/jbc.M202783200 }}
* {{cite journal | vauthors = Lynch DK, Winata SC, Lyons RJ, Hughes WE, Lehrbach GM, Wasinger V, Corthals G, Cordwell S, Daly RJ | title = A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton | journal = J. Biol. Chem. | volume = 278 | issue = 24 | pages = 21805–13 | year = 2003 | pmid = 12672817 | doi = 10.1074/jbc.M211407200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Hutchings NJ, Clarkson N, Chalkley R, Barclay AN, Brown MH | title = Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85 | journal = J. Biol. Chem. | volume = 278 | issue = 25 | pages = 22396–403 | year = 2003 | pmid = 12690097 | doi = 10.1074/jbc.M302540200 }}
*{{cite journal | author=Badour K, Zhang J, Shi F, ''et al.'' |title=The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse. |journal=Immunity |volume=18 |issue= 1 |pages= 141-54 |year= 2003 |pmid= 12530983 |doi= }}
* {{cite journal | vauthors = Kim JM, Wu H, Green G, Winkler CA, Kopp JB, Miner JH, Unanue ER, Shaw AS | title = CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility | journal = Science | volume = 300 | issue = 5623 | pages = 1298–300 | year = 2003 | pmid = 12764198 | doi = 10.1126/science.1081068 }}
*{{cite journal | author=Cormont M, Metón I, Mari M, ''et al.'' |title=CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl. |journal=Traffic |volume=4 |issue= 2 |pages= 97-112 |year= 2003 |pmid= 12559036 |doi= }}
* {{cite journal | vauthors = Schulze WX, Mann M | title = A novel proteomic screen for peptide-protein interactions | journal = J. Biol. Chem. | volume = 279 | issue = 11 | pages = 10756–64 | year = 2004 | pmid = 14679214 | doi = 10.1074/jbc.M309909200 }}
*{{cite journal | author=Lynch DK, Winata SC, Lyons RJ, ''et al.'' |title=A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton. |journal=J. Biol. Chem. |volume=278 |issue= 24 |pages= 21805-13 |year= 2003 |pmid= 12672817 |doi= 10.1074/jbc.M211407200 }}
* {{cite journal | vauthors = Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I | title = Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites | journal = J. Cell Sci. | volume = 117 | issue = Pt 12 | pages = 2557–68 | year = 2004 | pmid = 15128873 | doi = 10.1242/jcs.01148 }}
*{{cite journal | author=Hutchings NJ, Clarkson N, Chalkley R, ''et al.'' |title=Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85. |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 22396-403 |year= 2003 |pmid= 12690097 |doi= 10.1074/jbc.M302540200 }}
* {{cite journal | vauthors = Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG | title = Nephrin Forms a Complex with Adherens Junction Proteins and CASK in Podocytes and in Madin-Darby Canine Kidney Cells Expressing Nephrin | journal = Am. J. Pathol. | volume = 165 | issue = 3 | pages = 923–36 | year = 2004 | pmid = 15331416 | pmc = 1618613 | doi = 10.1016/S0002-9440(10)63354-8 }}
*{{cite journal | author=Kim JM, Wu H, Green G, ''et al.'' |title=CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility. |journal=Science |volume=300 |issue= 5623 |pages= 1298-300 |year= 2003 |pmid= 12764198 |doi= 10.1126/science.1081068 }}
* {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nat. Biotechnol. | volume = 23 | issue = 1 | pages = 94–101 | year = 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 }}
*{{cite journal | author=Schulze WX, Mann M |title=A novel proteomic screen for peptide-protein interactions. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10756-64 |year= 2004 |pmid= 14679214 |doi= 10.1074/jbc.M309909200 }}
* {{cite journal | vauthors = Coward RJ, Foster RR, Patton D, Ni L, Lennon R, Bates DO, Harper SJ, Mathieson PW, Saleem MA | title = Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes | journal = J. Am. Soc. Nephrol. | volume = 16 | issue = 3 | pages = 629–37 | year = 2005 | pmid = 15659563 | doi = 10.1681/ASN.2004030172 }}
*{{cite journal | author=Haglund K, Ivankovic-Dikic I, Shimokawa N, ''et al.'' |title=Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. |journal=J. Cell. Sci. |volume=117 |issue= Pt 12 |pages= 2557-68 |year= 2004 |pmid= 15128873 |doi= 10.1242/jcs.01148 }}
*{{cite journal | author=Lehtonen S, Lehtonen E, Kudlicka K, ''et al.'' |title=Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin. |journal=Am. J. Pathol. |volume=165 |issue= 3 |pages= 923-36 |year= 2004 |pmid= 15331416 |doi=  }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal  | author=Coward RJ, Foster RR, Patton D, ''et al.'' |title=Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes. |journal=J. Am. Soc. Nephrol. |volume=16 |issue= 3 |pages= 629-37 |year= 2005 |pmid= 15659563 |doi= 10.1681/ASN.2004030172 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC gene info|CD2AP}}
{{PDB Gallery|geneid=23607}}
 
 
{{gene-6-stub}}

Latest revision as of 10:18, 24 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CD2-associated protein is a protein that in humans is encoded by the CD2AP gene.[1][2]

Function

This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.[2]

Interactions

CD2AP has been shown to interact with:

See also

References

  1. ↑ Kirsch KH, Georgescu MM, Ishimaru S, Hanafusa H (Jun 1999). "CMS: An adapter molecule involved in cytoskeletal rearrangements". Proc Natl Acad Sci USA. 96 (11): 6211–6. doi:10.1073/pnas.96.11.6211. PMC 26861. PMID 10339567.
  2. ↑ 2.0 2.1 "Entrez Gene: CD2AP CD2-associated protein".
  3. ↑ Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I (May 2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". J. Cell Sci. 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. PMID 15128873.
  4. ↑ Kirsch KH, Georgescu MM, Shishido T, Langdon WY, Birge RB, Hanafusa H (Feb 2001). "The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction". J. Biol. Chem. 276 (7): 4957–63. doi:10.1074/jbc.M005784200. PMID 11067845.
  5. ↑ 5.0 5.1 Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, McGraw TE, Le Marchand-Brustel Y (Feb 2003). "CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl". Traffic. 4 (2): 97–112. doi:10.1034/j.1600-0854.2003.40205.x. PMID 12559036.
  6. ↑ Schwarz K, Simons M, Reiser J, Saleem MA, Faul C, Kriz W, Shaw AS, Holzman LB, Mundel P (Dec 2001). "Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin". J. Clin. Invest. 108 (11): 1621–9. doi:10.1172/JCI12849. PMC 200981. PMID 11733557.
  7. ↑ Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG (Sep 2004). "Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin". Am. J. Pathol. 165 (3): 923–36. doi:10.1016/S0002-9440(10)63354-8. PMC 1618613. PMID 15331416.

Further reading

External links


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