CCNG1

Cyclin G1
Identifiers
Symbols	CCNG1 ; CCNG
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2995
Gene ontology Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cyclin G1, also known as CCNG1, is a human gene.

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene.

Further reading

• Horne MC, Goolsby GL, Donaldson KL; et al. (1996). "Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression". J. Biol. Chem. 271 (11): 6050–61. PMID 8626390.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bates S, Rowan S, Vousden KH (1996). "Characterisation of human cyclin G1 and G2: DNA damage inducible genes". Oncogene. 13 (5): 1103–9. PMID 8806701.CS1 maint: Multiple names: authors list (link)
• Okamoto K, Kamibayashi C, Serrano M; et al. (1996). "p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A". Mol. Cell. Biol. 16 (11): 6593–602. PMID 8887688.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Endo Y, Fujita T, Tamura K; et al. (1997). "Structure and chromosomal assignment of the human cyclin G gene". Genomics. 38 (1): 92–5. doi:10.1006/geno.1996.0598. PMID 8954786.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kanaoka Y, Kimura SH, Okazaki I; et al. (1997). "GAK: a cyclin G associated kinase contains a tensin/auxilin-like domain". FEBS Lett. 402 (1): 73–80. PMID 9013862.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kato MV (1999). "The mechanisms of death of an erythroleukemic cell line by p53: involvement of the microtubule and mitochondria". Leuk. Lymphoma. 33 (1–2): 181–6. PMID 10194136.
• Reimer CL, Borras AM, Kurdistani SK; et al. (1999). "Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells". J. Biol. Chem. 274 (16): 11022–9. PMID 10196184.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bennin DA, Don AS, Brake T; et al. (2002). "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest". J. Biol. Chem. 277 (30): 27449–67. doi:10.1074/jbc.M111693200. PMID 11956189.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jordan-Sciutto KL, Morgan K, Bowser R. "Increased Cyclin G1 Immunoreactivity During Alzheimer's Disease". 1 (6): 409–417. PMID 12214116.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhao L, Samuels T, Winckler S; et al. (2003). "Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways". Mol. Cancer Res. 1 (3): 195–206. PMID 12556559.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baek WK, Kim D, Jung N; et al. (2003). "Increased expression of cyclin G1 in leiomyoma compared with normal myometrium". Am. J. Obstet. Gynecol. 188 (3): 634–9. PMID 12634633.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li JQ, Kubo A, Wu F; et al. (2003). "Cyclin B1, unlike cyclin G1, increases significantly during colorectal carcinogenesis and during later metastasis to lymph nodes". Int. J. Oncol. 22 (5): 1101–10. PMID 12684677.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohtsuka T, Jensen MR, Kim HG; et al. (2004). "The negative role of cyclin G in ATM-dependent p53 activation". Oncogene. 23 (31): 5405–8. doi:10.1038/sj.onc.1207693. PMID 15077171.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seo HR, Lee DH, Lee HJ; et al. (2006). "Cyclin G1 overcomes radiation-induced G2 arrest and increases cell death through transcriptional activation of cyclin B1". Cell Death Differ. 13 (9): 1475–84. doi:10.1038/sj.cdd.4401822. PMID 16322753.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gramantieri L, Ferracin M, Fornari F; et al. (2007). "Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma". Cancer Res. 67 (13): 6092–9. doi:10.1158/0008-5472.CAN-06-4607. PMID 17616664.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)