CCNF

Cyclin F
Identifiers
Symbols	CCNF ; FBX1; FBXO1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1335
Gene ontology Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cyclin F, also known as CCNF, is a human gene.

This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified.

Further reading

• Nehls M, Lüno K, Schorpp M; et al. (1995). "YAC/P1 contigs defining the location of 56 microsatellite markers and several genes across a 3.4-cM interval on mouse chromosome 11". Mamm. Genome. 6 (5): 321–31. PMID 7626882.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bai C, Richman R, Elledge SJ (1995). "Human cyclin F.". EMBO J. 13 (24): 6087–98. PMID 7813445.CS1 maint: Multiple names: authors list (link)
• Kraus B, Pohlschmidt M, Leung AL; et al. (1995). "A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1)". Genomics. 24 (1): 27–33. doi:10.1006/geno.1994.1578. PMID 7896286.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bai C, Sen P, Hofmann K; et al. (1996). "SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box". Cell. 86 (2): 263–74. PMID 8706131.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kong M, Barnes EA, Ollendorff V, Donoghue DJ (2000). "Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction". EMBO J. 19 (6): 1378–88. doi:10.1093/emboj/19.6.1378. PMID 10716937.CS1 maint: Multiple names: authors list (link)
• Fung TK, Siu WY, Yam CH; et al. (2002). "Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins". J. Biol. Chem. 277 (38): 35140–9. doi:10.1074/jbc.M205503200. PMID 12122006.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)