CASP8AP2

CASP8 associated protein 2
Identifiers
Symbols	CASP8AP2 ; CED-4; FLASH; FLJ11208; KIAA1315; RIP25
External IDs	Template:OMIM5 Template:MGI HomoloGene: 8066
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

CASP8 associated protein 2, also known as CASP8AP2, is a human gene.

This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis.

Further reading

• Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. PMID 12168954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Imai Y, Kimura T, Murakami A; et al. (1999). "The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis". Nature. 398 (6730): 777–85. doi:10.1038/19709. PMID 10235259.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koonin EV, Aravind L, Hofmann K; et al. (1999). "Apoptosis. Searching for FLASH domains". Nature. 401 (6754): 662, discussion 662-3. doi:10.1038/44317. PMID 10537104.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Kikuno R, Ishikawa KI; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. PMID 10718198.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Choi YH, Kim KB, Kim HH; et al. (2001). "FLASH coordinates NF-kappa B activity via TRAF2". J. Biol. Chem. 276 (27): 25073–7. doi:10.1074/jbc.M102941200. PMID 11340079.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kino T, Chrousos GP (2003). "Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators". J. Biol. Chem. 278 (5): 3023–9. doi:10.1074/jbc.M209234200. PMID 12477726.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jun JI, Chung CW, Lee HJ; et al. (2005). "Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway". Oncogene. 24 (4): 688–96. doi:10.1038/sj.onc.1208186. PMID 15592525.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kino T, Ichijo T, Chrousos GP (2005). "FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors". J. Steroid Biochem. Mol. Biol. 92 (5): 357–63. doi:10.1016/j.jsbmb.2004.09.003. PMID 15698540.CS1 maint: Multiple names: authors list (link)
• Flotho C, Coustan-Smith E, Pei D; et al. (2006). "Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2". Blood. 108 (3): 1050–7. doi:10.1182/blood-2006-01-0322. PMID 16627760.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barcaroli D, Bongiorno-Borbone L, Terrinoni A; et al. (2006). "FLASH is required for histone transcription and S-phase progression". Proc. Natl. Acad. Sci. U.S.A. 103 (40): 14808–12. doi:10.1073/pnas.0604227103. PMID 17003125.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barcaroli D, Dinsdale D, Neale MH; et al. (2006). "FLASH is an essential component of Cajal bodies". Proc. Natl. Acad. Sci. U.S.A. 103 (40): 14802–7. doi:10.1073/pnas.0604225103. PMID 17003126.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Milovic-Holm K, Krieghoff E, Jensen K; et al. (2007). "FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies". EMBO J. 26 (2): 391–401. doi:10.1038/sj.emboj.7601504. PMID 17245429.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jeong EG, Lee SH, Lee HW; et al. (2007). "Immunohistochemical and mutational analysis of FLASH in gastric carcinomas". APMIS. 115 (8): 900–5. doi:10.1111/j.1600-0463.2007.apm_706.x. PMID 17696945.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)