CASP8AP2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''CASP8-associated protein 2''' is a [[protein]] that in humans is encoded by the ''CASP8AP2'' [[gene]].<ref name="pmid10235259">{{cite journal | vauthors = Imai Y, Kimura T, Murakami A, Yajima N, Sakamaki K, Yonehara S | title = The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis | journal = Nature | volume = 398 | issue = 6730 | pages = 777–85  | date = Jun 1999 | pmid = 10235259 | pmc =  | doi = 10.1038/19709 }}</ref><ref name="pmid17245429">{{cite journal | vauthors = Milovic-Holm K, Krieghoff E, Jensen K, Will H, Hofmann TG | title = FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies | journal = EMBO J. | volume = 26 | issue = 2 | pages = 391–401  | date = Jan 2007 | pmid = 17245429 | pmc = 1783462 | doi = 10.1038/sj.emboj.7601504 }}</ref><ref name="pmid17003126">{{cite journal | vauthors = Barcaroli D, Dinsdale D, Neale MH, Bongiorno-Borbone L, Ranalli M, Munarriz E, Sayan AE, McWilliam JM, Smith TM, Fava E, Knight RA, Melino G, De Laurenzi V | title = FLASH is an essential component of Cajal bodies | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 40 | pages = 14802–7  | date = Oct 2006 | pmid = 17003126 | pmc = 1578500 | doi = 10.1073/pnas.0604225103 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CASP8AP2 CASP8 associated protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9994| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CASP8 associated protein 2
| HGNCid = 1510
| Symbol = CASP8AP2
| AltSymbols =; CED-4; FLASH; FLJ11208; KIAA1315; RIP25
| OMIM = 606880
| ECnumber = 
| Homologene = 8066
| MGIid = 1349399
| Function = {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0005123 |text = death receptor binding}} {{GNF_GO|id=GO:0008656 |text = caspase activator activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006919 |text = caspase activation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008625 |text = induction of apoptosis via death domain receptors}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9994
    | Hs_Ensembl = ENSG00000118412
    | Hs_RefseqProtein = NP_036247
    | Hs_RefseqmRNA = NM_012115
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 90613030
    | Hs_GenLoc_end = 90637843
    | Hs_Uniprot = Q9UKL3
    | Mm_EntrezGene = 26885
    | Mm_Ensembl = ENSMUSG00000028282
    | Mm_RefseqmRNA = NM_011997
    | Mm_RefseqProtein = NP_036127
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 32944126
    | Mm_GenLoc_end = 32981873
    | Mm_Uniprot = Q3TNP9
  }}
}}
'''CASP8 associated protein 2''', also known as '''CASP8AP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CASP8AP2 CASP8 associated protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9994| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis.<ref name="entrez">{{cite web | title = Entrez Gene: CASP8AP2 CASP8 associated protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9994| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
CASP8AP2 has been shown to [[Protein-protein interaction|interact]] with [[TRAF2]].<ref name=pmid11340079>{{cite journal | vauthors = Choi YH, Kim KB, Kim HH, Hong GS, Kwon YK, Chung CW, Park YM, Shen ZJ, Kim BJ, Lee SY, Jung YK | title = FLASH coordinates NF-kappa B activity via TRAF2 | journal = J. Biol. Chem. | volume = 276 | issue = 27 | pages = 25073–7  | date = Jul 2001 | pmid = 11340079 | doi = 10.1074/jbc.M102941200 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Res. | volume = 9 | issue = 3 | pages = 99–106 | year = 2002 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 }}
| citations =
* {{cite journal | vauthors = Koonin EV, Aravind L, Hofmann K, Tschopp J, Dixit VM | title = Apoptosis. Searching for FLASH domains | journal = Nature | volume = 401 | issue = 6754 | pages = 662; discussion 662–3 | year = 1999 | pmid = 10537104 | doi = 10.1038/44317 }}
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
* {{cite journal | vauthors = Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 7 | issue = 1 | pages = 65–73 | year = 2000 | pmid = 10718198 | doi = 10.1093/dnares/7.1.65 }}
*{{cite journal  | author=Imai Y, Kimura T, Murakami A, ''et al.'' |title=The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis. |journal=Nature |volume=398 |issue= 6730 |pages= 777-85 |year= 1999 |pmid= 10235259 |doi= 10.1038/19709 }}
* {{cite journal | vauthors = Choi YH, Kim KB, Kim HH, Hong GS, Kwon YK, Chung CW, Park YM, Shen ZJ, Kim BJ, Lee SY, Jung YK | title = FLASH coordinates NF-kappa B activity via TRAF2 | journal = J. Biol. Chem. | volume = 276 | issue = 27 | pages = 25073–7 | year = 2001 | pmid = 11340079 | doi = 10.1074/jbc.M102941200 }}
*{{cite journal | author=Koonin EV, Aravind L, Hofmann K, ''et al.'' |title=Apoptosis. Searching for FLASH domains. |journal=Nature |volume=401 |issue= 6754 |pages= 662; discussion 662-3 |year= 1999 |pmid= 10537104 |doi= 10.1038/44317 }}
* {{cite journal | vauthors = Kino T, Chrousos GP | title = Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators | journal = J. Biol. Chem. | volume = 278 | issue = 5 | pages = 3023–9 | year = 2003 | pmid = 12477726 | doi = 10.1074/jbc.M209234200 }}
*{{cite journal | author=Nagase T, Kikuno R, Ishikawa KI, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 1 |pages= 65-73 |year= 2000 |pmid= 10718198 |doi= }}
* {{cite journal | vauthors = Jun JI, Chung CW, Lee HJ, Pyo JO, Lee KN, Kim NS, Kim YS, Yoo HS, Lee TH, Kim E, Jung YK | title = Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway | journal = Oncogene | volume = 24 | issue = 4 | pages = 688–96 | year = 2005 | pmid = 15592525 | doi = 10.1038/sj.onc.1208186 }}
*{{cite journal | author=Choi YH, Kim KB, Kim HH, ''et al.'' |title=FLASH coordinates NF-kappa B activity via TRAF2. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 25073-7 |year= 2001 |pmid= 11340079 |doi= 10.1074/jbc.M102941200 }}
* {{cite journal | vauthors = Kino T, Ichijo T, Chrousos GP | title = FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors | journal = J. Steroid Biochem. Mol. Biol. | volume = 92 | issue = 5 | pages = 357–63 | year = 2004 | pmid = 15698540 | doi = 10.1016/j.jsbmb.2004.09.003 }}
*{{cite journal | author=Kino T, Chrousos GP |title=Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators. |journal=J. Biol. Chem. |volume=278 |issue= 5 |pages= 3023-9 |year= 2003 |pmid= 12477726 |doi= 10.1074/jbc.M209234200 }}
* {{cite journal | vauthors = Flotho C, Coustan-Smith E, Pei D, Iwamoto S, Song G, Cheng C, Pui CH, Downing JR, Campana D | title = Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2 | journal = Blood | volume = 108 | issue = 3 | pages = 1050–7 | year = 2006 | pmid = 16627760 | pmc = 1895863 | doi = 10.1182/blood-2006-01-0322 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Barcaroli D, Bongiorno-Borbone L, Terrinoni A, Hofmann TG, Rossi M, Knight RA, Matera AG, Melino G, De Laurenzi V | title = FLASH is required for histone transcription and S-phase progression | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 40 | pages = 14808–12 | year = 2006 | pmid = 17003125 | pmc = 1578501 | doi = 10.1073/pnas.0604227103 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Jeong EG, Lee SH, Lee HW, Soung YH, Yoo NJ, Lee SH | title = Immunohistochemical and mutational analysis of FLASH in gastric carcinomas | journal = APMIS | volume = 115 | issue = 8 | pages = 900–5 | year = 2007 | pmid = 17696945 | doi = 10.1111/j.1600-0463.2007.apm_706.x }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Jun JI, Chung CW, Lee HJ, ''et al.'' |title=Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway. |journal=Oncogene |volume=24 |issue= 4 |pages= 688-96 |year= 2005 |pmid= 15592525 |doi= 10.1038/sj.onc.1208186 }}
*{{cite journal | author=Kino T, Ichijo T, Chrousos GP |title=FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors. |journal=J. Steroid Biochem. Mol. Biol. |volume=92 |issue= 5 |pages= 357-63 |year= 2005 |pmid= 15698540 |doi= 10.1016/j.jsbmb.2004.09.003 }}
*{{cite journal | author=Flotho C, Coustan-Smith E, Pei D, ''et al.'' |title=Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2. |journal=Blood |volume=108 |issue= 3 |pages= 1050-7 |year= 2006 |pmid= 16627760 |doi= 10.1182/blood-2006-01-0322 }}
*{{cite journal | author=Barcaroli D, Bongiorno-Borbone L, Terrinoni A, ''et al.'' |title=FLASH is required for histone transcription and S-phase progression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 40 |pages= 14808-12 |year= 2006 |pmid= 17003125 |doi= 10.1073/pnas.0604227103 }}
*{{cite journal  | author=Barcaroli D, Dinsdale D, Neale MH, ''et al.'' |title=FLASH is an essential component of Cajal bodies. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 40 |pages= 14802-7 |year= 2006 |pmid= 17003126 |doi= 10.1073/pnas.0604225103 }}
*{{cite journal | author=Milovic-Holm K, Krieghoff E, Jensen K, ''et al.'' |title=FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies. |journal=EMBO J. |volume=26 |issue= 2 |pages= 391-401 |year= 2007 |pmid= 17245429 |doi= 10.1038/sj.emboj.7601504 }}
*{{cite journal  | author=Jeong EG, Lee SH, Lee HW, ''et al.'' |title=Immunohistochemical and mutational analysis of FLASH in gastric carcinomas. |journal=APMIS |volume=115 |issue= 8 |pages= 900-5 |year= 2007 |pmid= 17696945 |doi= 10.1111/j.1600-0463.2007.apm_706.x }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
 
* {{UCSC genome browser|CASP8AP2}}
* {{UCSC gene details|CASP8AP2}}
 
 
{{gene-6-stub}}

Latest revision as of 02:27, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CASP8-associated protein 2 is a protein that in humans is encoded by the CASP8AP2 gene.[1][2][3][4]

Function

This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis.[4]

Interactions

CASP8AP2 has been shown to interact with TRAF2.[5]

References

  1. Imai Y, Kimura T, Murakami A, Yajima N, Sakamaki K, Yonehara S (Jun 1999). "The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis". Nature. 398 (6730): 777–85. doi:10.1038/19709. PMID 10235259.
  2. Milovic-Holm K, Krieghoff E, Jensen K, Will H, Hofmann TG (Jan 2007). "FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies". EMBO J. 26 (2): 391–401. doi:10.1038/sj.emboj.7601504. PMC 1783462. PMID 17245429.
  3. Barcaroli D, Dinsdale D, Neale MH, Bongiorno-Borbone L, Ranalli M, Munarriz E, Sayan AE, McWilliam JM, Smith TM, Fava E, Knight RA, Melino G, De Laurenzi V (Oct 2006). "FLASH is an essential component of Cajal bodies". Proc. Natl. Acad. Sci. U.S.A. 103 (40): 14802–7. doi:10.1073/pnas.0604225103. PMC 1578500. PMID 17003126.
  4. 4.0 4.1 "Entrez Gene: CASP8AP2 CASP8 associated protein 2".
  5. Choi YH, Kim KB, Kim HH, Hong GS, Kwon YK, Chung CW, Park YM, Shen ZJ, Kim BJ, Lee SY, Jung YK (Jul 2001). "FLASH coordinates NF-kappa B activity via TRAF2". J. Biol. Chem. 276 (27): 25073–7. doi:10.1074/jbc.M102941200. PMID 11340079.

Further reading

External links