Bupivacaine
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]
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Overview
Bupivacaine is a local anesthetic that is FDA approved for the {{{indicationType}}} of administration of analgesic, local, administration of analgesic, regional, anesthesia - dental procedure, anesthesia for procedures on eye, local anesthesia, regional anesthesia. Common adverse reactions include cardiovascular: bradyarrhythmia, heart block, ventricular arrhythmia immunologic: bacterial meningitis, septic, immune hypersensitivity reaction (rare ), musculoskeletal: chondrolysis of articular cartilage, neurologic: central nervous system depression, central nervous system stimulation, cranial nerve disorder, paraplegia, seizure (0.1% ), total spinal nerve blockade following local anesthetic injection, respiratory: respiratory arrest.
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
There is limited information regarding Bupivacaine FDA-Labeled Indications and Dosage (Adult) in the drug label.
Off-Label Use and Dosage (Adult)
Guideline-Supported Use
There is limited information about Off-Label Guideline-Supported Use of Bupivacaine in adult patients.
Non–Guideline-Supported Use
There is limited information about Off-Label Non–Guideline-Supported Use of Bupivacaine in adult patients.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
There is limited information regarding Bupivacaine FDA-Labeled Indications and Dosage (Pediatric) in the drug label.
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
There is limited information about Off-Label Guideline-Supported Use of Bupivacaine in pediatric patients.
Non–Guideline-Supported Use
There is limited information about Off-Label Non–Guideline-Supported Use of Bupivacaine in pediatric patients.
Contraindications
There is limited information regarding Bupivacaine Contraindications in the drug label.
Warnings
There is limited information regarding Bupivacaine Warnings' in the drug label.
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Bupivacaine Clinical Trials Experience in the drug label.
Postmarketing Experience
There is limited information regarding Bupivacaine Postmarketing Experience in the drug label.
Drug Interactions
There is limited information regarding Bupivacaine Drug Interactions in the drug label.
Use in Specific Populations
Pregnancy
Pregnancy Category (FDA):
There is no FDA guidance on usage of Bupivacaine in women who are pregnant.
Pregnancy Category (AUS):
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Bupivacaine in women who are pregnant.
Labor and Delivery
There is no FDA guidance on use of Bupivacaine during labor and delivery.
Nursing Mothers
There is no FDA guidance on the use of Bupivacaine in women who are nursing.
Pediatric Use
There is no FDA guidance on the use of Bupivacaine in pediatric settings.
Geriatic Use
There is no FDA guidance on the use of Bupivacaine in geriatric settings.
Gender
There is no FDA guidance on the use of Bupivacaine with respect to specific gender populations.
Race
There is no FDA guidance on the use of Bupivacaine with respect to specific racial populations.
Renal Impairment
There is no FDA guidance on the use of Bupivacaine in patients with renal impairment.
Hepatic Impairment
There is no FDA guidance on the use of Bupivacaine in patients with hepatic impairment.
Females of Reproductive Potential and Males
There is no FDA guidance on the use of Bupivacaine in women of reproductive potentials and males.
Immunocompromised Patients
There is no FDA guidance one the use of Bupivacaine in patients who are immunocompromised.
Administration and Monitoring
Administration
There is limited information regarding Bupivacaine Administration in the drug label.
Monitoring
There is limited information regarding Bupivacaine Monitoring in the drug label.
IV Compatibility
There is limited information regarding the compatibility of Bupivacaine and IV administrations.
Overdosage
There is limited information regarding Bupivacaine overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.
Pharmacology
There is limited information regarding Bupivacaine Pharmacology in the drug label.
Mechanism of Action
There is limited information regarding Bupivacaine Mechanism of Action in the drug label.
Structure
There is limited information regarding Bupivacaine Structure in the drug label.
Pharmacodynamics
There is limited information regarding Bupivacaine Pharmacodynamics in the drug label.
Pharmacokinetics
There is limited information regarding Bupivacaine Pharmacokinetics in the drug label.
Nonclinical Toxicology
There is limited information regarding Bupivacaine Nonclinical Toxicology in the drug label.
Clinical Studies
There is limited information regarding Bupivacaine Clinical Studies in the drug label.
How Supplied
There is limited information regarding Bupivacaine How Supplied in the drug label.
Storage
There is limited information regarding Bupivacaine Storage in the drug label.
Images
Drug Images
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Package and Label Display Panel
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Patient Counseling Information
There is limited information regarding Bupivacaine Patient Counseling Information in the drug label.
Precautions with Alcohol
Alcohol-Bupivacaine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
Brand Names
There is limited information regarding Bupivacaine Brand Names in the drug label.
Look-Alike Drug Names
There is limited information regarding Bupivacaine Look-Alike Drug Names in the drug label.
Drug Shortage Status
Price
References
The contents of this FDA label are provided by the National Library of Medicine.