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__NOTOC__
__NOTOC__
{{CMG}}
{{CMG}}; {{AE}} {{FH}}
{{Brain abscess}}
{{Brain abscess}}


==Overview==
==Overview==
Sterotactic aspiration of the brain abscess should be performed with the intention of identification of the causative pathogen and decompression in the absence of contraindications.  An abscess measures at least 2.5 cm in diameter has been recommended as an indication for intervention; however, with contemporary neurosurgical techniques, almost any brain abscess greater than 1 cm in diameter is amenable to aspiration regardless of location.<ref>{{Cite journal| doi = 10.1056/NEJMra1301635| issn = 1533-4406| volume = 371| issue = 5| pages = 447–456| last1 = Brouwer| first1 = Matthijs C.| last2 = Tunkel| first2 = Allan R.| last3 = McKhann| first3 = Guy M.| last4 = van de Beek| first4 = Diederik| title = Brain abscess| journal = The New England Journal of Medicine| date = 2014-07-31| pmid = 25075836}}</ref><ref>{{Cite journal| issn = 0148-396X| volume = 36| issue = 1| pages = 76–85; discussion 85-86| last1 = Mamelak| first1 = A. N.| last2 = Mampalam| first2 = T. J.| last3 = Obana| first3 = W. G.| last4 = Rosenblum| first4 = M. L.| title = Improved management of multiple brain abscesses: a combined surgical and medical approach| journal = Neurosurgery| date = 1995-01| pmid = 7708172}}</ref>
Surgery is the mainstay of treatment for patients with brain abscesses if the size of the abscess exceed 2.5 cm in diameter. The decision to drain the tumor surgically vs. [[aspiration]] is based on the number of abscesses, their size, and their location in the brain. Sterotactic aspiration of the brain abscess is performed for identifying causative [[pathogens]] and decompressions in the absence of contraindications.<ref name="pmid25075836">{{cite journal| author=Brouwer MC, Tunkel AR, McKhann GM, van de Beek D| title=Brain abscess. | journal=N Engl J Med | year= 2014 | volume= 371 | issue= 5 | pages= 447-56 | pmid=25075836 | doi=10.1056/NEJMra1301635 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25075836 }} </ref><ref name="bbb">{{Cite journal| issn = 0148-396X| volume = 36| issue = 1| pages = 76–85; discussion 85-86| last1 = Mamelak| first1 = A. N.| last2 = Mampalam| first2 = T. J.| last3 = Obana| first3 = W. G.| last4 = Rosenblum| first4 = M. L.| title = Improved management of multiple brain abscesses: a combined surgical and medical approach| journal = Neurosurgery| date = 1995-01| pmid = 7708172}}</ref>


==Surgery==
==Surgery==
The decision to drain the tumor surgically vs. aspiration is based on the number of abscesses, their size, and their location in the brain.
The decision to drain the tumor surgically vs. aspiration is based on:<ref name="pmid25075836">{{cite journal| author=Brouwer MC, Tunkel AR, McKhann GM, van de Beek D| title=Brain abscess. | journal=N Engl J Med | year= 2014 | volume= 371 | issue= 5 | pages= 447-56 | pmid=25075836 | doi=10.1056/NEJMra1301635 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25075836  }} </ref><ref name="bbb">{Cite journal| issn = 0148-396X| volume = 36| issue = 1| pages = 76–85; discussion 85-86| last1 = Mamelak| first1 = A. N.| last2 = Mampalam| first2 = T. J.| last3 = Obana| first3 = W. G.| last4 = Rosenblum| first4 = M. L.| title = Improved management of multiple brain abscesses: a combined surgical and medical approach| journal = Neurosurgery| date = 1995-01| pmid = 7708172}}</ref>
====Size of Abscess===
====Size of Abscess====
*''Smaller than 2.5 cm in diameter'': Administer antimicrobial therapy only.
*Smaller than 2.5 cm in diameter: Administer antimicrobial therapy only.
*''Larger than 2.5 cm in diameter'': Drain (either surgically or by repeated aspirations) and administer antimicrobial therapy.
*Larger than 2.5 cm in diameter: Drain (either surgically or by repeated aspirations) and administer antimicrobial therapy.
====Number of Abscesses====
====Number of Abscesses====
*''Single brain abscess'': A single brain abscess <2.5 cm in diameter are usually aspirated for culture and are not surgically drained.
*Single brain abscess: A single brain abscess less than 2.5 cm in diameter are usually aspirated for culture and are not surgically drained.
*''Multiple brain abscesses'': Repeated aspirations of multiple brain abscesses is preferred over surgical drainage.
*Multiple brain abscesses: Repeated aspirations of multiple brain abscesses is preferred over surgical drainage.
===Location of Abscess===
==== Location of Abscesses====
*Regions of sensory or motor cortex: Aspiration is preferred over surgical drainage.
*Regions of sensory or motor cortex: Aspiration is preferred over surgical drainage.
*Speech region: Aspiration is preferred over surgical drainage.
*Speech region: Aspiration is preferred over surgical drainage.
*Other regions: Either aspiration or surgical drainage.
*Other regions: Either aspiration or surgical drainage.


 
With contemporary neurosurgical techniques, almost any brain abscess greater than 1 cm in diameter is amenable to aspiration regardless of location. Regardless of the approach to drain the abscess, administration of long-term antimicrobial therapy is always recommended among all patients who are suspected to have brain abscess. To view the list antimicrobial regimens, click [[Brain abscess medical therapy|'''here''']].


==References==
==References==
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[[Category:Disease]]
[[Category:Disease]]
[[Category:Up-To-Date]]
[[Category:Neurology]]
[[Category:Neurology]]
[[Category:Neurosurgery]]
[[Category:Emergency medicine]]
[[Category:Infectious disease]]
[[Category:Infectious disease]]
[[Category:Neurosurgery]]

Latest revision as of 20:41, 29 July 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farwa Haideri [2]

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Overview

Surgery is the mainstay of treatment for patients with brain abscesses if the size of the abscess exceed 2.5 cm in diameter. The decision to drain the tumor surgically vs. aspiration is based on the number of abscesses, their size, and their location in the brain. Sterotactic aspiration of the brain abscess is performed for identifying causative pathogens and decompressions in the absence of contraindications.[1][2]

Surgery

The decision to drain the tumor surgically vs. aspiration is based on:[1][2]

Size of Abscess

  • Smaller than 2.5 cm in diameter: Administer antimicrobial therapy only.
  • Larger than 2.5 cm in diameter: Drain (either surgically or by repeated aspirations) and administer antimicrobial therapy.

Number of Abscesses

  • Single brain abscess: A single brain abscess less than 2.5 cm in diameter are usually aspirated for culture and are not surgically drained.
  • Multiple brain abscesses: Repeated aspirations of multiple brain abscesses is preferred over surgical drainage.

Location of Abscesses

  • Regions of sensory or motor cortex: Aspiration is preferred over surgical drainage.
  • Speech region: Aspiration is preferred over surgical drainage.
  • Other regions: Either aspiration or surgical drainage.

With contemporary neurosurgical techniques, almost any brain abscess greater than 1 cm in diameter is amenable to aspiration regardless of location. Regardless of the approach to drain the abscess, administration of long-term antimicrobial therapy is always recommended among all patients who are suspected to have brain abscess. To view the list antimicrobial regimens, click here.

References

  1. 1.0 1.1 Brouwer MC, Tunkel AR, McKhann GM, van de Beek D (2014). "Brain abscess". N Engl J Med. 371 (5): 447–56. doi:10.1056/NEJMra1301635. PMID 25075836.
  2. 2.0 2.1 Mamelak, A. N.; Mampalam, T. J.; Obana, W. G.; Rosenblum, M. L. (1995-01). "Improved management of multiple brain abscesses: a combined surgical and medical approach". Neurosurgery. 36 (1): 76–85, discussion 85-86. ISSN 0148-396X. PMID 7708172. Check date values in: |date= (help)