View source for Bradykinin receptor B2

{{DISPLAYTITLE:Bradykinin receptor B<sub>2</sub>}}
{{Infobox_gene}}
'''Bradykinin receptor B<sub>2</sub>''' is a [[G-protein coupled receptor]] for [[bradykinin]], encoded by the '''BDKRB2''' [[gene]] in humans.

==Mechanism==
The B<sub>2</sub> receptor is a [[G protein-coupled receptor]], probably coupled to [[Gq alpha subunit|G<sub>q</sub>]] and [[Gi alpha subunit|G<sub>i</sub>]]. G<sub>q</sub> stimulates [[phospholipase C]] to increase [[intracellular]] free [[calcium]] and G<sub>i</sub> inhibits [[adenylate cyclase]]. Furthermore, the receptor stimulates the [[mitogen-activated protein kinase]] pathways. It is ubiquitously and constitutively expressed in healthy tissues.

The B<sub>2</sub> receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS). The heptapeptide [[angiotensin (1-7)]] also potentiates bradykinin action on B<sub>2</sub> receptors.<ref name="pmid11230360">{{cite journal | vauthors = Fernandes L, Fortes ZB, Nigro D, Tostes RC, Santos RA, Catelli De Carvalho MH | title = Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo | journal = Hypertension | volume = 37 | issue = 2 Part 2 | pages = 703–9 | year = 2001 | pmid = 11230360 | doi = 10.1161/01.hyp.37.2.703| issn = | url = http://hyper.ahajournals.org/cgi/content/abstract/37/2/703 }}</ref>

[[Kallidin]] also signals through the B<sub>2</sub> receptor. An antagonist for the receptor is Hoe 140 ([[icatibant]]).<ref>{{Cite journal|title = Hoe 140 a new potent and long acting bradykinin-antagonist: in vivo studies | pmc=1917928 | pmid=1364852 | volume=102 | year=1991 | journal=Br. J. Pharmacol. | pages=774–7 | vauthors=Wirth K, Hock FJ, Albus U, Linz W, Alpermann HG, Anagnostopoulos H, Henk S, Breipohl G, König W, Knolle J | doi=10.1111/j.1476-5381.1991.tb12249.x}}</ref>

==Function==
The 9 [[amino acid]] bradykinin [[peptide]] elicits many responses including [[vasodilation]], [[edema]], [[smooth muscle spasm]] and [[pain fiber]] stimulation.

==Gene==
Alternate start codons result in two isoforms of the protein.<ref name="entrez">{{cite web | title = Entrez Gene: BDKRB2 bradykinin receptor B2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=624| accessdate = }}</ref>

==See also==
* [[Bradykinin receptor]]

==References==
{{reflist}}

==External links==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2976 | title = Bradykinin Receptors: B<sub>2</sub>  | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
* {{UCSC gene info|BDKRB2}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | vauthors=Duchêne J, Schanstra J, Cellier E |title=[30 years: Happy birthday, GPCR. The bradykinin B2 receptor: an alternative and antiproliferative pathway] |journal=Néphrologie |volume=23 |issue= 1 |pages= 39–41 |year= 2002 |pmid= 11908480 |doi=  |display-authors=etal}}
*{{cite journal  | vauthors=Ariza AC, Bobadilla NA, Halhali A |title=[Endothelin 1 and angiotensin II in preeeclampsia] |journal=Rev. Invest. Clin. |volume=59 |issue= 1 |pages= 48–56 |year= 2007 |pmid= 17569300 |doi=  }}
*{{cite journal  | vauthors=Hess JF, Borkowski JA, Young GS |title=Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor. |journal=Biochem. Biophys. Res. Commun. |volume=184 |issue= 1 |pages= 260–8 |year= 1992 |pmid= 1314587 |doi=10.1016/0006-291X(92)91187-U  |display-authors=etal}}
*{{cite journal  | vauthors=Eggerickx D, Raspe E, Bertrand D |title=Molecular cloning, functional expression and pharmacological characterization of a human bradykinin B2 receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=187 |issue= 3 |pages= 1306–13 |year= 1992 |pmid= 1329734 |doi=10.1016/0006-291X(92)90445-Q  |display-authors=etal}}
*{{cite journal  | vauthors=Kammerer S, Braun A, Arnold N, Roscher AA |title=The human bradykinin B2 receptor gene: full length cDNA, genomic organization and identification of the regulatory region. |journal=Biochem. Biophys. Res. Commun. |volume=211 |issue= 1 |pages= 226–33 |year= 1995 |pmid= 7779089 |doi= 10.1006/bbrc.1995.1800 }}
*{{cite journal  | vauthors=Braun A, Kammerer S, Böhme E |title=Identification of polymorphic sites of the human bradykinin B2 receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=211 |issue= 1 |pages= 234–40 |year= 1995 |pmid= 7779090 |doi= 10.1006/bbrc.1995.1801 |display-authors=etal}}
*{{cite journal  | vauthors=Ma JX, Wang DZ, Ward DC |title=Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor. |journal=Genomics |volume=23 |issue= 2 |pages= 362–9 |year= 1995 |pmid= 7835885 |doi= 10.1006/geno.1994.1512 |display-authors=etal}}
*{{cite journal  | vauthors=Powell SJ, Slynn G, Thomas C |title=Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14. |journal=Genomics |volume=15 |issue= 2 |pages= 435–8 |year= 1993 |pmid= 7916737 |doi= 10.1006/geno.1993.1084 |display-authors=etal}}
*{{cite journal  | vauthors=Menke JG, Borkowski JA, Bierilo KK |title=Expression cloning of a human B1 bradykinin receptor. |journal=J. Biol. Chem. |volume=269 |issue= 34 |pages= 21583–6 |year= 1994 |pmid= 8063797 |doi=  |display-authors=etal}}
*{{cite journal  | vauthors=Hess JF, Borkowski JA, Macneil T |title=Differential pharmacology of cloned human and mouse B2 bradykinin receptors. |journal=Mol. Pharmacol. |volume=45 |issue= 1 |pages= 1–8 |year= 1994 |pmid= 8302267 |doi=  |display-authors=etal}}
*{{cite journal  | vauthors=McIntyre P, Phillips E, Skidmore E |title=Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity. |journal=Mol. Pharmacol. |volume=44 |issue= 2 |pages= 346–55 |year= 1993 |pmid= 8394991 |doi=  |display-authors=etal}}
*{{cite journal  | vauthors=AbdAlla S, Godovac-Zimmermann J, Braun A |title=Structure of the bradykinin B2 receptors' amino terminus. |journal=Biochemistry |volume=35 |issue= 23 |pages= 7514–9 |year= 1996 |pmid= 8652530 |doi= 10.1021/bi9601060 |display-authors=etal}}
*{{cite journal  | vauthors=Isami S, Kishikawa H, Araki E |title=Bradykinin enhances GLUT4 translocation through the increase of insulin receptor tyrosine kinase in primary adipocytes: evidence that bradykinin stimulates the insulin signalling pathway. |journal=Diabetologia |volume=39 |issue= 4 |pages= 412–20 |year= 1996 |pmid= 8777990 |doi=10.1007/BF00400672  |display-authors=etal}}
*{{cite journal  | vauthors=Dalemar LR, Ivy Jong YJ, Wilhelm B, Baenziger NL |title=Protein kinases A and C rapidly modulate expression of human lung fibroblast B2 bradykinin receptor affinity forms. |journal=Eur. J. Cell Biol. |volume=69 |issue= 3 |pages= 236–44 |year= 1996 |pmid= 8900488 |doi=  }}
*{{cite journal  | vauthors=Soskic V, Nyakatura E, Roos M |title=Correlations in palmitoylation and multiple phosphorylation of rat bradykinin B2 receptor in Chinese hamster ovary cells. |journal=J. Biol. Chem. |volume=274 |issue= 13 |pages= 8539–45 |year= 1999 |pmid= 10085087 |doi=10.1074/jbc.274.13.8539  |display-authors=etal}}
*{{cite journal  | vauthors=Cassano G, Susca F, Lippe C, Guanti G |title=Two B1 and B2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin fibroblasts. |journal=Gen. Pharmacol. |volume=32 |issue= 2 |pages= 239–44 |year= 1999 |pmid= 10188626 |doi=10.1016/S0306-3623(98)00275-4  }}
*{{cite journal  | vauthors=Efremov R, Truong MJ, Darcissac EC |title=Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function. |journal=Eur. J. Biochem. |volume=263 |issue= 3 |pages= 746–56 |year= 1999 |pmid= 10469138 |doi=10.1046/j.1432-1327.1999.00553.x  |display-authors=etal}}
*{{cite journal  | vauthors=Marrero MB, Venema VJ, Ju H |title=Endothelial nitric oxide synthase interactions with G-protein-coupled receptors. |journal=Biochem. J. |volume=343 |issue=  2|pages= 335–40 |year= 1999 |pmid= 10510297 |doi=10.1042/0264-6021:3430335  | pmc=1220558  |display-authors=etal}}
*{{cite journal  | vauthors=Reyes-Cruz G, Vázquez-Prado J, Müller-Esterl W, Vaca L |title=Regulation of the human bradykinin B2 receptor expressed in sf21 insect cells: a possible role for tyrosine kinases |journal=J. Cell. Biochem. |volume=76 |issue= 4 |pages= 658–73 |year= 2000 |pmid= 10653985 |doi=10.1002/(SICI)1097-4644(20000315)76:4<658::AID-JCB14>3.0.CO;2-7  }}
*{{cite journal  | vauthors=Golser R, Gorren AC, Leber A |title=Interaction of endothelial and neuronal nitric-oxide synthases with the bradykinin B2 receptor. Binding of an inhibitory peptide to the oxygenase domain blocks uncoupled NADPH oxidation |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5291–6 |year= 2000 |pmid= 10681501 |doi=10.1074/jbc.275.8.5291  |display-authors=etal}}
}}
{{refend}}

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{{G protein-coupled receptors}}
{{Neuropeptide receptors}}
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[[Category:G protein-coupled receptors]]
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