Bowen's disease

Revision as of 14:17, 25 August 2014 by Jesus Hernandez (talk | contribs)
Jump to navigation Jump to search

Template:DiseaseDisorder infobox

WikiDoc Resources for Bowen's disease

Articles

Most recent articles on Bowen's disease

Most cited articles on Bowen's disease

Review articles on Bowen's disease

Articles on Bowen's disease in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Bowen's disease

Images of Bowen's disease

Photos of Bowen's disease

Podcasts & MP3s on Bowen's disease

Videos on Bowen's disease

Evidence Based Medicine

Cochrane Collaboration on Bowen's disease

Bandolier on Bowen's disease

TRIP on Bowen's disease

Clinical Trials

Ongoing Trials on Bowen's disease at Clinical Trials.gov

Trial results on Bowen's disease

Clinical Trials on Bowen's disease at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Bowen's disease

NICE Guidance on Bowen's disease

NHS PRODIGY Guidance

FDA on Bowen's disease

CDC on Bowen's disease

Books

Books on Bowen's disease

News

Bowen's disease in the news

Be alerted to news on Bowen's disease

News trends on Bowen's disease

Commentary

Blogs on Bowen's disease

Definitions

Definitions of Bowen's disease

Patient Resources / Community

Patient resources on Bowen's disease

Discussion groups on Bowen's disease

Patient Handouts on Bowen's disease

Directions to Hospitals Treating Bowen's disease

Risk calculators and risk factors for Bowen's disease

Healthcare Provider Resources

Symptoms of Bowen's disease

Causes & Risk Factors for Bowen's disease

Diagnostic studies for Bowen's disease

Treatment of Bowen's disease

Continuing Medical Education (CME)

CME Programs on Bowen's disease

International

Bowen's disease en Espanol

Bowen's disease en Francais

Business

Bowen's disease in the Marketplace

Patents on Bowen's disease

Experimental / Informatics

List of terms related to Bowen's disease

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Jesus Rosario Hernandez, M.D. [2].

Synonyms and keywords: Bowen's carcinoma; squamous cell carcinoma in situ of skin; intraepidermal carcinoma skin.

Overview

In medicine (dermatology), Bowen's disease (BD) is a sunlight-induced skin disease, considered either as an early stage or intraepidermal form of squamous cell carcinoma.

Historical Perspective

It was named after Dr John T. Bowen, the doctor who first described it in 1912.

Pathophysiology

Microscopic Pathology

The cells in Bowen's are extremely unusual or atypical under the microscope and in many cases look worse under the microscope than the cells of many outright and invading squamous cell carcinomas. The degree of atypia (strangeness, unusualness) seen under the microscope best tells how cells may behave should they invade another portion of the body.

Causes

Common Causes

Causes of BD include solar damage, arsenic, immunosuppression (including AIDS), viral infection (human papillomavirus or HPV) and chronic skin injury and dermatoses.

Causes in Alphabetical Order

Epidemiology and Demographics

Age

Bowen's disease may occur at any age in adults but is rare before the age of 30 years - most patients are aged over 60.

Gender

Bowen's disease occurs predominantly in women (70-85% of cases).

Diagnosis

Physical Examination

Bowen's disease typically presents as a gradually enlarging, well demarcated erythematous plaque with an irregular border and surface crusting or scaling.

Skin

Any site may be affected, although involvement of palms or soles is uncommon. A persistent progressive non-elevated red scaly or crusted plaque which is due to an intradermal carcinoma and is potentially malignant. Atypical squamous (resembling fish scales) cells proliferate through the whole thickness of the epidermis. The lesions may occur anywhere on the skin surface or on mucosal surfaces.

Extremities

About three-quarters of patients have lesions on the lower leg (60-85%), usually in previously or presently sun-exposed areas of skin.

Skinfolds

Genitourinary system=

Treatment

Surgery and Device Based Therapy

Photodynamic therapy (PDT), Cryotherapy (freezing) or local chemotherapy (with 5-fluorouracil) are favored by some clinicians over excision. Cauterization or diathermy coagulation are often effective treatments as well.

References


Template:WH Template:WS Template:Jb1