Biotin: Difference between revisions

Jump to navigation Jump to search
No edit summary
No edit summary
Line 16: Line 16:
<!--FDA-Labeled Indications and Dosage (Adult)-->
<!--FDA-Labeled Indications and Dosage (Adult)-->
|fdaLIADAdult=* Biotin is a major component of the formulation acts to strengthen the hair follicle and prevents hair loss as well. It is nutrient for the hair root and helps oxygenate the hair turn slowing the loss. Provides resilience and resistence to hair.  
|fdaLIADAdult=* Biotin is a major component of the formulation acts to strengthen the hair follicle and prevents hair loss as well. It is nutrient for the hair root and helps oxygenate the hair turn slowing the loss. Provides resilience and resistence to hair.  
*  Apply amount of the hair follicle and massage until absorbed continous product. Use every 12 hours for the fast and sustained effect.  
*  Apply amount of the hair follicle and massage until absorbed. Use every 12 hours for the fast and sustained effect.  
* Suitable for children, adolescents, adults and seniors.
* Suitable for children, adolescents, adults and seniors.
|offLabelAdultGuideSupport=* BIOTINIDASE DEFICIENCY, oral: 10 to 40 milligrams daily
|offLabelAdultGuideSupport=* BIOTINIDASE DEFICIENCY, oral: 10 to 40 milligrams daily
Line 39: Line 39:


<!--Guideline-Supported Use (Pediatric)-->
<!--Guideline-Supported Use (Pediatric)-->
|offLabelPedGuideSupport=* ALOPECIA AREATA, oral: 20 milligrams daily with oral zinc aspartate 100 milligrams and topical clobetasol propionate 0.025%
|offLabelPedGuideSupport=* [[ALOPECIA AREATA]], oral: 20 milligrams daily with oral zinc aspartate 100 milligrams and topical clobetasol propionate 0.025%
* BASAL-GANGLIA DISEASE, BIOTIN-responsive, oral or solution: 5 to 10 milligrams/kilogram daily
* BASAL-GANGLIA DISEASE, BIOTIN-responsive, oral or solution: 5 to 10 milligrams/kilogram daily
* BETA-METHYLCROTONYL-GLYCINURIA, solution, oral: 10 milligrams daily
* BETA-METHYLCROTONYL-GLYCINURIA, solution, oral: 10 milligrams daily

Revision as of 21:49, 16 December 2014

Biotin
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Disclaimer

WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.

Overview

Biotin is a vitamin that is FDA approved for the treatment of to strengthen the hair follicle and prevents hair loss as well. It is nutrient for the hair root and helps oxygenate the hair turn slowing the loss. Provides resilience and resistence to hair. Common adverse reactions include gastrointestinal upset, administration of anticonvulsant medications may impair Biotin absorption.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

  • Biotin is a major component of the formulation acts to strengthen the hair follicle and prevents hair loss as well. It is nutrient for the hair root and helps oxygenate the hair turn slowing the loss. Provides resilience and resistence to hair.
  • Apply amount of the hair follicle and massage until absorbed. Use every 12 hours for the fast and sustained effect.
  • Suitable for children, adolescents, adults and seniors.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

  • BIOTINIDASE DEFICIENCY, oral: 10 to 40 milligrams daily
  • BRITTLE NAILS, oral, tablet: 2.5 milligrams daily
  • CARBOXYLASE DEFICIENCY, intravenous, solution: 18.4 micromoles daily
  • HOLOCARBOXYLASE DEFICIENCY IN PREGNANCY, oral: 10 milligrams daily
  • PARENTERAL ALIMENTATION-INDUCED DEFICIENCY, oral, solution or tablet: 0.1 to 1 milligram daily
  • RECOMMENDED DIETARY ALLOWANCE (RDA), oral: 30 to 100 micrograms daily
  • VAGINAL CANDIDIASIS, oral: 20 milligrams daily

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Biotin in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Biotin in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

  • ALOPECIA AREATA, oral: 20 milligrams daily with oral zinc aspartate 100 milligrams and topical clobetasol propionate 0.025%
  • BASAL-GANGLIA DISEASE, BIOTIN-responsive, oral or solution: 5 to 10 milligrams/kilogram daily
  • BETA-METHYLCROTONYL-GLYCINURIA, solution, oral: 10 milligrams daily
  • BIOTINIDASE DEFICIENCY, solution or tablet, oral: 6 to 40 milligrams daily
  • PARENTERAL ALIMENTATION-INDUCED DEFICIENCY, solution or tablet, oral: 0.1 to 1 milligram daily
  • PARTIAL BIOTINIDASE DEFICIENCY, solution or tablet: 5 to 10 milligrams daily or less.
  • PROTEIN-ENERGY MALNUTRITION, solution or tablet, oral: BIOTIN 10 milligrams daily along with standard treatment for malnutrition
  • PYRUVATE-CARBOXYLASE DEFICIENCY, solution or tablet, oral: BIOTIN 10 milligrams (mg) daily, thiamine 80 mg daily, pyridoxine 300 mg daily
  • RECOMMENDED DIETARY ALLOWANCE, oral, diet or tablet: 50 micrograms daily
  • UNCOMBABLE HAIR SYNDROME, solution or tablet, oral: 0.9 milligram daily in three divided doses

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Biotin in pediatric patients.

Contraindications

  • Hypersensitivity to Biotin

Warnings

This product is for topical application, if this product to contact with eyes rinse immediately with water and consult your doctor.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Biotin in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

  • Gastrointestinal upset
  • Administration of anticonvulsant medications may impair Biotin absorption

Drug Interactions

There is limited information regarding Biotin Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Biotin in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Biotin during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Biotin with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Biotin with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Biotin with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Biotin with respect to specific gender populations.

Race

There is no FDA guidance on the use of Biotin with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Biotin in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Biotin in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Biotin in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Biotin in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral

Monitoring

There is limited information regarding Monitoring of Biotin in the drug label.

  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Biotin in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Biotin in the drug label.

Pharmacology

Template:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox E numberTemplate:Chembox AppearanceTemplate:Chembox MeltingPtTemplate:Chembox SolubilityInWaterTemplate:Chembox NFPATemplate:Chembox Supplement
Template:Chembox header2 | Biotin[1]
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
KEGG
UNII
Properties
C10H16N2O3S
Molar mass 244.31 g·mol−1
Hazards
Template:Chembox header2 | Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Mechanism of Action

There is limited information regarding Biotin Mechanism of Action in the drug label.

Structure

File:Biotin01.png
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Biotin in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Biotin in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Biotin in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Biotin in the drug label.

How Supplied

Storage

There is limited information regarding Biotin Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Biotin |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Biotin |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Biotin in the drug label.

Precautions with Alcohol

  • Alcohol-Biotin interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

  • BIONA-VIT ®[2]

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. Merck Index, 11th Edition, 1244.
  2. "BIONA-VIT CONTROLS AND PREVENTS HAIR LOSS- biotin liquid".
  3. "http://www.ismp.org". External link in |title= (help)

{{#subobject:

 |Label Page=Biotin
 |Label Name=Biotin 1.jpg

}}

{{#subobject:

 |Label Page=Biotin
 |Label Name=Biotin 2.png

}}

{{#subobject:

 |Label Page=Biotin
 |Label Name=Biotin 3.png

}}

{{#subobject:

 |Label Page=Biotin
 |Label Name=Biotin 4.png

}}

{{#subobject:

 |Label Page=Biotin
 |Label Name=

}}