Biliary dyskinesia overview: Difference between revisions
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== Differentiating Biliary dyskinesia from other Diseases == | == Differentiating Biliary dyskinesia from other Diseases == | ||
Biliary dyskinesia should be differentiated from other disorders that caused [[Right upper quadrant|right upper quadrant (RUQ)]] pain, such as [[Abdomen|abdominal]] disorders with pain similar to biliary pain, [[Peptic ulcer|peptic ulcer disease (PUD)]], [[Gastroesophageal reflux disease|gastroesophageal reflux disease (GERD)]], [[Irritable bowel syndrome|irritable bowel syndrome (IBS)]], coronary artery disease, costochondritis, and [[Musculoskeletal disorders|musculoskeletal disorder]]. <ref name="pmid30846030">{{cite journal| author=Clark CJ| title=An Update on Biliary Dyskinesia. | journal=Surg Clin North Am | year= 2019 | volume= 99 | issue= 2 | pages= 203-214 | pmid=30846030 | doi=10.1016/j.suc.2018.11.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30846030 }} </ref> | |||
== Epidemiology and Demographics == | == Epidemiology and Demographics == | ||
Revision as of 12:36, 15 August 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD[2]
Overview
Biliary dyskinesia is a failure of proper movement of the sphincter of Oddi.
Failure of the biliary sphincter can be distinguished from the pancreatic sphincter.
Overview
Pathophysiology
The exact pathophysiology of biliary dyskinesia is unknown.[1] However, there have been some suggestions as the causes of biliary dyskinesia such as the following: the biliary pain in gallbladder dyskinesia may be the result of gallbladder inflammation due ineffective gallbladder contraction caused by gallbladder dysmotility, visceral hypersensitivity, and receptor or neurologic abnormalities.[2] Consequently, abnormality in gallbladder or sphincter of Oddi contraction results in inflammation and biliary pain.[1]
Causes
The following motility disorders cause biliary colic without the presence of gallstones: functional gallbladder disorder (FGD) and sphincter of Oddi disorder (SOD).[3]
Differentiating Biliary dyskinesia from other Diseases
Biliary dyskinesia should be differentiated from other disorders that caused right upper quadrant (RUQ) pain, such as abdominal disorders with pain similar to biliary pain, peptic ulcer disease (PUD), gastroesophageal reflux disease (GERD), irritable bowel syndrome (IBS), coronary artery disease, costochondritis, and musculoskeletal disorder. [1]
Epidemiology and Demographics
The incidence of cholecystectomy procedure for biliary dyskinesia has been reported to be 85 cases per million individuals in the United States and about 25 cases per million individuals outside the United States.[4] The prevalence of functional gallbladder disorder (FGD) and sphincter of Oddi disorder (SOD) is unknown.[5]
Natural History and Prognosis
Symptoms of biliary dyskinesia have been reported to resolve without any invasive procedure in about half of the patients.[6] Patients with gallbladder dyskinesia (GD) that have typical classic biliary symptoms are more likely to have improvement after cholecystectomy compared to those with atypical symptoms.[7] Relief of symptoms has been reported in 80% of the patients that were diagnosed with sphincter of Oddi disorder (SOD) by manometry and treated with sphincterotomy.[8]
Diagnosis
History and Symptoms
In order to exclude other disorders, the patient's history is important in the diagnosis of biliary dyskinesia. Symptoms of biliary dyskinesia are characterized by biliary colic symptoms and include: postprandial pain in the right upper quadrant (RUQ) (that radiate to the flank, back, and right scapula), intolerance to fatty food, pain in the evening or awaking the patient at night, bloating, nausea and vomiting.[1]
Physical Examination
Symptoms of biliary dyskinesia are characterized by biliary colic symptoms. The following clinical presentations are not likely due to functional biliary disorder: positive Murphy’s sign, constant abdominal pain without tenderness, jaundice, and intermittent abdominal pain and cramps with episodes of diarrhea or constipation. [1]
Laboratory Findings
The initial laboratory work-up should include: liver function tests (AST, ALT, and total bilirubin), amylase, and lipase.[1]
CT
CT scan is not helpful in diagnosing gallbladder or biliary diseases.[1]
Ultrasound
Ultrasound is required in these patients in order to exclude structural conditions such as gallstone disease or cancer.[5] Ultrasound may be used in order to diagnose sphincter of oddi disorders (SOD) by measuring the common bile duct (CBD) diameter.[9]
Other Imaging Findings
Hepatobiliary iminodiacetic acid (HIDA) with an abnormal gallbladder ejection fraction (<40%) is a supportive criteria for diagnosing biliary dyskinesia but is not required for the diagnosis anymore.[1][10] Noninvasive procedures that may be used to evaluate and diagnose sphincter of Oddi disorders (SOD) are: ultrasound, HIDA scan, and MRCP.[9]
Other Diagnostic Studies
ERCP and sphincter of Oddi manometry may be used to rule out functional biliary sphincter of Oddi disorder (SOD) in patients who have had a cholecystectomy.[1] Although sphincter of Oddi manometry is the diagnostic tool for evaluating sphincter of Oddi disorders (SOD), it is an invasive procedure and has risk for complications.[5]
Treatment
Medical Therapy
Medical therapy mostly includes of symptomatic treatment of abdominal pain and IV opiates are the drug of choice, although some studies have suggested that opiates cause sphincter of Oddi contraction.[5][11]
Surgery
Laparoscopic cholecystectomy is used to treat biliary dyskinesia. Endoscopic biliary sphincterotomy is performed in patients with sphincter of Oddi disorder (SOD) diagnosed by manometry.[5]
Cost-Effectiveness of Therapy
There is insufficient evidence about the cost-effectiveness of therapy in biliary dyskinesia.
Future or Investigational Therapies
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Clark CJ (2019). "An Update on Biliary Dyskinesia". Surg Clin North Am. 99 (2): 203–214. doi:10.1016/j.suc.2018.11.004. PMID 30846030.
- ↑ Francis G, Baillie J (2011). "Gallbladder dyskinesia: fact or fiction?". Curr Gastroenterol Rep. 13 (2): 188–92. doi:10.1007/s11894-010-0172-6. PMID 21222059.
- ↑ Shaffer E (2003). "Acalculous biliary pain: new concepts for an old entity". Dig Liver Dis. 35 Suppl 3: S20–5. doi:10.1016/s1590-8658(03)00089-6. PMID 12974505.
- ↑ Preston JF, Diggs BS, Dolan JP, Gilbert EW, Schein M, Hunter JG (2015). "Biliary dyskinesia: a surgical disease rarely found outside the United States". Am J Surg. 209 (5): 799–803, discussion 803. doi:10.1016/j.amjsurg.2015.01.003. PMID 25771131.
- ↑ 5.0 5.1 5.2 5.3 5.4 Wilkins T, Agabin E, Varghese J, Talukder A (2017). "Gallbladder Dysfunction: Cholecystitis, Choledocholithiasis, Cholangitis, and Biliary Dyskinesia". Prim Care. 44 (4): 575–597. doi:10.1016/j.pop.2017.07.002. PMID 29132521.
- ↑ Bielefeldt K, Saligram S, Zickmund SL, Dudekula A, Olyaee M, Yadav D (2014). "Cholecystectomy for biliary dyskinesia: how did we get there?". Dig Dis Sci. 59 (12): 2850–63. doi:10.1007/s10620-014-3342-9. PMID 25193389.
- ↑ Carr JA, Walls J, Bryan LJ, Snider DL (2009). "The treatment of gallbladder dyskinesia based upon symptoms: results of a 2-year, prospective, nonrandomized, concurrent cohort study". Surg Laparosc Endosc Percutan Tech. 19 (3): 222–6. doi:10.1097/SLE.0b013e3181a74690. PMID 19542850.
- ↑ Toouli J (2002). "Biliary Dyskinesia". Curr Treat Options Gastroenterol. 5 (4): 285–291. doi:10.1007/s11938-002-0051-9. PMID 12095476.
- ↑ 9.0 9.1 Sgouros SN, Pereira SP (2006). "Systematic review: sphincter of Oddi dysfunction--non-invasive diagnostic methods and long-term outcome after endoscopic sphincterotomy". Aliment Pharmacol Ther. 24 (2): 237–46. doi:10.1111/j.1365-2036.2006.02971.x. PMID 16842450.
- ↑ Cotton PB, Elta GH, Carter CR, Pasricha PJ, Corazziari ES (2016). "Rome IV. Gallbladder and Sphincter of Oddi Disorders". Gastroenterology. doi:10.1053/j.gastro.2016.02.033. PMID 27144629.
- ↑ Behar J, Corazziari E, Guelrud M, Hogan W, Sherman S, Toouli J (2006). "Functional gallbladder and sphincter of oddi disorders". Gastroenterology. 130 (5): 1498–509. doi:10.1053/j.gastro.2005.11.063. PMID 16678563.