Bence Jones protein

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Overview

A Bence Jones protein is a monoclonal globulin protein found in the blood or urine. The isolated finding of a Bence Jones protein is known as monoclonal gammopathy of uncertain significance. Finding this protein in the context of end-organ manifestations such as renal failure, lytic bone disease, or anemia, or large numbers of plasma cells in the bone marrow of patients can be diagnostic of multiple myeloma.

The proteins are antibody immunoglobulin free light chains (paraproteins) and are produced by neoplastic plasma cells. The light chains can be detected by heating or electrophoresis of concentrated urine. Light chains precipitate when heated to 50 - 60 degrees C and redisolve at 90 -100 degrees C. These tests are essential in patients suspected of having Bence Jones proteins in their urine as these proteins don't react with the reagents normally utilized in urinalysis dipsticks. This leads to false negative results in people with Bence Jones proteins in their urine undergoing standard urinalysis. There are various rarer conditions which can produce Bence Jones proteins, such as Waldenström's macroglobulinemia and other malignanices.

The Bence Jones protein was described by the English physician Henry Bence Jones in 1847 and published in 1848.[1] The protein was later sequenced by Frank Putnam at the laboratory of Fred Sanger in Cambridge, who was the first to report the entire sequence.

References

  1. Jones HB. "On a new substance occurring in the urine of a patient with mollities ossium." Phil Trans R Soc Lond 1848;138:55-62.

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| group5 = Clinical Trials Involving Bence Jones protein | list5 = Ongoing Trials on Bence Jones protein at Clinical Trials.govTrial results on Bence Jones proteinClinical Trials on Bence Jones protein at Google


| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Bence Jones protein | list6 = US National Guidelines Clearinghouse on Bence Jones proteinNICE Guidance on Bence Jones proteinNHS PRODIGY GuidanceFDA on Bence Jones proteinCDC on Bence Jones protein


| group7 = Textbook Information on Bence Jones protein | list7 = Books and Textbook Information on Bence Jones protein


| group8 = Pharmacology Resources on Bence Jones protein | list8 = AND (Dose)}} Dosing of Bence Jones proteinAND (drug interactions)}} Drug interactions with Bence Jones proteinAND (side effects)}} Side effects of Bence Jones proteinAND (Allergy)}} Allergic reactions to Bence Jones proteinAND (overdose)}} Overdose information on Bence Jones proteinAND (carcinogenicity)}} Carcinogenicity information on Bence Jones proteinAND (pregnancy)}} Bence Jones protein in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Bence Jones protein


| group9 = Genetics, Pharmacogenomics, and Proteinomics of Bence Jones protein | list9 = AND (pharmacogenomics)}} Genetics of Bence Jones proteinAND (pharmacogenomics)}} Pharmacogenomics of Bence Jones proteinAND (proteomics)}} Proteomics of Bence Jones protein


| group10 = Newstories on Bence Jones protein | list10 = Bence Jones protein in the newsBe alerted to news on Bence Jones proteinNews trends on Bence Jones protein


| group11 = Commentary on Bence Jones protein | list11 = Blogs on Bence Jones protein

| group12 = Patient Resources on Bence Jones protein | list12 = Patient resources on Bence Jones proteinDiscussion groups on Bence Jones proteinPatient Handouts on Bence Jones proteinDirections to Hospitals Treating Bence Jones proteinRisk calculators and risk factors for Bence Jones protein


| group13 = Healthcare Provider Resources on Bence Jones protein | list13 = Symptoms of Bence Jones proteinCauses & Risk Factors for Bence Jones proteinDiagnostic studies for Bence Jones proteinTreatment of Bence Jones protein

| group14 = Continuing Medical Education (CME) Programs on Bence Jones protein | list14 = CME Programs on Bence Jones protein

| group15 = International Resources on Bence Jones protein | list15 = Bence Jones protein en EspanolBence Jones protein en Francais

| group16 = Business Resources on Bence Jones protein | list16 = Bence Jones protein in the MarketplacePatents on Bence Jones protein

| group17 = Informatics Resources on Bence Jones protein | list17 = List of terms related to Bence Jones protein


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