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{{Drugbox|
{{Drugbox
|IUPAC_name = (-)-N,α-Dimethylcyclohexaneethylammonium.5-ethyl-5-phenyl-barbiturate
| Verifiedfields = changed
| image=Barbexaclone.png
| verifiedrevid = 447439675
| CAS_number=4388-82-3
| image = Barbexaclon Structural Formula V1.svg
| ATC_prefix=N03
 
| ATC_suffix=AA04
<!--Combo data-->
| ATC_supplemental=
| type = combo
| PubChem=71196
| component1 = Phenobarbital
| DrugBank=
| class1 = [[Barbiturate]]
| C=22 | H=33 | N=3 | O=3
| component2 = Propylhexedrine
| molecular_weight = 387.52 g/mol
| class2 = [[Stimulant]] ([[Sympathomimetic drug|sympathomimetic]])
| bioavailability=  
 
| metabolism =  
<!--Clinical data-->
| elimination_half-life=
| tradename = 
| excretion =
| Drugs.com = {{drugs.com|international|barbexaclone}}
| pregnancy_category =
| pregnancy_category = 
| legal_status =
| legal_status = 
| routes_of_administration=  
| routes_of_administration = 
 
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 4388-82-3
| ATC_prefix = N03
| ATC_suffix = AA04
| PubChem = 71196
| DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank = DB09001
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 64332
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 291GX1YB65
 
<!--Chemical data-->
| smiles = O=C1NC(=O)NC(=O)C1(c2ccccc2)CC.N(C)[C@@H](C)CC1CCCCC1
| InChI = 1/C12H12N2O3.C10H21N/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16;1-9(11-2)8-10-6-4-3-5-7-10/h3-7H,2H2,1H3,(H2,13,14,15,16,17);9-11H,3-8H2,1-2H3/t;9-/m.0/s1
| InChIKey = MJCBWPMBFCUHBP-NPULLEENBB
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C12H12N2O3.C10H21N/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16;1-9(11-2)8-10-6-4-3-5-7-10/h3-7H,2H2,1H3,(H2,13,14,15,16,17);9-11H,3-8H2,1-2H3/t;9-/m.0/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = MJCBWPMBFCUHBP-NPULLEENSA-N
}}
}}
'''Barbexaclone''' (marketed in Italy as '''Maliasin''' by [[Abbott Laboratories]]) is a salt compound of [[phenobarbital]] and [[propylhexedrine]]. It was introduced in 1983. It is reported to be as effective as phenobarbital but better tolerated. 100&nbsp;mg of barbexaclone is equivalent to 60&nbsp;mg of phenobarbital. It is not available on prescription in the UK or U.S.


==References==
'''Barbexaclone''' ('''Maliasin''') is a salt compound of [[phenobarbital]] and [[levopropylhexedrine]]. It was introduced in 1983. It has been reported to be as effective as phenobarbital but better tolerated; however, as of 2004, these "promising results" had not yet been confirmed nor denied in controlled trials. 100 mg of barbexaclone is equivalent to 60 mg of phenobarbital.
 
== References ==
{{Reflist|2}}
* ''The Treatment of Epilepsy 2nd Ed'' by S. D. Shorvon (Editor), David R. Fish (Editor), Emilio Perucca (Editor), W. Edwin Dodson (Editor). Published by Blackwell 2004. [http://books.google.com/books?id=TfrwxdXcmosC&pg=PA472&dq=barbexaclone+intitle:epilepsy+inauthor:shorvon&hl=en&ei=gVvMTMGnC4uOjAeeyO3WBw&sa=X&oi=book_result&ct=result&resnum=1&ved=0CCkQ6AEwAA#v=onepage&q=barbexaclone%20intitle%3Aepilepsy%20inauthor%3Ashorvon&f=false p. 472]. ISBN 0-632-06046-8


* ''The Treatment of Epilepsy 2nd Ed'' by S. D. Shorvon (Editor), David R. Fish (Editor), Emilio Perucca (Editor), W. Edwin Dodson (Editor). Published by Blackwell 2004. ISBN 0-632-06046-8


{{Barbiturates}}
{{Anticonvulsants}}
{{Sedatives}}
{{Stimulants}}
{{Catecholaminergics}}
{{GABAAR PAMs}}


[[Category:Barbiturates]]
[[Category:Barbiturates]]
[[Category:Anticonvulsants]]
[[Category:Combination drugs]]
[[Category:GABAA receptor positive allosteric modulators]]
[[Category:Norepinephrine-dopamine releasing agents]]




{{pharma-stub}}
{{nervous-system-drug-stub}}
[[de:Barbexaclon]]
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Revision as of 14:03, 10 April 2015

Barbexaclone
File:Barbexaclon Structural Formula V1.svg
Combination of
PhenobarbitalBarbiturate
PropylhexedrineStimulant (sympathomimetic)
[[{{{component3}}}]]? Class
[[{{{component4}}}]]? Class
[[{{{component5}}}]]? Class
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

Barbexaclone (Maliasin) is a salt compound of phenobarbital and levopropylhexedrine. It was introduced in 1983. It has been reported to be as effective as phenobarbital but better tolerated; however, as of 2004, these "promising results" had not yet been confirmed nor denied in controlled trials. 100 mg of barbexaclone is equivalent to 60 mg of phenobarbital.

References

  • The Treatment of Epilepsy 2nd Ed by S. D. Shorvon (Editor), David R. Fish (Editor), Emilio Perucca (Editor), W. Edwin Dodson (Editor). Published by Blackwell 2004. p. 472. ISBN 0-632-06046-8


Template:Anticonvulsants Template:Sedatives Template:Stimulants Template:Catecholaminergics Template:GABAAR PAMs


Template:Nervous-system-drug-stub

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