BRIP1

BRCA1 interacting protein C-terminal helicase 1
Identifiers
Symbols	BRIP1 ; BACH1; OF; FANCJ; FLJ90232; MGC126521; MGC126523
External IDs	Template:OMIM5 Template:MGI HomoloGene: 32766
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

BRCA1 interacting protein C-terminal helicase 1, also known as BRIP1, is a human gene.

The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations.

Further reading

• Kobayashi A, Yamagiwa H, Hoshino H; et al. (2000). "A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain". Mol. Cell. Biol. 20 (5): 1733–46. PMID 10669750.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cantor SB, Bell DW, Ganesan S; et al. (2001). "BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function". Cell. 105 (1): 149–60. PMID 11301010.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Menichini P, Linial M (2001). "SUVi and BACH1: a new subfamily of mammalian helicases?". Mutat. Res. 487 (1–2): 67–71. PMID 11595410.
• Joo WS, Jeffrey PD, Cantor SB; et al. (2002). "Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure". Genes Dev. 16 (5): 583–93. doi:10.1101/gad.959202. PMID 11877378.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Luo L, Lei H, Du Q; et al. (2002). "No mutations in the BACH1 gene in BRCA1 and BRCA2 negative breast-cancer families linked to 17q22". Int. J. Cancer. 98 (4): 638–9. PMID 11920628.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Karppinen SM, Vuosku J, Heikkinen K; et al. (2003). "No evidence of involvement of germline BACH1 mutations in Finnish breast and ovarian cancer families". Eur. J. Cancer. 39 (3): 366–71. PMID 12565990.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rutter JL, Smith AM, Dávila MR; et al. (2004). "Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals". Hum. Mutat. 22 (2): 121–8. doi:10.1002/humu.10238. PMID 12872252.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki H, Tashiro S, Sun J; et al. (2004). "Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene". J. Biol. Chem. 278 (49): 49246–53. doi:10.1074/jbc.M306764200. PMID 14504288.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu X, Chini CC, He M; et al. (2003). "The BRCT domain is a phospho-protein binding domain". Science. 302 (5645): 639–42. doi:10.1126/science.1088753. PMID 14576433.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10.1074/jbc.C300407200. PMID 14578343.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cantor S, Drapkin R, Zhang F; et al. (2004). "The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2357–62. PMID 14983014.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shiozaki EN, Gu L, Yan N, Shi Y (2004). "Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling". Mol. Cell. 14 (3): 405–12. PMID 15125843.CS1 maint: Multiple names: authors list (link)
• Clapperton JA, Manke IA, Lowery DM; et al. (2004). "Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer". Nat. Struct. Mol. Biol. 11 (6): 512–8. doi:10.1038/nsmb775. PMID 15133502.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wada O, Oishi H, Takada I; et al. (2004). "BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220". Oncogene. 23 (35): 6000–5. doi:10.1038/sj.onc.1207786. PMID 15208681.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Botuyan MV, Nominé Y, Yu X; et al. (2005). "Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains". Structure. 12 (7): 1137–46. doi:10.1016/j.str.2004.06.002. PMID 15242590.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gupta R, Sharma S, Sommers JA; et al. (2005). "Analysis of the DNA substrate specificity of the human BACH1 helicase associated with breast cancer". J. Biol. Chem. 280 (27): 25450–60. doi:10.1074/jbc.M501995200. PMID 15878853.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)