BML-190

BML-190
	File:BML-190.png
Identifiers
	IUPAC name 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-1-morpholin-4-ylethanone;
PubChem CID	2415;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C23H23ClN2O4
Molar mass	426.892
3D model (JSmol)	Interactive image;
	SMILES C4COCCN4C(=O)Cc(c(c1cc2)cc2OC)c(C)n1C(=O)c3ccc(Cl)cc3;

BML-190 (Indomethacin morpholinylamide) is a drug used in scientific research which acts as a selective CB₂ inverse agonist.^[1] BML-190 is structurally derived from the NSAID indomethacin but has a quite different biological activity.^[2] The activity produced by this compound is disputed, with some sources referring to it as a CB₂ agonist rather than an inverse agonist;^[3]^[4] this may reflect an error in classification, or alternatively it may produce different effects in different tissues, more research is required to resolve this dispute.

References

↑ New DC, Wong YH. BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates. FEBS Letters. 2003 Feb 11;53(1-3):157-60. PMID 12586356
↑ Klegeris A, Bissonnette CJ, McGeer PL. Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. British Journal of Pharmacology. 2003 Jun;139(4):775-86. PMID 12813001
↑ Melck D, De Petrocellis L, Orlando P, Bisogno T, Laezza C, Bifulco M, Di Marzo V. Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation. Endocrinology. 2000 Jan;141(1):118-26. PMID 10614630
↑ Scutt A, Williamson EM. Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors. Calcified Tissue International. 2007 Jan;80(1):50-9. PMID 17205329

Template:Pharma-stub

Template:WikiDoc Sources

[1] New DC, Wong YH. BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates. FEBS Letters. 2003 Feb 11;53(1-3):157-60. PMID 12586356

[2] Klegeris A, Bissonnette CJ, McGeer PL. Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. British Journal of Pharmacology. 2003 Jun;139(4):775-86. PMID 12813001

[3] Melck D, De Petrocellis L, Orlando P, Bisogno T, Laezza C, Bifulco M, Di Marzo V. Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation. Endocrinology. 2000 Jan;141(1):118-26. PMID 10614630

[4] Scutt A, Williamson EM. Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors. Calcified Tissue International. 2007 Jan;80(1):50-9. PMID 17205329

[1]

[2]

[3]

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Identifiers
File:BML-190.png
IUPAC name 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-1-morpholin-4-ylethanone
PubChem CID	2415
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₃H₂₃ClN₂O₄
Molar mass	426.892
3D model (JSmol)	Interactive image
SMILES C4COCCN4C(=O)Cc(c(c1cc2)cc2OC)c(C)n1C(=O)c3ccc(Cl)cc3

BML-190

References

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