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Latest revision as of 14:18, 11 March 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aparna Vuppala, M.B.B.S. [2]

Synonyms and keywords: BEACOPP; BEACOPP Regimen; BEACOPP regimen; Bleomycin-Etoposide-Adriamycin-Cyclophosphamide-Oncovin-Procarbazine-Prednisone Regimen; Bleomycin/Cyclophosphamide/Doxorubicin/Etoposide/Prednisone/Procarbazine/Vincristine

Overview

BEACOPP regimen refers to an a chemotherapy regimen consisting of bleomycin, etoposide, doxorubicin hydrochloride (Adriamycin), cyclophosphamide, vincristine (Oncovin), procarbazine and prednisone, used for the treatment of advanced-stage Hodgkin lymphoma.^[1]^[2]

Regimen

BBleomycin

EEtoposide

ADoxorubicin (Adriamycin)

CCyclophosphamide

OVincristine (Oncovin)

PProcarbazine

PPrednisone

Indications

Advanced-stage Hodgkin lymphoma ^[3]

References

↑ "NCI Thesaurus".
↑ "R-CHOP - National Cancer Institute".
↑ Cheson BD (2014). "Which Hodgkin's patients in the Unites States should be treated with BEACOPP?". Curr Hematol Malig Rep. 9 (3): 222–6. doi:10.1007/s11899-014-0213-6. PMID 24879421.

[1] "NCI Thesaurus".

[2] "R-CHOP - National Cancer Institute".

[pmid24879421-3] Cheson BD (2014). "Which Hodgkin's patients in the Unites States should be treated with BEACOPP?". Curr Hematol Malig Rep. 9 (3): 222–6. doi:10.1007/s11899-014-0213-6. PMID 24879421.

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
+__NOTOC__
 {{SI}}
+{{CMG}}; {{AE}} {{AV}}
+{{SK}} BEACOPP; BEACOPP Regimen; BEACOPP regimen; Bleomycin-Etoposide-Adriamycin-Cyclophosphamide-Oncovin-Procarbazine-Prednisone Regimen; Bleomycin/Cyclophosphamide/Doxorubicin/Etoposide/Prednisone/Procarbazine/Vincristine
 ==Overview==
-'''BEACOPP''' is a [[chemotherapy regimen]] for treatment of [[Hodgkin's lymphoma]] in Stages > II. Patients typically receive treatment in cycles of 21 days with no drugs given on days 16-21. There also exists a more intensive regimen with cycles of 14 days. Usually a therapy consists of eight, sometimes six cycles. In some countries BEACOPP still is experimental, in others (eg. [[Germany]] and [[Austria]]) it is a standard therapy. The reason that the United States physicians still use ABVD (or Stanford V) is that they think that BEACOPP induces more secondary neoplasias as leukemias, etc. However, this (after 10 years of experience) is not the case. BEACOPP delivers approximately 10-15% more cures in advanced Hodgkins disease (IIB+risk factors or stages III and IV). BEACOPP is more expensive as it requires G-CSF support. However, it is well worth it because of the higher cure rates.
+{{PAGENAME}} refers to an a chemotherapy regimen consisting of [[bleomycin]], [[etoposide]], [[doxorubicin|doxorubicin hydrochloride (Adriamycin)]], [[cyclophosphamide]], [[vincristine|vincristine (Oncovin)]], [[procarbazine]] and [[prednisone]], used for the treatment of [[Hodgkin's lymphoma|advanced-stage Hodgkin lymphoma]].<ref>{{Cite web | title = NCI Thesaurus | accessdate =  | url = http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C63452 }}</ref><ref>{{Cite web | title = R-CHOP - National Cancer Institute | accessdate =  | url = http://www.cancer.gov/cancertopics/druginfo/R-CHOP }}</ref>
+==Regimen==
+{{chemo|B|Bleomycin}}
-m² = body surface
+{{chemo|E|Etoposide}}
-i.v.=[[intravenous]]
+{{chemo|A|Doxorubicin (Adriamycin)}}
-BEACOPP basic:
+{{chemo|C|Cyclophosphamide}}
-{|
-|[[Cyclophosphamide|'''(C)'''yclophosphamide]] || 650 mg/m² || (i.v.) || day 1
-|-
-|[[Adriamycin|'''(A)'''driamycin]] || 25 mg/m² || i.v. || day 1
-|-
-|[[Etoposide|'''(E)'''toposide]] || 100 mg/m² || i.v. || day 1-3
-|-
-|[[Vincristine|Vincristin(='''(O)'''ncovin)]] || 1,4 mg/m² (max 2 mg) || i.v. || day 8
-|-
-|[[Bleomycin|'''(B)'''leomycin]] || 10 mg/m² || i.v. || day 8
-|-
-|[[procarbazine|'''(P)'''rocarbazine]] || 100 mg/m² || orally || day 1-7
-|-
-|[[Prednisone|'''(P)'''rednisone]] || 40 mg/m² || orally || day 1-14
-|}
+{{chemo|O|Vincristine (Oncovin)}}
-BEACOPP escalated:
+{{chemo|P|Procarbazine}}
-{|
-|Cyclophosphamide || 1250 mg/m² KO/day || i.v. || day 1
-|-
-|Adriamycin || 35 mg/m² || i.v. || day 1
-|-
-|Etoposide || 200 mg/m² || i.v. || day 1-3
-|-
-|Vincristine || 1,4 mg/m² (max 2 mg) || i.v. || day 8
-|-
-|Bleomycin || 10 mg/m² || i.v. || day 8
-|-
-|Procarbazine || 100 mg/m² || orally || day 1-7
-|-
-|Prednisone || 40 mg/m² || orally || day 1-14
-|}
+{{chemo|P|Prednisone}}
-==See also==
+==Indications==
-* [[Stanford V]]
+* [[Hodgkin lymphoma|Advanced-stage Hodgkin lymphoma]] <ref name="pmid24879421">{{cite journal| author=Cheson BD| title=Which Hodgkin's patients in the Unites States should be treated with BEACOPP? | journal=Curr Hematol Malig Rep | year= 2014 | volume= 9 | issue= 3 | pages= 222-6 | pmid=24879421 | doi=10.1007/s11899-014-0213-6 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24879421  }} </ref>
-* [[ABVD]]
+==References==
+{{Reflist|2}}
+[[Category:Chemotherapy regimens]]
-[[Category:Cancer treatments]]
-[[de:BEACOPP]]
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