Autism future or investigational therapies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Future or Investigational Therapies

Although many alternative therapies and interventions are available, few are supported by scientific studies. Lack of support for interventions: [1] Treatment approaches have little empirical support in quality-of-life contexts, and many programs focus on success measures that lack predictive validity and real-world relevance. Scientific evidence appears to matter less to service providers than program marketing, training availability, and parent requests.[2] Although most alternative treatments, such as melatonin, have only mild adverse effects,[3] a 2008 study found that autistic boys on casein-free diets have significantly thinner bones,[4] and botched chelation therapy killed a five-year-old autistic boy in 2005.[5]

Approximately twelve research studies are published each week on autism therapies. Three major barriers inhibit transfer of this information from the laboratory to the child:

  • Treatment providers do not routinely turn to treatments that have been validated scientifically.
  • A large minority of patients (actually parents of patients) resist therapies that have been scientifically validated.
  • Even scientifically validated therapies are not universally effective.[6]

References

  1. *Francis K (2005). "Autism interventions: a critical update" (PDF). Dev Med Child Neurol. 47 (7): 493–9. doi:10.1017/S0012162205000952. PMID 15991872.
  2. Stahmer AC, Collings NM, Palinkas LA (2005). "Early intervention practices for children with autism: descriptions from community providers". Focus Autism Other Dev Disabl. 20 (2): 66–79. PMC 1350798. PMID 16467905.
  3. Angley M, Semple S, Hewton C, Paterson F, McKinnon R (2007). "Children and autism—part 2—management with complementary medicines and dietary interventions" (PDF). Aust Fam Physician. 36 (10): 827–30. PMID 17925903.
  4. Hediger ML, England LJ, Molloy CA, Yu KF, Manning-Courtney P, Mills JL (2008). "Reduced bone cortical thickness in boys with autism or autism spectrum disorder". J Autism Dev Disord. 38 (5): 848–56. doi:10.1007/s10803-007-0453-6. PMID 17879151. Lay summaryNIH News (2008-01-29).
  5. Brown MJ, Willis T, Omalu B, Leiker R (2006). "Deaths resulting from hypocalcemia after administration of edetate disodium: 2003–2005". Pediatrics. 118 (2): e534–6. doi:10.1542/peds.2006-0858. PMID 16882789.
  6. Bodfish JW (2004). "Treating the core features of autism: are we there yet?". Ment Retard Dev Disabil Res Rev. 10 (4): 318–26. doi:10.1002/mrdd.20045. PMID 15666340.

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