Asplenia historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalpana Giri, MBBS[2]

Overview

Hippocrates made the first description of the gross anatomy of the spleen in 421 BC. In 1899, Chauffard described that increased splenic activity is linked to hemolysis, and in 1910, Sutherland and Brughard performed the first therapeutic splenectomy in a patient with hereditary spherocytosis. In 1919, Morris and Bullock provided initial experimental evidence of the protective role of the spleen against infections.

Historical Perspective

References

  1. 1.0 1.1 William BM, Corazza GR (2007). "Hyposplenism: a comprehensive review. Part I: basic concepts and causes". Hematology. 12 (1): 1–13. doi:10.1080/10245330600938422. PMID 17364987.
  2. 2.0 2.1 2.2 Di Sabatino A, Carsetti R, Corazza GR (2011). "Post-splenectomy and hyposplenic states". Lancet. 378 (9785): 86–97. doi:10.1016/S0140-6736(10)61493-6. PMID 21474172.
  3. Fachet J, Foris G (1975). "Enodotoxin-induced non-specific resistance to Trypanosoma equiperdum in neonatally thymectomized or splenectomized Wistar rats". Keio J Med. 24 (4): 347–53. doi:10.2302/kjm.24.347. PMID 1228266.
  4. Kirkineska L, Perifanis V, Vasiliadis T (2014). "Functional hyposplenism". Hippokratia. 18 (1): 7–11. PMC 4103047. PMID 25125944.