Aspergillosis laboratory findings
Aspergillosis laboratory findings On the Web
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PCR is the method of choice for the diagnosis of aspergillosis. A single negative PCR result is sufficient to rule out aspergillosis, whereas two positive test results are required to confirm the diagnosis. Laboratory findings consistent with the diagnosis of aspergillosis include positive aspergillus antibody test, positive galactomannan test, elevated concentration of IgE immunoglobulin, and positive culture from sputum or bronchoalveolar lavage.
Polymerase Chain Reaction
- PCR is the method of choice for the diagnosis of Aspergillosis.
- A single negative PCR result is sufficient to rule out a diagnosis of a probable invasive aspergillosis.
- While, two positive test results are required to confirm a diagnosis of aspergillosis.
Other Laboratory Findings
Complete Blood Count
- Positive galactomannan assay
- Positive beta-D-glucan assay
- Positive culture and staining from sputum or from bronchoalveolar lavage (BAL)
- Culture can be performed on a variety of sterile specimens. Aspergillus spp. typically appear as rapidly growing molds that are visible 1-3 days following incubation.
- Patients with invasive aspergillosis may have negative cultures.
- Aspergillosis. Wikipedia (2015) https://en.wikipedia.org/wiki/Aspergillosis#Diagnosis Accessed on February, 8 2016
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- Mengoli C, Cruciani M, Barnes RA, Loeffler J, Donnelly JP (2009). "Use of PCR for diagnosis of invasive aspergillosis: systematic review and meta-analysis". Lancet Infect Dis. 9 (2): 89–96. doi:10.1016/S1473-3099(09)70019-2. PMID 19179225.