Arrhythmogenic right ventricular dysplasia causes

Overview

Arrhythmogenic right ventricular cardiomyopathy is typically inherited as an autosomal dominant pattern with variable penetrance and incomplete expression. Approximately 40% to 50% of ARVC/D patients have a mutation in genes encoding a desmosome protein. The gene is on the chromosome 14q23-q24.There is an autosomal recessive trait variant associated with palmoplantar keratosis and wooly hair named Naxos disease.

Causes

Arrhythmogenic right ventricular cardiomyopathy is cause by genetic inheritance as:

• An autosomal dominant pattern with variable penetrance and incomplete expression.
• A mutation in genes encoding a desmosome protein ( 40% to 50% of ARVC/D patients)
• The gene is on the chromosome 14q23-q24
• There is an autosomal recessive trait variant associated with palmoplantar keratosis and wooly hair named Naxos disease